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公开(公告)号：US20180236386A1
公开(公告)日：2018-08-23
申请号：US15522960
申请日：2015-10-14
发明人： Rainer BAUER
CPC分类号： B01D46/002 , B01D46/0019 , B01D46/0065 , B01D46/0068 , B01D46/04 , B01D46/10 , B01D46/4272
摘要： A cleaning method for sectional cleaning of a filter is proposed, the filter having several filter sections, by means of one cleaning process one of the filter sections at a time being cleaned, the filter sections being cleaned within one cleaning cycle in cleaning processes separated in time from one another, the cleaning method having at least two cleaning cycles and both one time interval between the cleaning processes within the respective cleaning cycle and also one time interval between the end of one of the cleaning cycles and the start of a following one of the cleaning cycles being changed, and/or the filter having at least three filter sections, the filter sections being cleaned in cleaning processes separated by time intervals from one another and the time intervals between successive cleaning processes being changed. Moreover a connecting device for connecting a filter to a cleaning device is proposed, the connecting device having one side wall which borders an internal cross section which increases along one longitudinal axis of the connecting device and has openings laterally with assigned major axes.
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公开(公告)号：US20170340645A1
公开(公告)日：2017-11-30
申请号：US15678286
申请日：2017-08-16
IPC分类号： A61K31/538 , A61K31/46 , A61K9/12 , A61K31/40 , A61K9/00 , A61K45/06 , A61K31/439
CPC分类号： A61K31/538 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/124 , A61K31/40 , A61K31/439 , A61K31/46 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprising:(a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.
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公开(公告)号：US20040261792A1
公开(公告)日：2004-12-30
申请号：US10747341
申请日：2003-12-29
IPC分类号： A61M015/00
CPC分类号： A61M15/00 , A61B5/087 , A61M2202/064 , A61M2205/3331 , A61M2209/02
摘要： The invention relates to a control unit for flow regulation for use in an apparatus for testing the delivery of a dose of powder from a powder inhaler, a collecting tube for use in conjunction with the control unit and an apparatus containing the control unit and the collecting tube.
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公开(公告)号：US20040242613A1
公开(公告)日：2004-12-02
申请号：US10766079
申请日：2004-01-27
发明人： Mario G. Cardozo , Derek Cogan , Charles Lawrence Cywin , Georg Dahmann , Darren DiSalvo , John David Ginn , Anthony S. Prokopowicz III , Denice M. Spero , Erick Young
IPC分类号： A61K031/506 , A61K031/505
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04 , H01L51/0089
摘要： Disclosed are novel compounds of formula (I): 1 wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 公开了式（I）的新化合物：其中R 1，R 2和R 3如本文所定义，其可用作PKC-θ的抑制剂，因此可用于治疗通过该活性介导或维持的多种疾病和病症 的PKC-θ，包括免疫学障碍和II型糖尿病。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20040235861A1
公开(公告)日：2004-11-25
申请号：US10882613
申请日：2004-07-01
发明人： Franco Borsini
IPC分类号： A61K031/496
CPC分类号： A61K31/496 , A61K31/495 , A61K45/06
摘要： The present invention relates to the use of 1-null2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl)ethylnull-2,3-dihydro-1H-benzimidazol-2-one, optionally in the form of its pharmaceutically acceptable acid addition salts and optionally in the form of its hydrates or solvates, for preparing a pharmaceutical composition with a neuroprotective activity.
摘要翻译： 本发明涉及1- [2-（4-（3-三氟甲基 - 苯基）哌嗪-1-基）乙基] -2,3-二氢-1H-苯并咪唑-2-酮的用途， 的药学上可接受的酸加成盐，并且任选地以其水合物或溶剂化物的形式，用于制备具有神经保护活性的药物组合物。
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6.发明申请Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions 有权羧酸酰胺，其制备及其作为药物组合物的用途公开(公告)号：US20040220169A1
公开(公告)日：2004-11-04
申请号：US10741727
申请日：2003-12-19
发明人： James Gillard , Sandra Ruth Handschuh , Herbert Nar , Roland Pfau , Henning Priepke , Wolfgang Wienen , Annette Mario Schuler-Metz , Eckhart Bauer , Georg Dahmann , Kai Gerlach
IPC分类号： A61K031/397 , A61K031/55 , A61K031/445 , A61K031/40
CPC分类号： C07D231/12 , C07D209/14 , C07D215/12 , C07D215/18 , C07D233/56 , C07D235/14 , C07D235/16 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/10 , C07D495/04 , C07D513/04
摘要： The present invention relates to new substituted carboxylic acid amides of general formula 1 wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
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![3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition](/abs-image/US/2004/09/09/US20040176392A1/abs.jpg.150x150.jpg)
7.发明申请3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition 有权3-Z- [1-（4-（N（（4-甲基 - 哌嗪-1-基） - 甲基羰基）-N-甲基 - 氨基） - 苯胺基）-1-苯基 - 亚甲基] -6-甲氧基羰基 - 2-二氢吲哚酮 - 单乙磺酸盐及其作为药物组合物的用途公开(公告)号：US20040176392A1
公开(公告)日：2004-09-09
申请号：US10623971
申请日：2003-07-21
发明人： Gerald J. Roth , Guenter Linz , Peter Sieger , Werner Rall , Frank Hilberg , Thomas Bock
IPC分类号： A61K031/497 , C07D43/02
CPC分类号： C07D209/34
摘要： The present invention relates to the compound 3-Z-null1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylenenull-6-methoxycarbonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition. 1
摘要翻译： 本发明涉及化合物3-Z- [1-（4-（N - （（4-甲基 - 哌嗪-1-基） - 甲基羰基）-N-甲基 - 氨基） - 苯胺基）-1-苯基 - 亚甲基] -6-甲氧基羰基-2-二氢吲哚酮 - 单乙磺酸盐及其作为药物组合物的用途。
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8.发明申请Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds 有权具有MCH拮抗活性的酰胺化合物和包含这些化合物的药物公开(公告)号：US20040152742A1
公开(公告)日：2004-08-05
申请号：US10699089
申请日：2003-10-31
发明人： Dirk Stenkamp , Stephan Georg Mueller , Gerald Juergen Roth , Philipp Lustenberger , Klaus Rudolf , Thorsten Lehmann-Lintz , Kirsten Arndt , Ralf Lotz , Martin Lenter , Heike-Andrea Wieland
IPC分类号： A61K031/54 , A61K031/535 , A61K031/497 , A61K031/44
CPC分类号： C07D213/30 , C07C233/29 , C07C235/24 , C07C237/04 , C07C255/60 , C07C275/32 , C07C2601/14 , C07D207/09 , C07D207/20 , C07D209/08 , C07D211/46 , C07D211/62 , C07D213/56 , C07D295/03 , C07D295/088 , C07D295/13 , C07D307/42 , C07D333/16
摘要： The present invention relates to amide compounds of general formula I 1 wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one amide according to the invention. In view of the MCH receptor-antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
摘要翻译： 本发明涉及通式I的酰胺化合物，其中基团和残基A，B，b，W，X，Y，Z，R 1，R 2和R 3具有权利要求书中给出的含义 此外，本发明涉及含有根据本发明的至少一种酰胺的药物组合物。 鉴于MCH受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖，贪食症，厌食症，食欲过盛和糖尿病。
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公开(公告)号：US20040133032A1
公开(公告)日：2004-07-08
申请号：US10727225
申请日：2003-12-03
IPC分类号： C07C069/76 , C07C069/66
CPC分类号： C07D309/32 , C07C67/56 , C07C69/738
摘要： The invention relates to a process for preparing optically active 5-hydroxy-3-ketoesters of formula A1 or A2, 1 or one of the tautomers thereof, the use thereof for preparing optically active dihydropyrones of formula B, 2 and the use of the dihydropyrones of formula B thus prepared as starting compounds for preparing pharmaceutically active compounds, particularly Tipranavir.
摘要翻译： 本发明涉及一种制备式A1或A2的光学活性5-羟基-3-酮酯或其互变异构体之一的方法，其用于制备式B的光学活性二氢吡喃酮的用途，以及式 B制备为制备药物活性化合物，特别是替拉他韦的起始化合物。
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公开(公告)号：US20040132760A1
公开(公告)日：2004-07-08
申请号：US10718403
申请日：2003-11-20
IPC分类号： C07D451/02 , C07D491/08 , A61K031/4745 , A61K031/46
CPC分类号： C07D451/06
摘要： A compound of formula 1 1 wherein Xnull, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in pharmaceutical compositions, and methods of treating patients using them.
摘要翻译： 式1的化合物，其中X 1，A，R 1，R 2，R 3和R 4可以具有权利要求书和说明书中给出的含义，其制备方法 ，它们在药物组合物中的用途，以及使用它们治疗患者的方法。
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