公开(公告)号：US20060169030A1

公开(公告)日：2006-08-03

申请号：US11298738

申请日：2005-12-09

Applicant: Larry Stewart ,  James Garvey ,  Jimmy Dzuong ,  Bijan Ghaderi ,  Christopher Janko

Inventor： Larry Stewart ,  James Garvey ,  Jimmy Dzuong ,  Bijan Ghaderi ,  Christopher Janko

IPC: G01N11/00

CPC classification number: G01N35/1095 ,  G01N1/10 ,  G01N1/16 ,  G01N1/26 ,  G01N1/38 ,  H01J49/04

Abstract: In one embodiment, an in-process mass spectrometry (IPMS) system is provided that includes: a plurality of sample mix modules, each sample mix module operable to select an extracted sample from a corresponding plurality of sample extraction modules, wherein each sample extraction module is operable to extract sample from a corresponding process solution bath having at least one analyte, each sample mix module being further operable to mix the selected extracted sample with a spike solution to form a mixture; a mass spectrometer operable to process the mixture from each sample mix module to form a mass spectral response having a spike response and an analyte response; and at least one processor operable to control the pluralities of sample extraction modules, the pluralities of sample mix modules, and the mass spectrometer such that the sample extraction modules automatically extract samples, the plurality of sample mix modules automatically mix the selected extracted samples with spike solution, and the mass spectrometer automatically process the mixtures, the at least one processor being further operable to characterize the concentration of the at least one analyte based upon a ratio measurement derived from the spike response and the analyte response.

Abstract translation: 在一个实施方案中，提供了一种过程中质谱（IPMS）系统，其包括：多个样品混合模块，每个样品混合模块可操作以从相应的多个样品提取模块中选择提取的样品，其中每个样品提取模块 可操作地从具有至少一种分析物的相应的处理溶液浴中提取样品，每个样品混合模块还可操作以将选定的提取样品与尖峰溶液混合以形成混合物; 质谱仪可操作以处理来自每个样品混合模块的混合物以形成具有尖峰响应和分析物响应的质谱响应; 以及至少一个处理器，其可操作以控制多个样品提取模块，多个样品混合模块和质谱仪，使得样品提取模块自动提取样品，多个样品混合模块自动将所选提取的样品与尖峰混合 溶液，并且所述质谱仪自动处理所述混合物，所述至少一个处理器还可操作以基于从所述尖峰响应和所述分析物响应得到的比率测量来表征所述至少一种分析物的浓度。

公开(公告)号：US20070141720A1

公开(公告)日：2007-06-21

申请号：US11305624

申请日：2005-12-16

Applicant: Larry Stewart ,  Jimmy Dzuong ,  Harmesh Saini ,  Quoc Truong ,  Hien Nguyen ,  Michael Ahern ,  Bijan Ghaderi

Inventor： Larry Stewart ,  Jimmy Dzuong ,  Harmesh Saini ,  Quoc Truong ,  Hien Nguyen ,  Michael Ahern ,  Bijan Ghaderi

IPC: G01N1/18

CPC classification number: B01J49/57 ,  B01J41/07 ,  B01J49/07 ,  G01N30/02 ,  Y10T436/255 ,  B01D15/363

Abstract: In one embodiment, a matrix elimination apparatus for eliminating an acidic matrix includes: at least one column packed with a weak anion exchange resin; a source of samples, each sample having an acidic matrix; a basic solution source; a weakly acidic metal complexing reagent source, and an at least one pump, wherein the matrix elimination apparatus is configured such that the at least one pump can sequence through the acts of: a) pumping the basic solution through the column to regenerate the column, b) pumping the weakly acid metal complexing reagent through the column to activate the column; and c) pumping one of the samples through the activated column to provide a processed sample whose acidic matrix is eliminated.

Abstract translation: 在一个实施方案中，用于消除酸性基质的基质消除装置包括：至少一个填充有弱阴离子交换树脂的柱; 样品来源，每个样品具有酸性基质; 一个基本的解决方案来源; 弱酸性金属络合试剂源和至少一个泵，其中所述基质消除装置被配置为使得所述至少一个泵可以顺序执行以下动作：a）将碱性溶液泵送通过柱以再生塔， b）将弱酸金属络合试剂泵送通过柱来活化柱; 和c）将一个样品泵送通过活化柱以提供其酸性基质被消除的经处理的样品。