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公开(公告)号:US20190225602A1
公开(公告)日:2019-07-25
申请号:US16372189
申请日:2019-04-01
申请人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
发明人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
IPC分类号: C07D417/12 , C07D213/75 , C07D409/12
摘要: Provided herein are methods for antagonizing the action of an α4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula I where R1, R2, R3, R4, R5, X and R6 are as described herein.
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公开(公告)号:US20100029753A1
公开(公告)日:2010-02-04
申请号:US12183032
申请日:2008-07-30
申请人: Eric C. Anderson , Ronald J. Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
发明人: Eric C. Anderson , Ronald J. Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
IPC分类号: A61K31/381 , C07D333/42 , A61P37/06
CPC分类号: C07D333/38 , C07D333/70 , C07D409/12 , C07D495/04
摘要: Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.
摘要翻译: 提供的是CCR9受体活性调节剂的化合物,含有化合物的组合物和使用该化合物和组合物的方法。 在某些实施方案中,提供了用于治疗或改善与调节CCR9受体活性相关的疾病的方法。
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公开(公告)号:US20180312498A1
公开(公告)日:2018-11-01
申请号:US15497416
申请日:2017-04-26
申请人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
发明人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
IPC分类号: C07D417/12 , C07D213/75
CPC分类号: C07D417/12 , C07D213/75
摘要: Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5, X and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an α4-integrin to treat various pathophysiological conditions.
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公开(公告)号:US08178699B2
公开(公告)日:2012-05-15
申请号:US12183032
申请日:2008-07-30
申请人: Eric C Anderson , Ronald J Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
发明人: Eric C Anderson , Ronald J Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
IPC分类号: C07D333/56
CPC分类号: C07D333/38 , C07D333/70 , C07D409/12 , C07D495/04
摘要: Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.
摘要翻译: 提供的是CCR9受体活性调节剂的化合物,含有化合物的组合物和使用该化合物和组合物的方法。 在某些实施方案中,提供了用于治疗或改善与调节CCR9受体活性相关的疾病的方法。
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公开(公告)号:US10246451B2
公开(公告)日:2019-04-02
申请号:US15497416
申请日:2017-04-26
申请人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
发明人: Ronald J. Biediger , Michele A. Benish , Robert V. Market , Michael M. Savage , Brandon M. Young
IPC分类号: C07D213/75 , C07D417/12 , A61K31/44
摘要: Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5, X and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an α4-integrin to treat various pathophysiological conditions.
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公开(公告)号:US20180312523A1
公开(公告)日:2018-11-01
申请号:US15497414
申请日:2017-04-26
申请人: Ronald J. Biediger , Michele A. Benish , Lindsay Bonner Hardy , Vincent A. Boyd , Robert V. Market , Thomas P. Thrash , Brandon M. Young
发明人: Ronald J. Biediger , Michele A. Benish , Lindsay Bonner Hardy , Vincent A. Boyd , Robert V. Market , Thomas P. Thrash , Brandon M. Young
IPC分类号: C07D498/04 , C07D213/75 , C07D213/64 , C07D207/327 , C07C69/618 , C07D307/54 , C07D401/12 , C07D221/18 , C07D207/333 , C07C313/06 , C07D333/22 , C07D231/16 , C07D471/04 , C07D261/08 , C07D213/55 , C07D213/48 , C07D213/69 , C07C47/575 , C07C47/55 , C07D209/08 , C07D237/14
摘要: Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.
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