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1.发明授权公开(公告)号：US09029332B2
公开(公告)日：2015-05-12
申请号：US13994296
申请日：2011-12-15
Applicant: Qing Lin , Avinash Muppidi
Inventor： Qing Lin , Avinash Muppidi
CPC classification number: C07K7/56 , C07K1/1077 , C07K7/08 , C07K14/4747 , C07K2319/00 , C07K2319/95
Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.
Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。
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2.发明申请公开(公告)号：US20140057857A1
公开(公告)日：2014-02-27
申请号：US13994296
申请日：2011-12-15
Applicant: Qing Lin , Avinash Muppidi
Inventor： Qing Lin , Avinash Muppidi
IPC: C07K7/56
CPC classification number: C07K7/56 , C07K1/1077 , C07K7/08 , C07K14/4747 , C07K2319/00 , C07K2319/95
Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.
Abstract translation: 交联蛋白质和肽，以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可以用作药物递送制剂。 与亲本蛋白质或肽相比，交联的蛋白质和肽可以具有改善的性质，例如细胞通透性。
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公开(公告)号：US08685435B2
公开(公告)日：2014-04-01
申请号：US10837355
申请日：2004-04-30
Applicant: Thierry Nivaggioli , Jane Guo Shiah , Qing Lin
Inventor： Thierry Nivaggioli , Jane Guo Shiah , Qing Lin
IPC: A61F2/00
CPC classification number: A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
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4.发明授权Peptide-peptidase-inhibitor conjugates and methods of making and using same 失效肽 - 肽酶 - 抑制剂缀合物及其制备和使用方法公开(公告)号：US08598314B2
公开(公告)日：2013-12-03
申请号：US12680539
申请日：2008-09-26
Applicant: Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
Inventor： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
CPC classification number: A61K47/64 , A61K47/545 , A61K47/55
Abstract: Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
Abstract translation: 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US08586707B2
公开(公告)日：2013-11-19
申请号：US12561107
申请日：2009-09-16
Applicant: Qing Lin , Mike Madden
Inventor： Qing Lin , Mike Madden
CPC classification number: C07K1/045 , C07K1/107 , C07K1/1136
Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
Abstract translation: 一种制备缝合肽的方法。 根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。 螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。
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Patent Agency Ranking
公开(公告)号：US20130014289A1
公开(公告)日：2013-01-10
申请号：US13580935
申请日：2010-02-24
Applicant: Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
Inventor： Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
CPC classification number: C07K14/415 , C12N15/8271
Abstract: Compositions and methods for imparting stress tolerance to plants using WRKY nucleic acid and polypeptides.
Abstract translation: 使用WRKY核酸和多肽赋予植物胁迫耐受性的组合物和方法。
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公开(公告)号：US20080138339A1
公开(公告)日：2008-06-12
申请号：US11895207
申请日：2007-08-22
Applicant: Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
Inventor： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
CPC classification number: C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
Abstract translation: 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。
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公开(公告)号：US08759295B2
公开(公告)日：2014-06-24
申请号：US12785396
申请日：2010-05-21
Applicant: Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
Inventor： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC: A61K38/26 , C07K14/605 , C07K19/00 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12
CPC classification number: A61K47/48246 , A61K47/545 , A61K47/55 , A61K47/64
Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
Abstract translation: 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US08598120B2
公开(公告)日：2013-12-03
申请号：US13364250
申请日：2012-02-01
Applicant: Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David G. Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine M. Mack , Qing Lin
Inventor： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David G. Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine M. Mack , Qing Lin
IPC: A61K38/16 , A61P3/04 , A61P5/22 , C07K14/435 , C07K19/00
CPC classification number: C07K14/575
Abstract: The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
Abstract translation: 本发明涉及在胰岛淀粉样多肽家族中具有肽功能的新化合物，相关核酸，表达构建体，宿主细胞，并且处理化合物的生产。 本发明的化合物包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。
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10.发明申请Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS 有权聚乙二醇/聚（对苯二甲酸丁二醇酯）共聚物涂层装置，包括EVEROLIMUS公开(公告)号：US20130087270A1
公开(公告)日：2013-04-11
申请号：US10807546
申请日：2004-03-22
Applicant: Syed Faiyaz Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
Inventor： Syed Faiyaz Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
IPC: A61F2/82
CPC classification number: B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
Abstract translation: 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。
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