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    METHODS OF TREATING MUSCULAR DYSTROPHIES
    1.
    发明申请
    METHODS OF TREATING MUSCULAR DYSTROPHIES 审中-公开
    治疗肌肉晶状体的方法

    公开(公告)号：US20130210753A1

    公开(公告)日：2013-08-15

    申请号：US13486016

    申请日：2012-06-01

    申请人： Francesco Squadrito ,  Alessandra Bitto ,  Giuseppe Vita ,  Sonia Messina ,  Bruce P. Burnett

    发明人： Francesco Squadrito ,  Alessandra Bitto ,  Giuseppe Vita ,  Sonia Messina ,  Bruce P. Burnett

    IPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K31/352

    CPC分类号： A61K31/7048 ,  A61K31/352 ,  A61K31/353

    摘要： The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.

    摘要翻译： 本发明涉及用类黄酮治疗杜氏肌营养不良症的方法。 所述方法可以包括（a）提供包含治疗有效量的类黄酮的药物组合物，和（b）将所述组合物给予人类患者，其中所述类黄酮包含异氟烷-4-酮，其中至少一个碳位于 由醇基改性的位置8,7,6,5,2,2'，3'，4'，5'或6'。 或者，类黄酮可以包含（1）黄烷-3-醇，其中至少一个位于8,7,6,5,4,2'，3'，4'，5'或6' 被醇基改性，或者（2）游离B环黄酮，其中至少一个碳位于由醇基修饰的位置8,7,6,5或3处，并且至少一个位于 在由糖苷基团修饰的位置8,7,6,5或3处。

    Methods of Treating Muscular Dystrophies
    2.
    发明申请
    Methods of Treating Muscular Dystrophies 审中-公开
    治疗肌营养不良症的方法

    公开(公告)号：US20100190733A1

    公开(公告)日：2010-07-29

    申请号：US12693711

    申请日：2010-01-26

    申请人： Francesco Squadrito ,  Alessandra Bitto ,  Giuseppe Vita ,  Sonia Messina ,  Bruce P. Burnett

    发明人： Francesco Squadrito ,  Alessandra Bitto ,  Giuseppe Vita ,  Sonia Messina ,  Bruce P. Burnett

    IPC分类号： A61K31/352 ,  A61P21/00 ,  A61K31/7048 ,  A61K31/353

    CPC分类号： A61K31/7048 ,  A61K31/352 ,  A61K31/353

    摘要： The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2′, 3′, 4′, 5′, or 6′ modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.

    摘要翻译： 本发明涉及用类黄酮治疗杜氏肌营养不良症的方法。 所述方法可以包括（a）提供包含治疗有效量的类黄酮的药物组合物，和（b）将所述组合物给予人类患者，其中所述类黄酮包含异氟烷-4-酮，其中至少一个碳位于 由醇基改性的位置8,7,6,5,2,2'，3'，4'，5'或6'。 或者，类黄酮可以包含（1）黄烷-3-醇，其中至少一个位于8,7,6,5,4,2'，3'，4'，5'或6' 被醇基改性，或者（2）游离B环黄酮，其中至少一个碳位于由醇基修饰的位置8,7,6,5或3处，并且至少一个位于 在由糖苷基团修饰的位置8,7,6,5或3处。

    Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
    4.
    发明授权
    Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions 有权
    用于预防和治疗碳水化合物诱发的疾病和病症的制剂

    公开(公告)号：US07531521B2

    公开(公告)日：2009-05-12

    申请号：US10785704

    申请日：2004-02-24

    申请人： Bruce P. Burnett ,  Qi Jia

    发明人： Bruce P. Burnett ,  Qi Jia

    IPC分类号： A61K31/70

    CPC分类号： A61K36/906 ,  A61K31/352 ,  A61K31/366 ,  A61K36/11 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/484 ,  A61K36/486 ,  A61K36/53 ,  A61K36/539 ,  A61K36/54 ,  A61K36/60 ,  A61K36/9062 ,  A61K2300/00

    摘要： The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of diseases and conditions resulting from high carbohydrate ingestion. The method for preventing and treating these sugar-induced diseases and conditions is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了抑制由果糖和葡萄糖驱动的脂肪生成引起的糖诱导的体重增加的新方法。 用于抑制糖诱导的体重增加的方法包括施用包含游离B环类黄酮和从单一植物或多种植物合成和/或分离的黄酮的混合物，优选在植物的黄芩和相思属中分离的组合物的组合物 需要的主机。 本发明还包括用于预防和治疗由高碳水化合物摄取引起的疾病和病症的新方法。 用于预防和治疗这些糖诱发的疾病和病症的方法包括向有需要的宿主施用治疗有效量的组合物，其包含游离B环类黄酮和从单一的合成和/或分离的黄烷的混合物 植物或多种植物，优选在植物的黄芩和相思属中以及药学上可接受的载体。