摘要:
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要:
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要:
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要:
Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要:
Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.
摘要:
Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.
摘要:
For a rapid and real-time SERS detection of organic chemicals in the air and the interfaces of air/solids, colloidal silver and/or gold nanoparticles solution is sprayed, in the form of nano-/micro-sized droplets, at the desired target area where the analytes of interest are present, e.g., in the air or onto certain organic/inorganic interfaces.
摘要:
A series of electronic-chemometric control processes to enhance the selectivity, concentration, analysis, and detec tion of chemical species (analytes) in the gas phase, such as when using SERS-based techniques. Controls consist variously of: 1) feedback of electronic signals corresponding to changes of static and variable parameters in targeted chemical species that vary according to a reduction, increase, maximization, linearization, or improved confidence in one or more chemometric output parameters; 2) methods for spatially locating the source of an analyte species; and, 3) variable duty cycling to save power and materials according to altered physical and environmental conditions within a monitored zone.
摘要:
Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.
摘要:
Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.