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1.发明授权Method of using lectins for contraception, prophylaxis against diseases transmittable by sexual contact, and therapy of such diseases, and apparatus for administering lectins 失效使用凝集素进行避孕的方法，通过性接触传播的疾病的预防和这些疾病的治疗，以及用于施用凝集素的装置公开(公告)号：US06743773B2
公开(公告)日：2004-06-01
申请号：US10259610
申请日：2002-09-30
申请人： Michael J. Oldham , Bruce F. Rose
发明人： Michael J. Oldham , Bruce F. Rose
IPC分类号： A01N3718
CPC分类号： A61K38/17 , A61F6/08 , A61K38/168 , A61K38/1709 , Y10S424/14 , Y10S514/841 , Y10S514/843 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/953 , Y10S514/967 , Y10T428/31971
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
摘要翻译： 为了防止性传播疾病（STD's）的受孕和/或扩散，可以在性交前向阴道施用一种或多种能够结合精子和/或负责STD的病原微生物的凝集素。 凝集素固定精子使其不能施肥，并且还结合微生物使其成为非致病性或细胞以防止微生物感染。 也可以施用凝露素治疗性传播的阴道感染。 本发明还包括用于放置在阴道的拱顶中的装置，其包括围绕子宫颈的环和横跨环的中心孔的膜，以防止射精与子宫颈组织的直接接触。 该装置浸渍或涂有凝集素，并在一段时间内将其释放到阴道环境中。
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2.发明授权Method of using lectins for contraception and prophylaxis against diseases transmittable by sexual contact and condom containing lectins 失效使用凝集素进行避孕和预防通过性接触传播的疾病和含有凝集素的避孕套的方法
公开(公告)号：US6074671A
公开(公告)日：2000-06-13
申请号：US97669
申请日：1998-06-16
CPC分类号： A61F6/08 , A61K38/168 , A61K38/1709
摘要： In order to prevent conception and/or infection by sexually transmitted diseases (STDs) one or more lectins capable of binding sperm or agglutinable components of male ejaculate and/or the pathogenic microorganisms responsible for STDs or the carbohydrate moieties expressed on cell surfaces by which the microorganisms bind to the cells, are administered to the vagina prior to sexual intercourse. The lectins prevent conception by binding to the sperm or agglutinable components of male ejaculate to render the sperm incapable of fertilization. They also bind to the pathogenic microorganisms to render them non-pathogenic or to carbohydrates expressed on cell surfaces to prevent infection by the microorganisms or treat such infections. Lectins can also be administered to treat sexually transmitted vaginal infections. The lectins can also be applied to or contained within a condom. The condom may carry the lectins either within the hollow interior of the condom or impregnated into, linked to, or coated upon its membrane body. Lectins may also be incorporated in the same way into a surgical glove for protection against infection by pathogenic microorganisms.
摘要翻译： 为了防止性传播疾病（STD）的受孕和/或感染，一种或多种凝集素能够结合雄性射精精子或可凝结组分和/或负责STD的病原微生物或细胞表面上表达的碳水化合物部分， 微生物结合细胞，在性交前施用于阴道。 凝集素通过与男性射精的精子或可凝结成分结合来预防受孕，使精子无能力受精。 它们还结合致病微生物使其非致病性或在细胞表面上表达的碳水化合物以防止微生物感染或治疗这些感染。 也可以施用凝露素治疗性传播的阴道感染。 凝集素也可以应用于或包含在避孕套内。 避孕套可以在避孕套的中空内部携带凝集素，或浸入，连接到或涂覆在其膜体上。 胶质素也可以以相同的方式并入手术手套中，以防止致病微生物感染。
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3.发明授权Prophylaxis against diseases tramsmittable by sexual contact, and therapy of such diseases 失效预防通过性接触传播的疾病和治疗这些疾病
公开(公告)号：US5840771A
公开(公告)日：1998-11-24
申请号：US938831
申请日：1997-09-26
申请人： Michael J. Oldham , Bruce F. Rose
发明人： Michael J. Oldham , Bruce F. Rose
CPC分类号： A61K38/17 , A61F6/08 , A61K38/168 , A61K38/1709 , Y10S424/14 , Y10S514/841 , Y10S514/843 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/953 , Y10S514/967 , Y10T428/31971
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
摘要翻译： 为了防止性传播疾病（STD's）的受孕和/或扩散，可以在性交前向阴道施用一种或多种能够结合精子和/或负责STD的病原微生物的凝集素。 凝集素固定精子使其不能施肥，并且还结合微生物使其成为非致病性或细胞以防止微生物感染。 也可以施用凝露素治疗性传播的阴道感染。 本发明还包括用于放置在阴道的拱顶中的装置，其包括围绕子宫颈的环和横跨环的中心孔的膜，以防止射精与子宫颈组织的直接接触。 该装置浸渍或涂有凝集素，并在一段时间内将其释放到阴道环境中。
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4.发明授权
公开(公告)号：US5295984A
公开(公告)日：1994-03-22
申请号：US904367
申请日：1992-06-26
CPC分类号： A61K9/0036 , A61F5/4553 , A61B2010/0074
摘要： A vaginal discharge collection device is formed of an elastomeric rim and a flexible film reservoir. The rim may have a generally rectangular cross section and forms a collection space for collecting vaginal discharge. The reservoir may be collapsible so as to be substantially enclosed within the rim when the device is being used. Advantageously, the rim and the reservoir are arranged such that compressing diametrically opposed portions of the rim toward each other causes a leading portion of the rim to dip downwardly to facilitate insertion of the device. The device is ergonomically constructed so as to be convenient to use, comfortable to wear internally, and reliable. A system for reliably, comfortably and conveniently introducing agents, including drugs and other substances, into the vaginal canal is also disclosed.
摘要翻译： 阴道排出物收集装置由弹性边缘和柔性膜储存器形成。 轮辋可以具有大致矩形的横截面并且形成用于收集阴道排泄物的收集空间。 储存器可以是可折叠的，以便当使用该装置时基本上封闭在边缘内。 有利地，边缘和储存器布置成使得边缘朝向彼此压缩直径相对的部分使得边缘的引导部分向下倾斜以便于装置的插入。 该设备符合人体工程学设计，使用方便，内部佩戴舒适，可靠。 还公开了用于可靠，舒适和方便地将药剂（包括药物和其他物质）引入阴道内的系统。
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公开(公告)号：US6066338A
公开(公告)日：2000-05-23
申请号：US94679
申请日：1998-06-15
CPC分类号： A61K38/17 , A61F6/08 , A61K38/168 , A61K38/1709 , Y10S424/14 , Y10S514/841 , Y10S514/843 , Y10S514/953 , Y10S514/967
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections.The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
摘要翻译： 为了防止性传播疾病（STD's）的受孕和/或扩散，可以在性交前向阴道施用一种或多种能够结合精子和/或负责STD的病原微生物的凝集素。 凝集素固定精子使其不能受精，并且还结合微生物使其成为非致病性或细胞以防止微生物感染。 也可以施用凝露素治疗性传播的阴道感染。 本发明还包括用于放置在阴道的拱顶中的装置，其包括围绕子宫颈的环和横跨环的中心孔的膜，以防止射精与子宫颈组织的直接接触。 该装置浸渍或涂有凝集素，并在一段时间内将其释放到阴道环境中。
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公开(公告)号：US6159174A
公开(公告)日：2000-12-12
申请号：US199045
申请日：1998-11-24
CPC分类号： A61F6/08 , A61K38/168 , A61K38/17 , A61K38/1709 , Y10S424/14 , Y10S514/931 , Y10S514/933 , Y10S514/934 , Y10S514/967
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
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公开(公告)号：US5766632A
公开(公告)日：1998-06-16
申请号：US609980
申请日：1996-02-29
申请人： Michael J. Oldham , Bruce F. Rose
发明人： Michael J. Oldham , Bruce F. Rose
CPC分类号： A61K38/17 , A61F6/08 , A61K38/168 , A61K38/1709 , Y10S424/14 , Y10S514/841 , Y10S514/843 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/953 , Y10S514/967 , Y10T428/31971
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
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