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1.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US5643933A
公开(公告)日：1997-07-01
申请号：US460324
申请日：1995-06-02
申请人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
发明人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
IPC分类号： A61P29/00 , C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12 , A61K31/44 , A61K31/42 , A61K31/425 , C07D413/06 , C07D417/02 , C09D263/32
CPC分类号： C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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2.发明授权Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效噻吩取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06753344B2
公开(公告)日：2004-06-22
申请号：US10317751
申请日：2002-12-12
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61K3138
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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3.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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4.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06696477B2
公开(公告)日：2004-02-24
申请号：US09997633
申请日：2001-11-29
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC分类号： C07D23110
CPC分类号： C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。 特别感兴趣的化合物由式I定义，其中A，Y，R 1，R 2，R 3，R 4和R 5如说明书中所定义。
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5.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06677364B2
公开(公告)日：2004-01-13
申请号：US10004960
申请日：2001-12-04
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
发明人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K314178
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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6.发明授权
公开(公告)号：US5563165A
公开(公告)日：1996-10-08
申请号：US457059
申请日：1995-06-01
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/535
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##
摘要翻译： 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：（I）
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公开(公告)号：US5504215A
公开(公告)日：1996-04-02
申请号：US458079
申请日：1995-06-01
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
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8.发明授权
公开(公告)号：US5760068A
公开(公告)日：1998-06-02
申请号：US648113
申请日：1996-09-06
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter , Stephen H. Docter , Stella S. Yu
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter , Stephen H. Docter , Stella S. Yu
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/505 , A61K31/506 , A61P5/14 , A61P9/00 , A61P19/02 , A61P25/04 , A61P25/06 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D495/04
CPC分类号： C07D495/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## or a pharmaceutically-acceptable salt thereof.
摘要翻译： PCT No.PCT / US94 / 12720 Sec。 371日期1996年9月6日 102（e）日期1996年9月6日PCT 1994年11月14日PCT PCT。 WO95 / 15316 PCT出版物 日期：1995年6月8日描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式II定义：其中R 1，R 2，
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公开(公告)号：US5466823A
公开(公告)日：1995-11-14
申请号：US160594
申请日：1993-11-30
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , C07D413/10
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
摘要翻译： 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：其中（I）或其药学上可接受的盐。
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10.发明授权Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation 失效用于治疗炎症的取代的吡唑基苯磺酰胺化合物
公开(公告)号：US5508426A
公开(公告)日：1996-04-16
申请号：US457185
申请日：1995-06-01
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
摘要翻译： 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：其中（I）或其药学上可接受的盐。
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