公开(公告)号：US20240270729A1

公开(公告)日：2024-08-15

申请号：US18569370

申请日：2022-06-15

申请人： ELANCO TIERGESUNDHEIT AG ,  BAYER ANIMAL HEALTH GMBH

发明人： Pierre Ducray ,  Denise Rageot ,  Andreas Turberg

IPC分类号： C07D413/04 ,  A61K31/4439 ,  A61P33/14 ,  C07D413/14

CPC分类号： C07D413/04 ,  A61K31/4439 ,  A61P33/14 ,  C07D413/14

摘要： The present invention provides compounds of formula (I):




which are useful for long-lasting treatment and control of pests, optionally fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

公开(公告)号：US11938103B2

公开(公告)日：2024-03-26

申请号：US17281914

申请日：2019-09-30

申请人： Elanco Tiergesundheit AG

发明人： Sarah George ,  Peter Rolfe ,  Chouaib Tahtaoui

IPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

CPC分类号： A61K31/167 ,  A61K31/63 ,  A61P33/10

摘要： The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.

公开(公告)号：US11612471B2

公开(公告)日：2023-03-28

申请号：US17634898

申请日：2020-08-14

申请人： Elanco Tiergesundheit AG ,  ELANCO US INC.

发明人： Jianbin Li ,  Benjamin Jeffrey Cooper

IPC分类号： A61D7/00

摘要： An arrangement for delivery of a substance to an animal and a method of protection of a winged capsule. The arrangement may include a winged capsule including a capsule and wings, the capsule being adapted to deliver the substance to the animal, and the wings affixed to the capsule and operable to fold for insertion into the animal and to expand after insertion. The arrangement may include a wing protector including a slot sized and configured to receive at least a portion of each of the wings and removably attach the winged capsule to the wing protector. The method may include removably attaching the winged capsule to the wing protector to form a protected winged capsule; inserting a plurality of the protected winged capsule into a bag; removing one of the protected winged capsule from the bag; and removing the wing protector from the protected winged capsule.

公开(公告)号：US20220265412A1

公开(公告)日：2022-08-25

申请号：US17634898

申请日：2020-08-14

申请人： Elanco Tiergesundheit AG ,  ELANCO US INC.

发明人： Jianbin LI ,  Benjamin Jeffrey COOPER

IPC分类号： A61D7/00

摘要： An arrangement for delivery of a substance to an animal and a method of protection of a winged capsule. The arrangement may include a winged capsule including a capsule and wings, the capsule being adapted to deliver the substance to the animal, and the wings affixed to the capsule and operable to fold for insertion into the animal and to expand after insertion. The arrangement may include a wing protector including a slot sized and configured to receive at least a portion of each of the wings and removably attach the winged capsule to the wing protector. The method may include removably attaching the winged capsule to the wing protector to form a protected winged capsule; inserting a plurality of the protected winged capsule into a bag; removing one of the protected winged capsule from the bag; and removing the wing protector from the protected winged capsule.

公开(公告)号：US20190380981A1

公开(公告)日：2019-12-19

申请号：US16557341

申请日：2019-08-30

申请人： Elanco Tiergesundheit AG

发明人： David Blaser ,  Jacques Bouvier ,  Martin Fink ,  John Gerard McHenery ,  Steve Nanchen

IPC分类号： A61K31/17 ,  A61K9/50

摘要： The present invention concerns the use of lufenuron for controlling sea lice in a fish population, which comprises feeding lufenuron to the fish population according to a specific regime as outlined in the specification and claims. The process is especially suited for the treatment of salmon and provides prolonged effective protection against sea lice at sea.

公开(公告)号：US10464889B2

公开(公告)日：2019-11-05

申请号：US16037396

申请日：2018-07-17

申请人： ELANCO Tiergesundheit AG

发明人： Noelle Gauvry ,  Chouaib Tahtaoui

IPC分类号： C07C311/08 ,  C07D277/62 ,  C07D213/61 ,  C07D213/84 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07C307/10 ,  C07D333/24 ,  C07D333/28 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/29 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D249/12 ,  C07D277/30 ,  C07D277/64 ,  C07D279/12 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D213/26 ,  C07D213/64 ,  C07D213/65 ,  C07C311/09 ,  C07C235/56 ,  C07F5/02 ,  C07F7/08 ,  C07D209/08 ,  C07D213/56 ,  C07D215/06 ,  C07D237/26 ,  C07D249/08 ,  C07D263/50 ,  C07D275/03 ,  C07D277/46 ,  C07D277/54 ,  C07D277/56 ,  C07D277/60 ,  C07D285/135 ,  C07D309/06 ,  C07D317/66 ,  C07D333/78 ,  C07D487/04

摘要： The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

公开(公告)号：US10370375B2

公开(公告)日：2019-08-06

申请号：US16055560

申请日：2018-08-06

申请人： Elanco Tiergesundheit AG

发明人： Noelle Gauvry ,  Chouaib Tahtaoui ,  Pascal Furet ,  Pierre Ducray

IPC分类号： C07D471/14 ,  C07D239/46 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D239/42 ,  C07D239/48

摘要： The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.

公开(公告)号：US10261092B2

公开(公告)日：2019-04-16

申请号：US14696904

申请日：2015-04-27

申请人： Elanco Tiergesundheit AG

发明人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

IPC分类号： G01N33/50 ,  G01N33/68 ,  A61K39/102 ,  A61K39/00

摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.

公开(公告)号：US09790280B2

公开(公告)日：2017-10-17

申请号：US14354280

申请日：2012-10-25

申请人： Elanco Tiergesundheit AG

发明人： Sarah Rue ,  Brendan Eckelman ,  Quinn Deveraux ,  Marc Nasoff

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  G01N33/574 ,  A61K45/06

CPC分类号： C07K16/2887 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/57426

摘要： This disclosure relates to immunogens and monoclonal antibodies useful in the identification and/or treatment of cancer cells, including those of the dog. In one example, chimeric anti-canine CD20 antibodies are provided. The antibodies can be used therapeutically to treat lymphoma in dogs.

公开(公告)号：US20240360116A1

公开(公告)日：2024-10-31

申请号：US18255134

申请日：2021-12-03

申请人： ELANCO TIERGESUNDHEIT AG

发明人： Francois PAUTRAT ,  Chouaib TAHTAOUI ,  Pierre DUCRAY ,  Denise RAGEOT

IPC分类号： C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

CPC分类号： C07D413/14 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/541 ,  A61K31/69 ,  A61P33/10 ,  C07D265/36 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07F5/02

摘要： The present invention provides compounds of formula (I′):




which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.