公开(公告)号：US20100068314A1

公开(公告)日：2010-03-18

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US06852344B2

公开(公告)日：2005-02-08

申请号：US10207039

申请日：2002-07-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K36/00 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with the fractions used both individually, and in combination, and a composition including the fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，分别使用和组合使用，组合物包括分数nos。 1和9。

公开(公告)号：US07674487B2

公开(公告)日：2010-03-09

申请号：US11730433

申请日：2007-04-02

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US20070184131A1

公开(公告)日：2007-08-09

申请号：US11730433

申请日：2007-04-02

Applicant: Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US20050282892A1

公开(公告)日：2005-12-22

申请号：US11174545

申请日：2005-07-06

Applicant: Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

Inventor： Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

IPC: A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/235 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06

CPC classification number: A61K31/235 ,  A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to a pharmaceutical composition useful for treating chronic myeloid leukemia where Bcr-Abl kinase is constitutively expressed in animals and humans, and a treatment of chronic myeloid leukemia (CML) by a composition comprising an effective amount of analogs and/or salts of chlorogenic acid. The analogs are preferably sodium chlorogenate (Na-Chl) or potassium or ammonium salts, which were prepared from Chlorogenic acid or its analogs.

Abstract translation: 本发明涉及一种用于治疗慢性骨髓性白血病的药物组合物，其中Bcr-Abl激酶在动物和人体中组成型表达，并且通过包含有效量的类似物和/或盐类型的组合物的组合物治疗慢性骨髓性白血病（CML） 绿原酸。 类似物优选由绿原酸或其类似物制备的氯酸钠（Na-Chl）或钾盐或铵盐。

公开(公告)号：US08029833B2

公开(公告)日：2011-10-04

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US07306817B2

公开(公告)日：2007-12-11

申请号：US10960064

申请日：2004-10-08

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A01N65/00

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water: methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用，组合物包含所述级分nos。 1和9。

公开(公告)号：US20070161704A1

公开(公告)日：2007-07-12

申请号：US11640401

申请日：2006-12-18

Applicant: Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

Inventor： Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

IPC: A61K31/235

CPC classification number: A61K31/235 ,  A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to a pharmaceutical composition useful for treating chronic myeloid leukemia where Bcr-Abl kinase is constitutively expressed in animals and humans, and a treatment of chronic myeloid leukemia (CML) by a composition comprising an effective amount of analogs and/or salts of chlorogenic acid. The analogs are preferably sodium chlorogenate (Na-Chl) or potassium or ammonium salts, which were prepared from Chlorogenic acid or its analogs.

Abstract translation: 本发明涉及一种用于治疗慢性骨髓性白血病的药物组合物，其中Bcr-Abl激酶在动物和人体中组成型表达，并且通过包含有效量的类似物和/或盐类型的组合物的组合物治疗慢性骨髓性白血病（CML） 绿原酸。 类似物优选由绿原酸或其类似物制备的氯酸钠（Na-Chl）或钾盐或铵盐。

公开(公告)号：US06967034B2

公开(公告)日：2005-11-22

申请号：US10448398

申请日：2003-05-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K36/67 ,  A61K31/215 ,  A61K31/366 ,  A61K31/37 ,  Y10S514/908 ,  A61K2300/00

Abstract: A new herbal-based composition and method for treatment of CD33+ acute and chronic myeloid leukemia by Piper betel leaf extracts, and to provide a process for the isolation of active fractions from leaves or any other plant parts of Piper betel to treat CD33+ AML and CML with a simplified method of isolation of active components from all plant parts of Piper betel possessing biological activities relevant to the treatment of CD33+ AML and CML.

Abstract translation: 一种新的草药组合物和方法，用于通过per叶提取物治疗CD33 +急性和慢性骨髓性白血病，并提供从叶子或Piper槟榔的任何其他植物部分分离活性级分以处理CD33 + AML和CML的方法 采用简单的方法将活性成分从具有与治疗CD33 + AML和CML相关的生物活性的Piper槟榔的所有植物部分分离出来。

公开(公告)号：US20050089585A1

公开(公告)日：2005-04-28

申请号：US10960064

申请日：2004-10-08

Applicant: Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K36/00 ,  A61K36/67 ,  A61K35/78 ,  C12Q1/68

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: The present invention relates to a method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract translation: 本发明涉及使用级分nos处理包括人在内的动物中的CD33 +急性和慢性骨髓性白血病的方法。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从piper槟的极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用，组合物包含所述级分nos。 1和9。