公开(公告)号：US5591428A

公开(公告)日：1997-01-07

申请号：US470483

申请日：1995-06-06

Applicant: Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

Inventor： Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

IPC: A61K35/74 ,  A61P31/04 ,  C12N1/20 ,  C12R1/245 ,  C12R1/25

CPC classification number: C12R1/245 ,  A61K35/747 ,  C12R1/25 ,  Y10S435/853 ,  Y10S435/856 ,  Y10S435/857

Abstract: A process for isolation of a strain of Lactobacillus having the ability of being established on human intestinal mucosa in vivo and being able to remain therein after oral administration for at least 10 days after the completion of the administration. By the process the new strains L. plantarum 299 (DSM 6595) and L. casei ssp. rhamnosus 271 (DSM 6594) have been isolated, which are useful for the prophylaxis or treatment of bacterial infections, especially in the form of a fermented nutrient composition.

Abstract translation: 一种用于分离具有在体内在人肠粘膜上建立的能力的乳杆菌菌株的方法，并且在施用完成后口服给药至少10天后能够保留在其中。 通过该过程，新菌株植物乳杆菌299（DSM 6595）和干酪乳杆菌 已经分离了鼠李糖271（DSM 6594），其可用于预防或治疗细菌感染，特别是以发酵营养组合物的形式。

公开(公告)号：US06287273B1

公开(公告)日：2001-09-11

申请号：US09357124

申请日：1999-07-20

Applicant: Mats Allers ,  Krasnodar Ivancev ,  Bengt Jeppson

Inventor： Mats Allers ,  Krasnodar Ivancev ,  Bengt Jeppson

IPC: A61M100

CPC classification number: A61M1/3621 ,  A61M1/3613 ,  A61M1/3615 ,  A61M25/1011 ,  A61M2025/1052 ,  A61M2025/1095 ,  A61M2210/1071

Abstract: A perfusion system for non-surgically isolating and perfusing an organ, particularly the liver (101), in a patient, and including; by-pass cathether apparatus having inlet and outlet lumens (111, 112) introducible into the blood vessels of the organ percutaneously and devised so as to by-pass the blood flow past the organ in a by-pass circuit; perfusion catheter apparatus having inlet and outlet lumens (114, 116) introducible into the blood vessels percutaneously and being devised so as to lead the flow of perfusion fluid in a perfusion circuit through the organ; occlusive seals (106, 108) for isolating the organ from the systemic blood flow; pump apparatus including a by-pass pump (261), a perfusion fluid pump (124) and a suction pump (134) for establishing a negative relative pressure at the perfusion outlet from the organ; and control apparatus (128) coupled to the pumps (124, 126, 134) so as to control the operation thereof such that the outflow of fluid from the organ exceeds the inflow of fluid into the organ in the perfusion circuit due to a net volume contribution of blood from the systemic circulation entering the isolated organ.

Abstract translation: 一种用于在患者中非手术分离和灌注器官，特别是肝脏（101）的灌注系统，并且包括： 具有通过经皮导入到所述器官的血管中的入口和出口腔（111,112）的旁路导管装置，设计成旁路通过所述器官的血流; 灌注导管装置，其具有入口和出口腔（114,116），其可经皮导入血管并设计成引导灌注回路中灌注流体通过所述器官的流动; 闭塞密封件（106,108），用于将器官与全身血流分离; 包括旁路泵（261），灌注流体泵（124）和抽吸泵（134），用于在器官的灌注出口处建立负相对压力; 和耦合到所述泵（124,126,134）的控制装置（128），以便控制其操作，使得来自所述器官的流体的流出超过由于净体积而在所述灌注回路中流体进入所述器官的流入 血液从系统循环中进入分离器官的贡献。

公开(公告)号：US5474932A

公开(公告)日：1995-12-12

申请号：US989030

申请日：1993-04-16

Applicant: Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

Inventor： Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

IPC: A61K35/74 ,  A61P31/04 ,  C12N1/20 ,  C12R1/245 ,  C12R1/25

CPC classification number: C12R1/245 ,  A61K35/747 ,  C12R1/25 ,  Y10S435/853 ,  Y10S435/856 ,  Y10S435/857

Abstract: A process for isolation of a strain of Lactobacillus having the ability of being established on human intestinal mucosa in vivo and being able to remain therein after oral administration for at least 10 days after the completion of the administration.By the process the new strains L. plantarum 299 (DSM 6595) and L. casei ssp. rhamnosus 271 (DSM 6594) have been isolated, which are useful for the prophylaxis or treatment of bacterial infections, especially in the form of a fermented nutrient composition.

Abstract translation: PCT No.PCT / SE92 / 00528 Sec。 371日期：1993年04月16日 102（e）日期1993年4月16日PCT提交1992年7月24日PCT公布。 出版物WO93 / 01823 日期：1993年2月4日。一种用于分离具有在体内在人肠粘膜上建立的能力的乳杆菌菌株的方法，并且在施用完成后至少10天口服后能够保留在其中。 通过该过程，新菌株植物乳杆菌299（DSM 6595）和干酪乳杆菌 已经分离了鼠李糖271（DSM 6594），其可用于预防或治疗细菌感染，特别是以发酵营养组合物的形式。

公开(公告)号：US5587314A

公开(公告)日：1996-12-24

申请号：US417770

申请日：1995-04-06

Applicant: Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

Inventor： Stig Bengmark ,  Siv Ahrne ,  Goran Molin ,  Bengt Jeppson

IPC: A61K35/74 ,  A61P31/04 ,  C12N1/20 ,  C12R1/245 ,  C12R1/25

CPC classification number: C12R1/245 ,  A61K35/747 ,  C12R1/25 ,  Y10S435/853 ,  Y10S435/856 ,  Y10S435/857

Abstract: A process for isolation of a strain of Lactobacillus having the ability of being established on human intestinal mucosa in vivo and being able to remain therein after oral administration for at least 10 days after the completion of the administration. By the process the new strains L. plantarum 299 (DSM 6595) and L. casei ssp. rhamnosus 271 (DSM 6594) have been isolated, which are useful for the prophylaxis or treatment of bacterial infections, especially in the form of a fermented nutrient composition.

Abstract translation: 一种用于分离具有在体内在人肠粘膜上建立的能力的乳杆菌菌株的方法，并且在施用完成后口服给药至少10天后能够保留在其中。 通过该过程，新菌株植物乳杆菌299（DSM 6595）和干酪乳杆菌 已经分离了鼠李糖271（DSM 6594），其可用于预防或治疗细菌感染，特别是以发酵营养组合物的形式。