公开(公告)号：US07892522B2

公开(公告)日：2011-02-22

申请号：US09950985

申请日：2001-09-13

申请人： David Johnson ,  Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad ,  Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

发明人： David Johnson ,  Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad ,  Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

IPC分类号： A61B8/00 ,  A61K9/127 ,  A61B8/14

CPC分类号： A61K49/223

摘要： Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

摘要翻译： 超声造影剂包括生物相容性气体的微泡，例如 卤化物或全氟化碳，通过可调节的两亲性材料稳定，例如。 成膜脂质如磷脂，特别是带负电荷的磷脂如磷脂酰丝氨酸，可以在静脉内给药后在肝脏中产生延长的对比度产生停留时间。

公开(公告)号：US06375931B2

公开(公告)日：2002-04-23

申请号：US09291277

申请日：1999-04-14

申请人： Jonny Østensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pål Rongved

发明人： Jonny Østensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pål Rongved

IPC分类号： A61B800

CPC分类号： A61K49/223 ,  Y10S977/928 ,  Y10S977/929

摘要： Ultrasonic visualization of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

摘要翻译： 使用新型含气体的造影剂制剂，使用受试者的超声波可视化，特别是心肌和其他组织中的灌注进行，其在给药后在体内促进气相的可控和临时生长，因此可用作沉积的灌注示踪剂。 制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。 在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

公开(公告)号：US06595925B1

公开(公告)日：2003-07-22

申请号：US09503165

申请日：2000-02-14

申请人： Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad

发明人： Jonny Østensen ,  Morten Eriksen ,  Audun Tornes ,  Sigmund Frigstad

IPC分类号： A61B814

CPC分类号： A61K49/223

摘要： Ultrasound imaging using gas microbubble-containing contrast agents may be performed in the recirculating phase following admixture of the contrast agent with the blood pool, thereby prolonging the useful imaging time window compared to that conventionally obtained during the backscatter signal peak resulting from first pass of a contrast agent bolus. The length of the time window may further be increased by imaging at ultrasound frequencies of 2 MHz or less, particularly by harmonic imaging at transmit frequencies less than the resonance frequencies of the gas microbubbles.

摘要翻译： 使用气体微泡造影剂的超声成像可以在造影剂与血液池混合之后的再循环阶段中进行，从而延长了有用的成像时间窗口，与之前获得的反向散射信号峰值相比， 造影剂推注。 特别是通过低于气体微泡的共振频率的发射频率下的谐波成像，可以进一步通过在2MHz或更小的超声频率下成像来增加时间窗口的长度。

公开(公告)号：US06783752B2

公开(公告)日：2004-08-31

申请号：US10007325

申请日：2001-12-05

申请人： Jonny Østensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pål Rongved

发明人： Jonny Østensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pål Rongved

IPC分类号： A61B800

CPC分类号： A61K49/223 ,  Y10S977/928 ,  Y10S977/929

摘要： Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

摘要翻译： 使用新型含气体的造影剂制剂进行超声波可视化，特别是心肌和其他组织中的灌注，其可在给药后在体内促进气相的可控和临时生长，因此可用作沉积灌注示踪剂。 制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。 在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

公开(公告)号：US06811766B1

公开(公告)日：2004-11-02

申请号：US09553048

申请日：2000-04-20

申请人： Morten Eriksen ,  Jonny Østensen ,  Sigmund Frigstad ,  Pål Rongved

发明人： Morten Eriksen ,  Jonny Østensen ,  Sigmund Frigstad ,  Pål Rongved

IPC分类号： A61B800

CPC分类号： A61K49/223

摘要： A combined preparation comprising: i) an ultrasound contrast agent capable of accumulation in tissue microvasculature; and ii) a pharamacologically effective amount of a vasodilator drug may be used in perfusion imaging, especially of the myocardium. The contrast agent accumulates in tissue in concentrations related to the regional rate of tissue perfusion, and the vasodilator drug enhances distinction between normally perfused and underperfused tissue.

摘要翻译： 一种组合制剂，其包含：i）能够积聚在组织微血管中的超声造影剂; 和ii）药理学有效量的血管扩张剂药物可以用于灌注成像，特别是心肌的成像。 造影剂以与组织灌注的区域速率相关的浓度积累在组织中，并且血管扩张剂药物增强了正常灌注和欠灌注组织之间的区别。

公开(公告)号：US06315730B1

公开(公告)日：2001-11-13

申请号：US09425290

申请日：1999-10-25

申请人： Lars Hoff ,  Jonny Østensen ,  Sigmund Frigstad ,  Morten Eriksen

发明人： Lars Hoff ,  Jonny Østensen ,  Sigmund Frigstad ,  Morten Eriksen

IPC分类号： A61B814

CPC分类号： A61B8/481 ,  A61B8/06 ,  A61B8/13 ,  A61K41/0028 ,  A61K49/223

摘要： A method of measuring tissue perfusion in a human or non-human animal subject which comprises administering an effective amount of an ultrasound contrast agent to said subject, irradiating tissue in a target region with at least one pulse of ultrasound having energy sufficient to destroy or discernibly modify the echogenic properties of substantially all contrast agent in said target region, and ultrasonically detecting and quantifying the rate of flow of either further contrast agent into said target region or modified contrast agent out of said target region.

摘要翻译： 一种测量人或非人类动物受试者中的组织灌注的方法，其包括向所述受试者施用有效量的超声造影剂，用至少一个具有足以破坏或可辨别的能量的超声波照射目标区域中的组织 修改所述目标区域中基本上所有造影剂的回声特性，并且超声检测和定量任何另外的造影剂进入所述目标区域或修改的造影剂在所述目标区域之外的流速。