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    Micro- and nano-particulate drugs and methods of making thereof
    3.
    发明申请
    Micro- and nano-particulate drugs and methods of making thereof 审中-公开
    微粒和纳米颗粒药物及其制备方法

    公开(公告)号：US20080145438A1

    公开(公告)日：2008-06-19

    申请号：US11823476

    申请日：2007-06-26

    申请人： Beuford Arlie Bogue

    发明人： Beuford Arlie Bogue

    IPC分类号： A61K9/51 ,  A61K9/50 ,  A61P43/00 ,  A61K31/522

    CPC分类号： A61K31/522 ,  A61K9/5015 ,  A61K9/5146 ,  A61K9/5192

    摘要： A micro and nano-particulate drug comprising a drug substance and a surfactant in which the drug and surfactant form a eutectic mixture. The matrix formed between the drug substance and the surfactant has a melting point less than the decomposition temperature of the drug substance and thus provides the advantages of reduced irritation due to the melting process without the prior art problem of decomposition of the drug substance. In one embodiment, crystals are formed while the mixture is cooled at room temperature under high shear conditions. In a second embodiment, a flowable material may be formed which also contains the drug and that may be incorporated into a pharmaceutical delivery system is also disclosed. Methods of preparing the micro and nano-particulate drug crystals and non-crystalline substance are also contemplated in the inventive subject matter.

    摘要翻译： 包含药物和表面活性剂的微纳米颗粒药物，其中药物和表面活性剂形成共晶混合物。 在药物与表面活性剂之间形成的基质的熔点低于药物的分解温度，因此提供了由于熔融过程而导致的刺激性降低的优点，而没有现有技术的药物分解问题。 在一个实施方案中，形成晶体，同时在高剪切条件下将混合物在室温下冷却。 在第二个实施方案中，可以形成也含有药物的可流动的材料，并且还可以将其掺入到药物递送系统中。 在本发明的主题中也考虑了制备微纳米颗粒药物晶体和非结晶物质的方法。

    Amorphous drug beads
    4.
    发明授权
    Amorphous drug beads 失效
    无定形药物珠粒

    公开(公告)号：US07163700B2

    公开(公告)日：2007-01-16

    申请号：US10207975

    申请日：2002-07-31

    申请人： Beuford Arlie Bogue

    发明人： Beuford Arlie Bogue

    IPC分类号： A61K9/16 ,  A61K9/50

    CPC分类号： A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5042 ,  A61K9/5089

    摘要： The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.

    摘要翻译： 本发明主题涉及包含非晶形活性药物和具有改善的溶解性，吸收和润湿性特性的有机表面活性剂的无定形药物珠粒。 本发明的主题还涉及制备无定形药物珠粒的方法，其中熔融药物珠粒经受有或没有剪切的冷却步骤。