公开(公告)号：US09029332B2

公开(公告)日：2015-05-12

申请号：US13994296

申请日：2011-12-15

Applicant: Qing Lin ,  Avinash Muppidi

Inventor： Qing Lin ,  Avinash Muppidi

IPC: A61K38/12 ,  C07K7/56 ,  C07K1/107 ,  C07K7/08 ,  C07K14/47

CPC classification number: C07K7/56 ,  C07K1/1077 ,  C07K7/08 ,  C07K14/4747 ,  C07K2319/00 ,  C07K2319/95

Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。

公开(公告)号：US20140057857A1

公开(公告)日：2014-02-27

申请号：US13994296

申请日：2011-12-15

Applicant: Qing Lin ,  Avinash Muppidi

Inventor： Qing Lin ,  Avinash Muppidi

IPC: C07K7/56

CPC classification number: C07K7/56 ,  C07K1/1077 ,  C07K7/08 ,  C07K14/4747 ,  C07K2319/00 ,  C07K2319/95

Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。