公开(公告)号：US07892522B2

公开(公告)日：2011-02-22

申请号：US09950985

申请日：2001-09-13

申请人： David Johnson ,  Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad ,  Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

发明人： David Johnson ,  Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad ,  Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

IPC分类号： A61B8/00 ,  A61K9/127 ,  A61B8/14

CPC分类号： A61K49/223

摘要： Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

摘要翻译： 超声造影剂包括生物相容性气体的微泡，例如 卤化物或全氟化碳，通过可调节的两亲性材料稳定，例如。 成膜脂质如磷脂，特别是带负电荷的磷脂如磷脂酰丝氨酸，可以在静脉内给药后在肝脏中产生延长的对比度产生停留时间。

公开(公告)号：US06428479B1

公开(公告)日：2002-08-06

申请号：US09597406

申请日：2000-06-19

申请人： Anne Kirsti Aksnes ,  Morten Eriksen ,  Else Kruger Hagen ,  Audun Tornes

发明人： Anne Kirsti Aksnes ,  Morten Eriksen ,  Else Kruger Hagen ,  Audun Tornes

IPC分类号： A61B800

CPC分类号： A61B8/06 ,  A61B8/12 ,  A61B8/481 ,  A61B8/543

摘要： Prostate abnormalities such as cancer may be detected by ultrasonic determination of the in-flow kinetics of contrast agent-containing blood in the prostate and/or by observation of disease-related asymmetries in the spoke-like vascular pattern of the prostate.

摘要翻译： 可以通过超声波测定前列腺中含有造影剂的血液的流动动力学和/或通过观察前列腺的轮状血管图案中的疾病相关不对称性来检测前列腺癌的异常。

公开(公告)号：US20070066893A1

公开(公告)日：2007-03-22

申请号：US10558597

申请日：2004-12-03

申请人： Morten Eriksen ,  Lars Hoff ,  Henrik Rasmussen ,  Audun Tornes ,  Jonny Ostensen

发明人： Morten Eriksen ,  Lars Hoff ,  Henrik Rasmussen ,  Audun Tornes ,  Jonny Ostensen

IPC分类号： A61B6/00

CPC分类号： A61B5/415 ,  A61B5/1075 ,  A61B5/418 ,  A61B8/481 ,  A61K49/225

摘要： The present invention relates to a method of processing ultrasound images from a subject preadministered with an ultrasound contrast agent wherein quantitative measures of the contrast enhancement pattern of said lymph nodes are generated. The lymphatic system is made of vessels or ducts that begin in tissues and are designed to carry lymph fluid to local lymph nodes where the fluid is filtered and processed and sent to the next lymph node down the line until the fluid reaches the thoracic duct where it enters the blood stream. Lymph fluid which enters the lymph vessels carries with it substances and materials from the tissue, e.g. antigens, particles and cells. The lymph nodes process the lymph fluid by sieving it and macrophages inside the nodes remove particulate and cell material carried by the lymph fluid via phagocytosis.

摘要翻译： 本发明涉及一种处理来自预先给予超声造影剂的受试者的超声图像的方法，其中产生所述淋巴结的对比度增强模式的定量测量。 淋巴系统由在组织中开始并被设计成将淋巴液携带到淋巴结的淋巴管构成，其中流体被过滤和处理，并被送到下一个淋巴结，直到流体到达胸廓管 进入血液流。 进入淋巴管的淋巴液携带来自组织的物质和物质，例如， 抗原，颗粒和细胞。 淋巴结通过筛选淋巴液和淋巴结内的巨噬细胞通过吞噬除去淋巴液携带的颗粒和细胞物质。

公开(公告)号：US20060173339A1

公开(公告)日：2006-08-03

申请号：US10530094

申请日：2003-10-01

申请人： Audun Tornes ,  Jonny Ostensen ,  Henrik Rasmussen

发明人： Audun Tornes ,  Jonny Ostensen ,  Henrik Rasmussen

IPC分类号： A61B8/14

CPC分类号： A61K49/223 ,  A61K9/0009 ,  A61K9/5015

摘要： The present invention relates methods for the identification of a sentinel lymph node and to compounds and preparations used in said methods.

摘要翻译： 本发明涉及用于鉴定前哨淋巴结的方法和用于所述方法的化合物和制剂。

公开(公告)号：US06689065B2

公开(公告)日：2004-02-10

申请号：US10162126

申请日：2002-06-04

申请人： Anne Kirsti Aksnes ,  Morten Eriksen ,  Else Kruger Hagen ,  Audun Tornes

发明人： Anne Kirsti Aksnes ,  Morten Eriksen ,  Else Kruger Hagen ,  Audun Tornes

IPC分类号： A61B806

CPC分类号： A61B8/06 ,  A61B8/12 ,  A61B8/481 ,  A61B8/543

摘要： Prostate abnormalities such as cancer may be detected by ultrasonic determination of the in-flow kinetics of contrast agent-containing blood in the prostate and/or by observation of disease-related asymmetries in the the spoke-like vascular pattern of the prostate.

摘要翻译： 可以通过超声波测定前列腺中含有造影剂的血液的流动动力学和/或通过观察前列腺的轮状血管图案中的疾病相关不对称来检测前列腺异常，例如癌症。

公开(公告)号：US07083566B2

公开(公告)日：2006-08-01

申请号：US10275373

申请日：2001-04-12

申请人： Audun Tornes ,  Morten Eriksen

发明人： Audun Tornes ,  Morten Eriksen

IPC分类号： A61N5/00

CPC分类号： A61N5/1027 ,  A61B2090/3925 ,  A61N2005/1024

摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of the outer surface of the container is grooved, preferably with a curved groove. The grooved outer surface is preferably substantially free from angularities. Such grooves enhance the echogenicity of the source using medical ultrasound at a greater range of angles to the ultrasound probe, thus enhancing the ultrasound visibility of the source. Preferred radioisotopes are palladium-103 and iodine-125.

公开(公告)号：US06595925B1

公开(公告)日：2003-07-22

申请号：US09503165

申请日：2000-02-14

申请人： Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad

发明人： Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad

IPC分类号： A61B814

CPC分类号： A61K49/223

摘要： Ultrasound imaging using gas microbubble-containing contrast agents may be performed in the recirculating phase following admixture of the contrast agent with the blood pool, thereby prolonging the useful imaging time window compared to that conventionally obtained during the backscatter signal peak resulting from first pass of a contrast agent bolus. The length of the time window may further be increased by imaging at ultrasound frequencies of 2 MHz or less, particularly by harmonic imaging at transmit frequencies less than the resonance frequencies of the gas microbubbles.

摘要翻译： 使用气体微泡造影剂的超声成像可以在造影剂与血液池混合之后的再循环阶段中进行，从而延长了有用的成像时间窗口，与之前获得的反向散射信号峰值相比， 造影剂推注。 特别是通过低于气体微泡的共振频率的发射频率下的谐波成像，可以进一步通过在2MHz或更小的超声频率下成像来增加时间窗口的长度。