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公开(公告)号：US08178699B2
公开(公告)日：2012-05-15
申请号：US12183032
申请日：2008-07-30
申请人： Eric C Anderson , Ronald J Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
发明人： Eric C Anderson , Ronald J Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
IPC分类号： C07D333/56
CPC分类号： C07D333/38 , C07D333/70 , C07D409/12 , C07D495/04
摘要： Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.
摘要翻译： 提供的是CCR9受体活性调节剂的化合物，含有化合物的组合物和使用该化合物和组合物的方法。 在某些实施方案中，提供了用于治疗或改善与调节CCR9受体活性相关的疾病的方法。
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公开(公告)号：US20100029753A1
公开(公告)日：2010-02-04
申请号：US12183032
申请日：2008-07-30
申请人： Eric C. Anderson , Ronald J. Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
发明人： Eric C. Anderson , Ronald J. Biediger , Jie Chen , Brian Dupre , Pedro Lory , Robert V. Market , Keith A. Monk , Michael M. Savage , Reginald Tennyson , Brandon M. Young
IPC分类号： A61K31/381 , C07D333/42 , A61P37/06
CPC分类号： C07D333/38 , C07D333/70 , C07D409/12 , C07D495/04
摘要： Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modulation of CCR9 receptor activity.
摘要翻译： 提供的是CCR9受体活性调节剂的化合物，含有化合物的组合物和使用该化合物和组合物的方法。 在某些实施方案中，提供了用于治疗或改善与调节CCR9受体活性相关的疾病的方法。
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3.发明申请Substrate peptide sequences for plague plasminogen activator and uses thereof 审中-公开用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US20120045474A1
公开(公告)日：2012-02-23
申请号：US13199407
申请日：2011-08-29
IPC分类号： A61K39/02 , A61K38/08 , A61K38/07 , A61K38/06 , A61P31/04 , C40B30/08 , C07C225/18 , C07C61/08 , C07C63/49 , C07D409/12 , C07D333/36 , C07K7/06 , C07K5/11 , C07K5/09 , A61P37/04 , C12Q1/37
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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4.发明申请Substrate peptide sequences for plague plasminogen activator and uses thereof 有权用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US20090069248A1
公开(公告)日：2009-03-12
申请号：US11901978
申请日：2007-09-20
IPC分类号： C12Q1/37 , C07K7/06 , A61K38/02 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/08 , C07K5/10 , A61P31/04
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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公开(公告)号：US09187523B2
公开(公告)日：2015-11-17
申请号：US13199407
申请日：2011-08-29
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
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6.发明授权Substrate peptide sequences for plague plasminogen activator and uses thereof 有权用于瘟疫纤溶酶原激活物的底物肽序列及其用途公开(公告)号：US08030447B2
公开(公告)日：2011-10-04
申请号：US11901978
申请日：2007-09-20
IPC分类号： C07K7/06
CPC分类号： C07K5/1019 , A61K38/00 , C07K5/06095 , C07K5/0817 , C07K7/06 , C12Q1/37 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
摘要翻译： 本发明涉及从组合文库鉴定并可用作瘟疫纤溶酶原激活物（Pla）的底物的肽序列。 本发明的另一方面涉及由于导致Pla的蛋白水解活性的特异性失活的化学修饰而导致的Pla的底物衍生的肽。 此外，本发明涉及本文所鉴定的底物在检测表达包括鼠疫菌的蛋白酶家族的细菌的用途中的用途。 此外，本发明还涉及本文鉴定的抑制剂在预防和治疗由这些细菌引起的感染中的用途。
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