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公开(公告)号：US20240270729A1
公开(公告)日：2024-08-15
申请号：US18569370
申请日：2022-06-15
发明人： Pierre Ducray , Denise Rageot , Andreas Turberg
IPC分类号： C07D413/04 , A61K31/4439 , A61P33/14 , C07D413/14
CPC分类号： C07D413/04 , A61K31/4439 , A61P33/14 , C07D413/14
摘要： The present invention provides compounds of formula (I):
which are useful for long-lasting treatment and control of pests, optionally fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.-
公开(公告)号：US20240131151A1
公开(公告)日：2024-04-25
申请号：US17970170
申请日：2022-10-19
CPC分类号： A61K39/39 , A61K47/544 , A61K47/6911 , A61P37/04 , A61K2039/6018
摘要： The present application relates to an immunostimulatory composition including a liposome-nucleic acid complex wherein said complex contains (1) a liposome which, interms of its lipids, includes or consists of a first lipid and a second lipid, wherein the first lipid is a zwitterionic lipid and the second lipid is a cationic lipid, and (2) one or more immunostimulatory oligonucleotides and/or one or more polynucleotides. The application further relates to certain uses of the immunostimulatory composition and to methods for preparing the same. In particular, the application concerns the use of a zwitterionic lipid in an immunostimulatory composition including a liposome-nucleic acid complex to induce type I interferon immune responses and/or to reduce or even bypass TLR-mediated immune responses.
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公开(公告)号：US11932857B2
公开(公告)日：2024-03-19
申请号：US16772541
申请日：2018-12-07
发明人： Thomas Ilg
IPC分类号： C12N15/117 , A61K39/00 , A61K39/39 , A61P37/04
CPC分类号： C12N15/117 , A61K39/39 , A61P37/04 , A61K2039/55555 , A61K2039/55561 , A61K2039/60 , C12N2310/17 , C12N2310/315 , C12N2310/3341 , C12N2310/3515 , C12N2320/31
摘要： Compositions and methods for stimulating toll-like receptor 9 (TLR9) are provided. More particularly, immunostimulatory oligonucleotides, methods of enhancing immunostimulatory properties of oligonucleotides, and methods of eliciting immune responses are disclosed herein.
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公开(公告)号：US20230046680A1
公开(公告)日：2023-02-16
申请号：US17603548
申请日：2020-04-08
发明人： Andreas TURBERG , Iring HEISLER , Joachim TELSER , Alexander ARLT , Peter JESCHKE , Hans-Georg SCHWARZ , Martin FUESSLEIN , Yolanda CANCHO GRANDE , Kerstin ILG , Ulrich EBBINGHAUS-KINTSCHER , Peter LOESEL , Marc LINKA , Arunas Jonas DAMIJONAITIS , Ingo LIMBERG
IPC分类号： C07D413/14 , C07D417/14 , A01N43/78 , A01N43/76 , A01N43/653 , A01N43/90 , C07D471/04 , C07D403/14
摘要： The present invention relates to novel heteroaryl-substituted aminoalkyl azole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3 and R4 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
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公开(公告)号：US20220274971A1
公开(公告)日：2022-09-01
申请号：US17630742
申请日：2020-07-27
发明人： Bernd ALIG , Walter HUEBSCH , Nils GRIEBENOW , Hans-Georg SCHWARZ , Wei ZHUANG , Daniel KULKE , Claudia BOEHM , Iring HEISLER , Isa Jana Irina JANSSEN , Kirsten BOERNGEN
IPC分类号： C07D413/14 , C07D405/12
摘要： The present invention covers new isoquinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11382865B2
公开(公告)日：2022-07-12
申请号：US16467922
申请日：2017-11-30
IPC分类号： A61K9/24 , A61K9/20 , A61K31/27 , A61K31/35 , A61K31/4985 , A61K31/506
摘要： The present invention refers to a pharmaceutical preparation (10) comprising a first pharmaceutical composition having a matrix material and pharmaceutically active ingredients distributed within the matrix material, wherein the first pharmaceutical composition comprises Praziquantel, Pyrantel and Febantel as pharmaceutical active ingredients, wherein the preparation (10) comprises a second pharmaceutical composition having a matrix material and at least one of avermectins and milbemycins such as Moxidectin as pharmaceutically active ingredient distributed within the matrix material, wherein the preparation (10) is provided in a multi-layer structure such, that the first composition is provided in a first layer (12) and the second composition is provided in a second layer (14), wherein the first layer (12) and the second layer (14) are separated by a barrier layer (16) being provided between the first layer (12) and the second layer (14).
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公开(公告)号：US11357755B2
公开(公告)日：2022-06-14
申请号：US17256867
申请日：2019-06-27
发明人： Joachim Telser , Ursula Krenz , Kirsten Boerngen , Andreas Turberg , Klein Sofia , Franziska Schmidt
IPC分类号： C07C69/96 , C07D231/12 , A61K31/4155 , A61P33/14 , A61K9/00 , A61K31/415
摘要： The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.
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8.发明申请公开(公告)号：US20210228612A1
公开(公告)日：2021-07-29
申请号：US15734847
申请日：2019-05-29
发明人： Stefan Hofmann , Kirsten Borngen , Maya Vinzing
IPC分类号： A61K31/715 , A61K31/53 , A61K33/26 , A61K47/10 , A61K47/12 , A61K47/44 , A61K47/32 , A61K47/26 , A61K9/00
摘要： The present invention relates to a formulation for use in the simultaneous treatment of coccidial infections and iron deficiencies containing a triazinone such as toltrazuril and a polynuclear iron(III) polysaccharide complex compound together with a specifically selected surfactant that has a hydrophilic-lipophilic-balance (HLB) value of ≥10.
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公开(公告)号：US10851379B2
公开(公告)日：2020-12-01
申请号：US15962414
申请日：2018-04-25
发明人： Marc Munnes , Christian Weiss , Elisabeth Feldhues , Romina G. Schauer , Albert Abraham , Andrea Eicker , Hermann Wehlmann
IPC分类号： C07H21/04 , A61K31/70 , C12N15/117 , A61K47/54 , A61K39/108 , A61K39/245 , A61K45/06 , A61K9/127 , A01K67/00 , A61K39/00
摘要： The present invention relates to immunomodulator compositions and methods of use as well as methods of making. The immunomodulator compositions comprise immunostimulatory plasmids, or DNA sequence, capable of eliciting an immune response in a recipient subject. Further, the immunostimulatory plasmids, or DNA sequence, do not contain antibiotic resistance coding sequence to help reduce the potential of horizontal transfer of antibiotic resistance in a population.
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公开(公告)号：US10751361B2
公开(公告)日：2020-08-25
申请号：US16058888
申请日：2018-08-08
发明人： Albert Abraham , Daniel Keil , Jason Nickell , Christian Weiss
IPC分类号： A61K39/00 , A61K39/38 , A61K31/711 , A61K9/127 , A61K39/102 , A61K9/00 , A61K39/39 , A61K45/06
摘要： The present invention relates to a method of immune activation which is effective for eliciting a non-antigen-specific immune response in a member of the bovine species. The method is particularly effective for protecting a member of the bovine species from infectious disease and treating animals inflicted with infectious disease.
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