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1.发明授权Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US09050318B2
公开(公告)日：2015-06-09
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： A61K39/395 , A61K38/37 , A61K47/48 , C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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2.发明申请公开(公告)号：US20140294821A1
公开(公告)日：2014-10-02
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells
摘要翻译： 本发明提供了施用因子VIII（加工的FVIII，单链FVIII或其组合）的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法
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公开(公告)号：US10010622B2
公开(公告)日：2018-07-03
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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4.发明申请Factor VIII-Fc Chimeric and Hybrid Polypeptides, and Methods of Use Thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US20130108629A1
公开(公告)日：2013-05-02
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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