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公开(公告)号:US09035037B2
公开(公告)日:2015-05-19
申请号:US12809941
申请日:2008-12-22
CPC分类号: A61K38/08 , A61K9/0051 , A61K38/10 , A61K38/385 , A61L17/005 , A61L27/54 , A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/608
摘要: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.
摘要翻译: 包括适合引入受试者的抗连接蛋白剂的医疗装置。
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公开(公告)号:US08975237B2
公开(公告)日:2015-03-10
申请号:US12809886
申请日:2008-12-22
CPC分类号: C12N15/113 , A61K31/7088 , A61K45/06 , A61L15/44 , A61L26/0066 , A61L2300/258 , A61L2300/432 , C12N15/1138 , C12N2310/11 , C12N2310/315 , Y02A50/423
摘要: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.
摘要翻译: 纤维化和纤维化疾病,病症和病症以及相关方法,组合物,制剂和制品的治疗。
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公开(公告)号:US20110217313A1
公开(公告)日:2011-09-08
申请号:US12809902
申请日:2008-12-22
IPC分类号: A61K39/395 , A61P41/00 , A61K31/7088 , A61K38/02 , A61P17/02 , A61P19/02
CPC分类号: C12N15/1138 , A61K38/177 , C12N2310/11 , C12N2320/31 , A61K2300/00
摘要: Methods, compounds, compositions, kits and articles of manufacture comprising anti-connexin agents for treatment of orthopedic disorder, disease, or condition, and promoting post-surgical wound-healing.
摘要翻译: 方法,化合物,组合物,试剂盒和制品,其包含用于治疗矫形障碍,疾病或病症的抗连接蛋白剂,以及促进手术后伤口愈合。
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公开(公告)号:US20110136890A1
公开(公告)日:2011-06-09
申请号:US12809886
申请日:2008-12-22
CPC分类号: C12N15/113 , A61K31/7088 , A61K45/06 , A61L15/44 , A61L26/0066 , A61L2300/258 , A61L2300/432 , C12N15/1138 , C12N2310/11 , C12N2310/315 , Y02A50/423
摘要: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.
摘要翻译: 纤维化和纤维化疾病,病症和病症以及相关方法,组合物,制剂和制品的治疗。
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公开(公告)号:US20110130710A1
公开(公告)日:2011-06-02
申请号:US12809916
申请日:2008-12-22
IPC分类号: A61K31/7088 , A61P17/02 , C12Q1/68 , A61B17/3205 , A61M35/00
CPC分类号: A61K31/7088 , C12N15/1138 , C12N2310/11 , G01N33/5008
摘要: Methods, compounds, compositions, kits and articles of manufacture comprising anti-connexin polynucleotides for prevention and/or treatment of abnormal scars, including keloid scars, hypertrophic scars, atrophic scars, and widespread scars.
摘要翻译: 包括用于预防和/或治疗异常瘢痕的抗连接蛋白多核苷酸的方法,化合物,组合物,试剂盒和制品,包括瘢痕疙瘩,肥大性瘢痕,萎缩性瘢痕和广泛的瘢痕。
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公开(公告)号:US20110092449A1
公开(公告)日:2011-04-21
申请号:US12809974
申请日:2008-12-22
申请人: Bradford James Duft
发明人: Bradford James Duft
IPC分类号: A61K38/16 , A61K38/02 , A61K31/7088 , A61K38/10 , A61P43/00
CPC分类号: C12N15/1138 , A61K38/177 , C12N2310/11 , A61K2300/00
摘要: Compositions, articles, devices and methods for the treatment of fibrosis and fibrotic diseases, disorders, and conditions in humans and non-human animals.
摘要翻译: 用于治疗人和非人动物中的纤维化和纤维化疾病,病症和病症的组合物,制品,装置和方法。
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公开(公告)号:US20130184220A1
公开(公告)日:2013-07-18
申请号:US12809986
申请日:2008-12-22
申请人: Bradford James Duft
发明人: Bradford James Duft
IPC分类号: A61K38/10 , C07K7/08 , A61K31/713
CPC分类号: A61K38/10 , A61K9/0014 , A61K31/713 , A61K38/177 , A61K47/38 , A61L15/44 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , C07K7/08 , C07K14/78 , C12N15/1138 , C12N2310/11 , A61K2300/00
摘要: Methods and compositions comprising combinations and uses of a first anti-connexin agent and a second anti-connexin agent, for example, one or more anti-connexin polynucleotides and one or more anti-connexin peptides or peptidomimetics, are provided for the treatmen or prevention of abnormal or excessive scarring.
摘要翻译: 提供了包含第一抗连接蛋白剂和第二抗连接蛋白剂的组合和用途的方法和组合物,例如一种或多种抗连接蛋白多核苷酸和一种或多种抗连接蛋白肽或肽模拟物,用于治疗或预防 异常或过度瘢痕形成。
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公开(公告)号:US20110038920A1
公开(公告)日:2011-02-17
申请号:US12812017
申请日:2009-01-07
申请人: Ryoichi Mori , Paul Martin , Bradford James Duft , Tanya Shaw
发明人: Ryoichi Mori , Paul Martin , Bradford James Duft , Tanya Shaw
IPC分类号: A61K31/713 , C07H21/02 , A61K9/70 , A61P29/00 , A61P17/02
CPC分类号: C12N15/1136 , C12N2310/11 , C12N2310/14
摘要: Methods and compositions comprising an anti-ostepontin agent and/or a PDGF receptor blocker or antagonist, alone or in combination with one or more anti-connexin agents, for example, one or more anti-connexin polynucleotides and/or one or more anti-connexin peptides or peptidomimetics, are provided for the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.
摘要翻译: 包含单独或与一种或多种抗连接蛋白试剂,例如一种或多种抗连接蛋白多核苷酸和/或一种或多种抗连接蛋白多核苷酸组合的抗 - 奥替替药物和/或PDGF受体阻断剂或拮抗剂的方法和组合物, 连接蛋白肽或肽模拟物用于促进和/或改善伤口愈合和/或组织修复,以及用于抗瘢痕形成,抗炎,抗纤维化和抗粘连的适应症。
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公开(公告)号:US20160264977A1
公开(公告)日:2016-09-15
申请号:US14777458
申请日:2014-03-15
发明人: Anthony PHILLIPS , David EISENBUD , Scott BANNAN , David POOL , Grove MATSUOKA , Tracey SUNDERLAND , Bradford James DUFT
IPC分类号: C12N15/113 , A61K47/10 , A61B5/00 , A61K47/38 , A61K31/7105 , A61K9/00 , A61K9/06
CPC分类号: A61K31/7088 , A61B5/0064 , A61B5/0077 , A61B5/1072 , A61B5/1079 , A61B5/1109 , A61B5/445 , A61B5/4839 , A61B5/4848 , A61B5/7275 , A61B2503/40 , A61K9/0014 , A61K9/06 , A61K9/70 , A61K31/7105 , A61K47/00 , A61K47/10 , A61K47/38 , A61K48/00 , C07K14/47 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2320/35
摘要: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
摘要翻译: 本发明涉及通过施用抗连接蛋白剂,特别是抗连接蛋白43反义多核苷酸治疗慢性伤口的改进的方法,用途和试剂盒。 本发明的方法,用途和试剂盒基于惊人的和意想不到的发现,即在预处理阶段期间,不增加或减少大小超过预定量的慢性伤口比成功治疗更适合于比 在预处理阶段,其大小在目标范围之外变化的伤口。
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公开(公告)号:US20110300130A1
公开(公告)日:2011-12-08
申请号:US12747501
申请日:2008-12-11
IPC分类号: A61K39/395 , A61P43/00 , A61P17/02 , A61K38/02
CPC分类号: C07K14/78
摘要: Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.
摘要翻译: 方法,化合物,组合物,试剂盒和制品,其包含一种或多种间隙连接调节剂,用于治疗以预期速率不愈合的伤口,包括慢性伤口,延迟愈合伤口,不完全愈合的伤口和受试者的开裂伤口 需要。
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