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公开(公告)号:US20180263226A1
公开(公告)日:2018-09-20
申请号:US15542702
申请日:2016-01-18
申请人: Bruno DOIRON
发明人: Bruno DOIRON
IPC分类号: A01K67/027 , A61K49/00 , C12N15/113 , C07K14/82
CPC分类号: A01K67/0275 , A01K2217/056 , A01K2217/058 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , C07K14/82 , C12N15/1135 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2740/16043
摘要: Certain embodiments are directed kits comprising components for producing a mammalian cancer model. In certain aspects the components are expression vectors. In certain embodiments one or more expression vector is engineered to express a KrasG12D polypeptide, a p53 transcriptional suppressor, SMAD4 transcriptional suppressor, p16/CDKN2A transcriptional suppressor. In certain aspects the transcriptional suppressor is a short hairpin RNA (shRNA) or other nucleic acid used for RNA interference.
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公开(公告)号:US20050202559A1
公开(公告)日:2005-09-15
申请号:US10697700
申请日:2003-10-29
申请人: Scott Pownall , Anthony Cheung , Eric Hsu , Bruno Doiron
发明人: Scott Pownall , Anthony Cheung , Eric Hsu , Bruno Doiron
CPC分类号: A61K38/45 , A61K38/47 , A61K45/06 , A61K48/005 , C12N9/16 , C12N15/86 , C12N2710/10343 , C12Q1/25 , C12Q1/34 , C12Y301/03016 , G01N33/5011 , G01N33/5023
摘要: The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.
摘要翻译: 本发明提供了抑制过度增殖细胞生长或增殖或诱导过度增殖细胞退化的组合物和方法。 更具体地,本发明提供了用于刺激靶细胞(例如,过度增殖细胞)中的糖原积累的组合物和方法,以便将糖原增加至对靶细胞有毒性的水平。
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公开(公告)号:US06309878B1
公开(公告)日:2001-10-30
申请号:US08945140
申请日:1997-12-17
申请人: Ruihuan Chen , Bruno Doiron , Axel Kahn
发明人: Ruihuan Chen , Bruno Doiron , Axel Kahn
IPC分类号: C12N510
CPC分类号: C12N15/86 , A61K48/00 , C12N15/85 , C12N2740/13043 , C12N2830/00 , C12N2830/008 , C12N2830/15 , C12N2830/85
摘要: A defective recombinant virus including at least one heterologous gene controlled by a glucose-inducible expression signal, a pharmaceutical composition containing same, and cells transformed using said vector, are disclosed.
摘要翻译: 公开了包含至少一种由葡萄糖诱导型表达信号控制的异源基因的缺陷型重组病毒,含有其的药物组合物和使用所述载体转化的细胞。
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公开(公告)号:US20090041740A1
公开(公告)日:2009-02-12
申请号:US12017902
申请日:2008-01-22
申请人: SCOTT POWNALL , Anthony T. Cheung , Eric C. Hsu , Bruno Doiron
发明人: SCOTT POWNALL , Anthony T. Cheung , Eric C. Hsu , Bruno Doiron
IPC分类号: A61K38/43 , C12N5/06 , C12N15/85 , C12N15/86 , A61K38/46 , A61P35/00 , A61K38/45 , A61K31/7088 , A61K38/17
CPC分类号: A61K38/45 , A61K38/47 , A61K45/06 , A61K48/005 , C12N9/16 , C12N15/86 , C12N2710/10343 , C12Q1/25 , C12Q1/34 , C12Y301/03016 , G01N33/5011 , G01N33/5023
摘要: The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.
摘要翻译: 本发明提供了抑制过度增殖细胞生长或增殖或诱导过度增殖细胞退化的组合物和方法。 更具体地,本发明提供了用于刺激靶细胞(例如,过度增殖细胞)中的糖原积累的组合物和方法,以便将糖原增加至对靶细胞有毒性的水平。
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