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公开(公告)号：US20100105073A1
公开(公告)日：2010-04-29
申请号：US12603642
申请日：2009-10-22
IPC分类号： G01N33/53 , C12P21/08 , C12N5/0781
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及从免疫缺陷型非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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公开(公告)号：US20070266448A1
公开(公告)日：2007-11-15
申请号：US11801614
申请日：2007-05-08
IPC分类号： A01K67/027 , C12P21/04
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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3.发明授权Parathormone fragments, their preparation and medicaments containing these 失效parathormone片段，它们的制备和含有这些的药物
公开(公告)号：US5783558A
公开(公告)日：1998-07-21
申请号：US256363
申请日：1994-07-20
IPC分类号： A61K38/22 , A61K38/00 , A61P3/00 , A61P19/10 , A61P43/00 , C07K14/575 , C07K14/635 , A61K38/29
CPC分类号： C07K14/635 , A61K38/00
摘要： The invention concerns parathormone (PTH) fragments including the amino acid range of the natural parathormone of +3 to +35 and their physiologically compatible derivatives, a process for the preparation of the fragments according to the solid phase and liquid phase synthesis from partly blocked amino acids contained in the fragments which are coupled with one another in the sequence which corresponds to the amino acid sequence in the fragments to be prepared and medicaments containing at least one of the fragments, especially with calcium-regulating action in the body.
摘要翻译： PCT No.PCT / EP93 / 00259 Sec。 371日期：1994年7月20日 102（e）日期1994年7月20日PCT提交1993年2月4日PCT公布。 公开号WO93 / 15109 日期：1993年8月5日本发明涉及包含+3至+35的天然parathormone的氨基酸范围及其生理上相容的衍生物的parathormone（PTH）片段，根据固相和液相制备片段的方法 从与待制备的片段中的氨基酸序列相对应的序列中彼此偶联的片段中包含的部分封闭的氨基酸合成，以及含有至少一个片段的药物，特别是在 身体。
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公开(公告)号：US20120195903A1
公开(公告)日：2012-08-02
申请号：US13443917
申请日：2012-04-11
IPC分类号： A61K39/395 , C12N5/0781 , C12P21/08 , G01N33/577
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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