Formulations including digestive enzymes, polysorbate-based surfactants and probiotics
    3.
    发明授权
    Formulations including digestive enzymes, polysorbate-based surfactants and probiotics 有权
    制剂包括消化酶,聚山梨醇酯类表面活性剂和益生菌

    公开(公告)号:US08722035B2

    公开(公告)日:2014-05-13

    申请号:US13267042

    申请日:2011-10-06

    摘要: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.

    摘要翻译: 公开了用于增强包括消化酶和益生菌微生物在内的益生菌微生物的体内定植的制剂和聚山梨酯表面活性剂。 酶包括促进益生菌乳杆菌生长的促生长酶制剂,促进双歧杆菌益生菌生长的双歧杆菌酶制剂以及有益于两种益生菌的组合制剂。 已经发现,当与酶制剂一起使用时,某些聚山梨醇酯表面活性剂,包括聚山梨酯-60和聚山梨酯-80,进一步促进益生菌微生物的生长。 制剂优选以干燥粉末形式混合,以避免与混合制剂中的水反应水。 这样的制剂可以包含在胶囊,片剂,包装或瓶子中,并且以顺序或一种组合的制剂口服给药。

    Methods for arousing dormant bacteria
    5.
    发明授权
    Methods for arousing dormant bacteria 有权
    引起休眠细菌的方法

    公开(公告)号:US06589771B1

    公开(公告)日:2003-07-08

    申请号:US09429199

    申请日:1999-10-28

    IPC分类号: C12N100

    摘要: A method for arousing dormant bacteria. The method comprises inducing diffusion of intracellular solutes from dormant bacteria and then allowing an adjustment period for a length of time sufficient to initiate arousal. The decrease in intracellular osmolality or pH can be induced by methods such as extraction, dilution, or dialysis. The method has been standardized using Dulbecco's phosphate buffered saline as the solution. The aroused bacteria can then be selected or recovered by growing them on media for a period of time. If the adjustment period is prolonged, many bacteria can become hypermutative.

    摘要翻译: 一种唤醒休眠细菌的方法。 该方法包括诱导来自休眠细菌的细胞内溶质的扩散,然后允许调整期限足以引发觉醒的一段时间。 可以通过提取,稀释或透析等方法诱导细胞内渗透压浓度或pH值的降低。 该方法已经使用Dulbecco的磷酸盐缓冲盐水作为溶液进行了标准化。 然后可以通过在培养基上培养它们一段时间来选择或回收所引起的细菌。 如果调整期延长,许多细菌可能变得过度活跃。

    Intestine colonizing strains of lactobacilli
    8.
    发明授权
    Intestine colonizing strains of lactobacilli 失效
    肠杆菌肠杆菌菌株

    公开(公告)号:US5474932A

    公开(公告)日:1995-12-12

    申请号:US989030

    申请日:1993-04-16

    摘要: A process for isolation of a strain of Lactobacillus having the ability of being established on human intestinal mucosa in vivo and being able to remain therein after oral administration for at least 10 days after the completion of the administration.By the process the new strains L. plantarum 299 (DSM 6595) and L. casei ssp. rhamnosus 271 (DSM 6594) have been isolated, which are useful for the prophylaxis or treatment of bacterial infections, especially in the form of a fermented nutrient composition.

    摘要翻译: PCT No.PCT / SE92 / 00528 Sec。 371日期:1993年04月16日 102(e)日期1993年4月16日PCT提交1992年7月24日PCT公布。 出版物WO93 / 01823 日期:1993年2月4日。一种用于分离具有在体内在人肠粘膜上建立的能力的乳杆菌菌株的方法,并且在施用完成后至少10天口服后能够保留在其中。 通过该过程,新菌株植物乳杆菌299(DSM 6595)和干酪乳杆菌 已经分离了鼠李糖271(DSM 6594),其可用于预防或治疗细菌感染,特别是以发酵营养组合物的形式。