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公开(公告)号：US20160289334A2
公开(公告)日：2016-10-06
申请号：US14729798
申请日：2015-06-03
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
IPC: C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US06417168B1
公开(公告)日：2002-07-09
申请号：US09111681
申请日：1998-07-08
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
IPC: A01N4304
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
Abstract translation: 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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Patent Agency Ranking
公开(公告)号：US20160083478A1
公开(公告)日：2016-03-24
申请号：US14729798
申请日：2015-06-03
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
IPC: C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US07625558B2
公开(公告)日：2009-12-01
申请号：US10100952
申请日：2002-03-19
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
IPC: A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise adminstering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US20120014965A1
公开(公告)日：2012-01-19
申请号：US13080313
申请日：2011-04-05
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
IPC: A61K38/02 , A61K31/711 , A61P35/00 , A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
Abstract translation: 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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公开(公告)号：US20090010935A1
公开(公告)日：2009-01-08
申请号：US12114475
申请日：2008-05-02
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong-Woo Park
IPC: A61K39/395 , A61K31/7088 , A61P35/00
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
Abstract translation: 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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公开(公告)号：US20150010551A1
公开(公告)日：2015-01-08
申请号：US14485525
申请日：2014-09-12
Applicant: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
Inventor： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
IPC: C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC classification number: C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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