公开(公告)号：US08247238B2

公开(公告)日：2012-08-21

申请号：US13217616

申请日：2011-08-25

申请人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

发明人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

IPC分类号： G01N21/75

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

摘要翻译： 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。 分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

公开(公告)号：US08431409B1

公开(公告)日：2013-04-30

申请号：US13564698

申请日：2012-08-01

申请人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

发明人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

IPC分类号： G01N21/75

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

公开(公告)号：US20100210029A1

公开(公告)日：2010-08-19

申请号：US12597742

申请日：2008-04-25

申请人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan G. Santiago

发明人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan G. Santiago

IPC分类号： G01N21/65 ,  G01N27/26

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

摘要翻译： 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。 分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

公开(公告)号：US20130121884A1

公开(公告)日：2013-05-16

申请号：US13564698

申请日：2012-08-01

申请人： Carl Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

发明人： Carl Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

IPC分类号： G01N21/65

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

公开(公告)号：US20120148451A1

公开(公告)日：2012-06-14

申请号：US13217616

申请日：2011-08-25

申请人： Carl Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

发明人： Carl Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan Santiago

IPC分类号： G01N21/65

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

摘要翻译： 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。 分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

公开(公告)号：US08017408B2

公开(公告)日：2011-09-13

申请号：US12597742

申请日：2008-04-25

申请人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan G. Santiago

发明人： Carl D. Meinhart ,  Brian Piorek ,  Seung Joon Lee ,  Martin Moskovits ,  Sanjoy Banerjee ,  Juan G. Santiago

IPC分类号： G01N21/75

CPC分类号： G01N21/658 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/0057 ,  G01N2021/0346 ,  G01N2201/06113 ,  G01N2201/1087 ,  Y10S977/902

摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

摘要翻译： 提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。 分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。 自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。 自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。 微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。