公开(公告)号：US20100068314A1

公开(公告)日：2010-03-18

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US06852344B2

公开(公告)日：2005-02-08

申请号：US10207039

申请日：2002-07-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K36/00 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with the fractions used both individually, and in combination, and a composition including the fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，分别使用和组合使用，组合物包括分数nos。 1和9。

公开(公告)号：US06413553B1

公开(公告)日：2002-07-02

申请号：US09925415

申请日：2001-08-10

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharaya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharaya

IPC: A61K3578

CPC classification number: A61K36/67

Abstract: A pharmaceutical formulation is provided which is useful as a leukotrine synthesis and IL4 inhibitor and as a Th1 immunomodulator. The formulation comprises an effective amount of a combination of extracts and lyophilized extracts of Piper betel and Murrya koeniggi. The formulation can be formulated with pharmaceutically acceptable carriers. The formulation can be used in a method of treating humans for respiratory conditions.

Abstract translation: 提供了可用作白细胞素合成和IL4抑制剂和作为Th1免疫调节剂的药物制剂。 该制剂包含有效量的Pi bet提取物和冻干提取物的混合物。 制剂可以用药学上可接受的载体配制。 该制剂可用于治疗人类呼吸状况的方法。

公开(公告)号：US08029833B2

公开(公告)日：2011-10-04

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US07306817B2

公开(公告)日：2007-12-11

申请号：US10960064

申请日：2004-10-08

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A01N65/00

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water: methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用，组合物包含所述级分nos。 1和9。

公开(公告)号：US06967034B2

公开(公告)日：2005-11-22

申请号：US10448398

申请日：2003-05-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K36/67 ,  A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  Y10S514/908 ,  A61K2300/00

Abstract: A new herbal-based composition and method for treatment of CD33+ acute and chronic myeloid leukemia by Piper betel leaf extracts, and to provide a process for the isolation of active fractions from leaves or any other plant parts of Piper betel to treat CD33+ AML and CML with a simplified method of isolation of active components from all plant parts of Piper betel possessing biological activities relevant to the treatment of CD33+ AML and CML.

Abstract translation: 一种新的草药组合物和方法，用于通过per叶提取物治疗CD33 +急性和慢性骨髓性白血病，并提供从叶子或Piper槟榔的任何其他植物部分分离活性级分以处理CD33 + AML和CML的方法 采用简单的方法将活性成分从具有与治疗CD33 + AML和CML相关的生物活性的Piper槟榔的所有植物部分分离出来。

公开(公告)号：US07276258B2

公开(公告)日：2007-10-02

申请号：US10809645

申请日：2004-03-25

Applicant: Debleena Dey ,  Swapan Kumar Mandal ,  Mohua Mukherjee ,  Bikash Chandra Pal ,  Tanushree Biswas ,  Malabika Datta ,  Sib Sankar Roy ,  Arun Bandyopadhyay ,  Samir Bhattacharya ,  Bir Bhanu Giri ,  Santu Bandopadhyay ,  Aditya Konar

Inventor： Debleena Dey ,  Swapan Kumar Mandal ,  Mohua Mukherjee ,  Bikash Chandra Pal ,  Tanushree Biswas ,  Malabika Datta ,  Sib Sankar Roy ,  Arun Bandyopadhyay ,  Samir Bhattacharya ,  Bir Bhanu Giri ,  Santu Bandopadhyay ,  Aditya Konar

IPC: A01N65/00 ,  A61N43/04 ,  A61K31/70

CPC classification number: A61K31/70 ,  A61K36/488 ,  Y10S514/866

Abstract: The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.

Abstract translation: 本发明涉及预防和/或治疗糖尿病2型的方法，还涉及增加Glut4磷酸化和Glut4易位到靶细胞膜以增强信号转导途径中的胰岛素信号的方法; 此外，本发明涉及一种简单且便宜的获得提取物的方法，其后选择性地，其活性正丁醇级分和活性分子Lupinoside PA（LPA 4 S）可用于预防和/或治疗糖尿病2型 ; 最后是其药物组合物。

公开(公告)号：US07674487B2

公开(公告)日：2010-03-09

申请号：US11730433

申请日：2007-04-02

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US06773728B2

公开(公告)日：2004-08-10

申请号：US09985160

申请日：2001-11-01

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharya

IPC: A61K3578

CPC classification number: A61K36/67 ,  A61K36/75 ,  A61K2300/00

Abstract: This invention relates to an herbal composition for the treatment and remedy of bronchial respiratory difficulties, more particularly this invention describes the process of separation, physicochemical characterization and biological response evaluation of active components obtained from extracts of any plant parts including leaves, barks, roots and seeds of plants M. koenigii and P. betle in order to establish their role on the treatment and remedy of bronchial respiratory troubles.

Abstract translation: 本发明涉及用于治疗和补救支气管呼吸困难的草药组合物，更具体地，本发明描述了从任何植物部分（包括叶，树皮，根和根）的提取物获得的活性成分的分离过程，物理化学表征和生物反应评估， 植物M.koenigii和P. betle的种子，以确定其在支气管呼吸困难的治疗和补救方面的作用。

公开(公告)号：US06746694B1

公开(公告)日：2004-06-08

申请号：US09676502

申请日：2000-10-02

Applicant: Ranjan Bhadra ,  Bikash Chandra Pal ,  Krishna Das ,  Samir Bhattacharaya

Inventor： Ranjan Bhadra ,  Bikash Chandra Pal ,  Krishna Das ,  Samir Bhattacharaya

IPC: A61K3578

CPC classification number: A61K36/75

Abstract: The invention relates to a novel composition containing an extract obtained from the plant Murraya koenigii and useful for the treatment or providing relief from acute asthma, and a process for the preparation of a lyophilized extract containing active principles of the plant Murraya koenigii, and a method for the treatment of asthma.

Abstract translation: 本发明涉及一种含有从植物Murraya koenigii获得并可用于治疗或缓解急性哮喘的提取物的新型组合物，以及制备含有植物Murraya koenigii的活性成分的冻干提取物的方法，以及方法 用于治疗哮喘。