公开(公告)号：US08135548B2

公开(公告)日：2012-03-13

申请号：US11925689

申请日：2007-10-26

申请人： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

发明人： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

IPC分类号： G06F17/18

CPC分类号： H04B17/00 ,  A61B5/002 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B2560/0223 ,  G06F19/3418 ,  G16H40/67

摘要： A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a predetermined threshold level, and generating a first output signal associated with the verification of the presence of signal attenuation is provided. Also provided are systems and kits.

摘要翻译： 一种用于接收多个分析物传感器相关信号的计算机实现的方法，确定与所接收的多个分析物传感器相关信号相关联的信号衰减的概率，当确定的概率超过预定阈值水平时验证信号衰减的存在，以及生成 提供了与验证信号衰减的存在相关联的第一输出信号。 还提供系统和工具包。

公开(公告)号：US20080172205A1

公开(公告)日：2008-07-17

申请号：US11925689

申请日：2007-10-26

申请人： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

发明人： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

IPC分类号： G06F17/18 ,  G01N33/50

CPC分类号： H04B17/00 ,  A61B5/002 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B2560/0223 ,  G06F19/3418 ,  G16H40/67

摘要： Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.

摘要翻译： 提供实时检测分析物传感器灵敏度下降的方法，系统和计算机程序产品是连续的葡萄糖监测系统。

公开(公告)号：US20080154513A1

公开(公告)日：2008-06-26

申请号：US11943226

申请日：2007-11-20

申请人： Boris P. Kovatchev ,  David Price ,  Erik Otto ,  Alan Coulson

发明人： Boris P. Kovatchev ,  David Price ,  Erik Otto ,  Alan Coulson

IPC分类号： G06F17/18 ,  G01N33/48

CPC分类号： G06F19/3456 ,  G16H15/00 ,  G16H50/20

摘要： A method, system, and computer program product related to the maintenance of optimal control of diabetes, and is directed to predicting patterns of hypoglycemia, hyperglycemia, increased glucose variability, and insufficient or excessive testing for the upcoming period of time, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting and alerting the user to periods of increased risk for hyperglycemia, hypoglycemia, increased glucose variability, and ineffective testing, and to the enhancement of emerging self-monitoring blood glucose devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia, hypoglycemia, and increased glucose variability.

摘要翻译： 与维持糖尿病最佳控制相关的方法，系统和计算机程序产品，旨在预测低血糖，高血糖，葡萄糖变异性增加，以及基于血糖的即将到来时间的不足或过量测试 通过自我监测血糖仪收集的数据。 该方法，系统和计算机程序产品直接关系到现有家用血糖监测装置的增强，引入了智能数据解释组件，能够将用户预测和警告高血糖，低血糖，增加的葡萄糖变异性风险增加的时期， 和无效的测试，以及通过相同的特征增强新兴的自我监测血糖仪。 通过这些预测，糖尿病患者可以采取措施来预防与高血糖，低血糖和葡萄糖变异性增加相关的不良后果。

公开(公告)号：US07025425B2

公开(公告)日：2006-04-11

申请号：US10240228

申请日：2001-03-29

申请人： Boris P. Kovatchev ,  Daniel J. Cox

发明人： Boris P. Kovatchev ,  Daniel J. Cox

IPC分类号： A61B5/05

CPC分类号： G06F19/3418 ,  A61B5/0002 ,  A61B5/14532 ,  G06F19/00 ,  G16H10/40 ,  G16H10/60 ,  G16H50/50

摘要： A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of severe hypoglycemia in diabetics, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting both HbA1c and periods of increased risk of hypoglycemia, and to the enhancement of emerging continuous monitoring devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia and hypoglycemia.

摘要翻译： 一种与糖尿病诊断相关的方法，系统和计算机程序产品，旨在预测高血糖症的长期风险，糖尿病患者严重低血糖的长期和短期风险，基于血糖指标 通过自我监测血糖仪收集。 该方法，系统和计算机程序产品直接涉及现有家用血糖监测装置的增强，引入了一种智能数据解释组件，能够预测HbA 1c1和增加低血糖风险的时期， 并通过相同的功能来增强新兴的连续监控设备。 通过这些预测，糖尿病患者可以采取措施来预防与高血糖症和低血糖相关的不良后果。

公开(公告)号：US20130079613A1

公开(公告)日：2013-03-28

申请号：US13637359

申请日：2011-03-24

申请人： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek ,  Colleen H. Karvetski

发明人： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek ,  Colleen H. Karvetski

IPC分类号： A61B5/145 ,  A61M5/142 ,  A61M1/36 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7225 ,  A61B5/725 ,  A61B2560/0223 ,  A61M1/36 ,  A61M5/142

摘要： Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.

摘要翻译： 用于从胰岛素泵，人造胰腺或另一胰岛素递送装置提供信号的方法和系统作为用于提高连续葡萄糖传感器（CGS）的精度的信息来源。 使用胰岛素信息来提高传感器精度的效果在低血糖水平，即在降血糖范围内是最显着的，这在任何治疗中都是至关重要的。 一种用于提供可用于在时间t-τ确定葡萄糖状态估计的过滤/状态估计方法的系统。 估计可以外推到将来的某个时间t，然后外推值用于提取血糖分量。 对外推的血糖成分和CGS的输出进行加权，并用于估计受试者的血糖水平。

公开(公告)号：US08340752B2

公开(公告)日：2012-12-25

申请号：US12139976

申请日：2008-06-16

申请人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

发明人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

IPC分类号： A61B5/04

CPC分类号： A61B5/048 ,  A61B5/04842 ,  A61B5/168 ,  A61B5/4088 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726 ,  G06F19/00

摘要： A method, apparatus, and computer useable medium that provides, among other things, a standardized test protocol for screening and evaluation of attentional impairment using EEG data. Further, the method, apparatus, and computer program product enhances existing psychological, behavioral, and physiological EEG data acquisition systems by introducing a sequential stochastic model procedure, and an intelligent data interpretation component capable of assessing EEG inconsistencies associated attentional impairments. Potential users of this product will be any person or organization that diagnoses or treats persons with attentional or cognitive impairments. The method can be used for initial screening and diagnosis of disorders associated with impaired attention, such as ADHD, as well as for treatment and evaluation of the effects of treatments, such as medication or additional therapies.

摘要翻译： 一种方法，装置和计算机可用介质，其特别提供用于使用EEG数据筛选和评估注意力损伤的标准化测试协议。 此外，方法，装置和计算机程序产品通过引入顺序随机模型程序和能够评估与注意障碍相关的EEG不一致的智能数据解释组件来增强现有心理，行为和生理学EEG数据采集系统。 该产品的潜在用户将是诊断或治疗有注意力或认知障碍的人的任何个人或组织。 该方法可用于初步筛选和诊断与受关注的障碍相关的疾病，例如ADHD，以及治疗和评价治疗效果（如药物治疗或其他疗法）。

公开(公告)号：US20110264378A1

公开(公告)日：2011-10-27

申请号：US13131467

申请日：2009-11-24

申请人： Marc D. Breton ,  Boris P. Kovatchev

发明人： Marc D. Breton ,  Boris P. Kovatchev

IPC分类号： G06F19/00 ,  G01N33/48

CPC分类号： G16H40/63 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/7275 ,  G06F19/00 ,  G16H10/20 ,  G16H50/20

摘要： An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability.

摘要翻译： 一个实施方案可能在血糖分析和控制领域。 更具体地，实施例或方法可以提供用于从自我监测血糖（SMBG）数据和/或连续葡萄糖监测（CGM）数据来视觉和定量跟踪糖尿病血糖变异性的新方法，系统和计算机程序 。 更具体地，其实施方案或其方面可以使用从个体或一组个体的自我监测数据和/或CGM数据获得的葡萄糖测量值来跟踪和分析血糖变异性。

公开(公告)号：US07815569B2

公开(公告)日：2010-10-19

申请号：US11578831

申请日：2005-04-21

申请人： Boris P. Kovatchev ,  Linda Gonder-Frederick ,  Daniel J. Cox ,  William L. Clarke

发明人： Boris P. Kovatchev ,  Linda Gonder-Frederick ,  Daniel J. Cox ,  William L. Clarke

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B2560/0223

摘要： Continuous Glucose Error-Grid Analysis (CG-EGA) method, system or computer program product designed for evaluation of continuous glucose sensors providing frequent BG readings. The CG-EGA estimates the precision of such sensors/devices in terms of both BG values and temporal characteristics of BG fluctuation. The CG-EPA may account for, among other things, specifics of process characterization (location, speed and direction), and for biological limitations of the observed processes (time lags associated with interstitial sensors).

摘要翻译： 连续葡萄糖误差网格分析（CG-EGA）方法，系统或计算机程序产品，用于评估提供频繁BG读数的连续葡萄糖传感器。 根据BG值和BG波动的时间特性，CG-EGA估计这些传感器/设备的精度。 CG-EPA可以解释过程特征（位置，速度和方向）的细节以及观察到的过程（与间质传感器相关的时间滞后）的生物学限制。

公开(公告)号：US07761144B2

公开(公告)日：2010-07-20

申请号：US10592883

申请日：2005-03-17

申请人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

发明人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B19/00

CPC分类号： A61B5/7264 ,  A61B5/0484 ,  A61B5/168 ,  G06F19/00 ,  G06K9/6293 ,  Y10S128/92

摘要： A method, apparatus, and computer program product that provides, among other things, a procedure for the enhanced assessment of attention-related impairments of individuals. Further, the method, apparatus, and computer program product enhances existing assessment instruments by providing a way to reduce diagnostic error through the combining of the results of disparate assessment instruments. Potential users of this product will be any person or organization that diagnoses or treats persons with attentional or cognitive impairments. The method can be used for initial screening and diagnosis of disorders associated with impaired attention, such as ADHD, as well as for treatment and evaluation of the effects of treatments, such as medication or additional therapies.

摘要翻译： 一种方法，装置和计算机程序产品，其特别提供用于增强对个人注意力相关障碍的评估的程序。 此外，方法，设备和计算机程序产品通过结合不同的评估工具的结果提供了减少诊断错误的方法来增强现有的评估工具。 该产品的潜在用户将是诊断或治疗有注意力或认知障碍的人的任何个人或组织。 该方法可用于初步筛选和诊断与受关注的障碍相关的疾病，例如ADHD，以及治疗和评价治疗效果（如药物治疗或其他疗法）。

公开(公告)号：US20080220400A1

公开(公告)日：2008-09-11

申请号：US10592883

申请日：2005-03-17

申请人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

发明人： Daniel J. Cox ,  Boris P. Kovatchev ,  Rayna S. Robeva ,  Jennifer Kim Penberthy

IPC分类号： A61B5/00

CPC分类号： A61B5/7264 ,  A61B5/0484 ,  A61B5/168 ,  G06F19/00 ,  G06K9/6293 ,  Y10S128/92

摘要： A method, apparatus, and computer program product that provides, among other things, a procedure for the enhanced assessment of attention-related impairments of individuals. Further, the method, apparatus, and computer program product enhances existing assessment instruments by providing a way to reduce diagnostic error through the combining of the results of disparate assessment instruments. Potential users of this product will be any person or organization that diagnoses or treats persons with attentional or cognitive impairments. The method can be used for initial screening and diagnosis of disorders associated with impaired attention, such as ADHD, as well as for treatment and evaluation of the effects of treatments, such as medication or additional therapies.

摘要翻译： 一种方法，装置和计算机程序产品，其特别提供用于增强对个人注意力相关障碍的评估的程序。 此外，方法，设备和计算机程序产品通过结合不同的评估工具的结果提供了减少诊断错误的方法来增强现有的评估工具。 该产品的潜在用户将是诊断或治疗有注意力或认知障碍的人的任何个人或组织。 该方法可用于初步筛选和诊断与受关注的障碍相关的疾病，例如ADHD，以及治疗和评价治疗效果（如药物治疗或其他疗法）。