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公开(公告)号:US20160264977A1
公开(公告)日:2016-09-15
申请号:US14777458
申请日:2014-03-15
发明人: Anthony PHILLIPS , David EISENBUD , Scott BANNAN , David POOL , Grove MATSUOKA , Tracey SUNDERLAND , Bradford James DUFT
IPC分类号: C12N15/113 , A61K47/10 , A61B5/00 , A61K47/38 , A61K31/7105 , A61K9/00 , A61K9/06
CPC分类号: A61K31/7088 , A61B5/0064 , A61B5/0077 , A61B5/1072 , A61B5/1079 , A61B5/1109 , A61B5/445 , A61B5/4839 , A61B5/4848 , A61B5/7275 , A61B2503/40 , A61K9/0014 , A61K9/06 , A61K9/70 , A61K31/7105 , A61K47/00 , A61K47/10 , A61K47/38 , A61K48/00 , C07K14/47 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2320/35
摘要: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
摘要翻译: 本发明涉及通过施用抗连接蛋白剂,特别是抗连接蛋白43反义多核苷酸治疗慢性伤口的改进的方法,用途和试剂盒。 本发明的方法,用途和试剂盒基于惊人的和意想不到的发现,即在预处理阶段期间,不增加或减少大小超过预定量的慢性伤口比成功治疗更适合于比 在预处理阶段,其大小在目标范围之外变化的伤口。
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公开(公告)号:US20160339052A1
公开(公告)日:2016-11-24
申请号:US15076513
申请日:2016-03-21
发明人: Anthony PHILLIPS , David EISENBUD , Scott BANNAN , Grove MATSUOKA , David POOL , Tracey SUNDERLAND , Bradford DUFT
IPC分类号: A61K31/7088 , A61K9/00 , A61B5/107 , A61K9/06 , A61K9/70 , A61B5/00 , C12N15/113 , A61K47/10
CPC分类号: A61K31/7088 , A61B5/0064 , A61B5/0077 , A61B5/1072 , A61B5/1079 , A61B5/1109 , A61B5/445 , A61B5/4839 , A61B5/4848 , A61B5/7275 , A61B2503/40 , A61K9/0014 , A61K9/06 , A61K9/70 , A61K31/7105 , A61K47/00 , A61K47/10 , A61K47/38 , A61K48/00 , C07K14/47 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2320/35
摘要: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
摘要翻译: 本发明涉及通过施用抗连接蛋白剂,特别是抗连接蛋白43反义多核苷酸治疗慢性伤口的改进的方法,用途和试剂盒。 本发明的方法,用途和试剂盒基于惊人的和意想不到的发现,即在预处理阶段期间,不增加或减少大小超过预定量的慢性伤口比成功治疗更适合于比 在预处理阶段,其大小在目标范围之外变化的伤口。
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公开(公告)号:US20140275218A1
公开(公告)日:2014-09-18
申请号:US14214922
申请日:2014-03-15
发明人: Anthony PHILLIPS , David EISENBUD , Scott BANNAN , David POOL , Grove MATSUOKA , Tracey SUNDERLAND , Bradford DUFT
CPC分类号: A61K31/7088 , A61B5/0064 , A61B5/0077 , A61B5/1072 , A61B5/1079 , A61B5/1109 , A61B5/445 , A61B5/4839 , A61B5/4848 , A61B5/7275 , A61B2503/40 , A61K9/0014 , A61K9/06 , A61K9/70 , A61K31/7105 , A61K47/00 , A61K47/10 , A61K47/38 , A61K48/00 , C07K14/47 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2320/35
摘要: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
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