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1.发明授权Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US09050318B2
公开(公告)日：2015-06-09
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： A61K39/395 , A61K38/37 , A61K47/48 , C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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2.发明申请公开(公告)号：US20140294821A1
公开(公告)日：2014-10-02
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells
摘要翻译： 本发明提供了施用因子VIII（加工的FVIII，单链FVIII或其组合）的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法
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3.发明申请Factor VIII-Fc Chimeric and Hybrid Polypeptides, and Methods of Use Thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US20130108629A1
公开(公告)日：2013-05-02
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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公开(公告)号：US10010622B2
公开(公告)日：2018-07-03
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：US20050260194A1
公开(公告)日：2005-11-24
申请号：US11029003
申请日：2005-01-05
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low , James Stattel
IPC分类号： A61K39/395 , C07H21/04 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/44 , C07K16/46 , C12N5/06 , C12N9/64 , C12P21/04
CPC分类号： C07K14/505 , A61K38/00 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/475 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/745 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C07K2319/73 , C12N9/6437 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20050032174A1
公开(公告)日：2005-02-10
申请号：US10841250
申请日：2004-05-06
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , James Stattel , Susan Low
IPC分类号： A61K39/395 , C07H21/04 , C07K1/02 , C07K1/06 , C07K1/10 , C07K1/107 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/745 , C07K16/00 , C07K16/44 , C07K16/46 , C12N20060101 , C12N5/06 , C12N9/64 , C12P21/00 , C12P21/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US20070172928A1
公开(公告)日：2007-07-26
申请号：US11588431
申请日：2006-10-27
申请人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
发明人： Robert Peters , Adam Mezo , Daniel Rivera , Alan Bitonti , Susan Low
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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