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1.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06998415B2
公开(公告)日：2006-02-14
申请号：US10757606
申请日：2004-01-12
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Kathy L. Rogers, legal representative , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K31/415 , C07D23/00 , A61P29/00
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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公开(公告)号：US06512121B2
公开(公告)日：2003-01-28
申请号：US09878452
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： C07D26332
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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公开(公告)号：US06417193B1
公开(公告)日：2002-07-09
申请号：US09646074
申请日：2000-09-13
申请人： Joseph M Gruber , Bryan H Norman
发明人： Joseph M Gruber , Bryan H Norman
IPC分类号： A61K31443
CPC分类号： C07D498/04 , A61K31/4745
摘要： The present invention relates to a compound of formula (I) which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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4.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US5643933A
公开(公告)日：1997-07-01
申请号：US460324
申请日：1995-06-02
申请人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
发明人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
IPC分类号： A61P29/00 , C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12 , A61K31/44 , A61K31/42 , A61K31/425 , C07D413/06 , C07D417/02 , C09D263/32
CPC分类号： C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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公开(公告)号：US06221876B1
公开(公告)日：2001-04-24
申请号：US09646063
申请日：2000-09-13
IPC分类号： A61K3147
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which is useful for inhibiting neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及可用于抑制由MRP1部分或全部赋予抗性的肿瘤的式（I）化合物。
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6.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06696477B2
公开(公告)日：2004-02-24
申请号：US09997633
申请日：2001-11-29
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC分类号： C07D23110
CPC分类号： C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。 特别感兴趣的化合物由式I定义，其中A，Y，R 1，R 2，R 3，R 4和R 5如说明书中所定义。
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7.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06677364B2
公开(公告)日：2004-01-13
申请号：US10004960
申请日：2001-12-04
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
发明人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K314178
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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8.发明授权公开(公告)号：US06432999B1
公开(公告)日：2002-08-13
申请号：US09878538
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61K31415
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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公开(公告)号：US06369070B1
公开(公告)日：2002-04-09
申请号：US09646062
申请日：2000-09-13
申请人： Joseph M. Gruber , Julian S Kroin , Bryan H Norman
发明人： Joseph M. Gruber , Julian S Kroin , Bryan H Norman
IPC分类号： A61K314355
CPC分类号： A61K31/704 , A61K31/475 , A61K45/06 , C07D498/02 , A61K2300/00
摘要： The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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10.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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