公开(公告)号：US20070004914A1

公开(公告)日：2007-01-04

申请号：US11519275

申请日：2006-09-11

申请人： David Johnson ,  Jory Baldridge ,  C. Sowell

发明人： David Johnson ,  Jory Baldridge ,  C. Sowell

IPC分类号： A61K31/739 ,  C08B37/00

CPC分类号： C07H15/04 ,  C07H15/26

摘要： This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine)glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present invention in the presence or absence of an antigen. In addition, methods for treating disease with the compounds of the present invention with or without an antigen are also provided in this invention.

摘要翻译： 本发明提供含有与环状氨基烷基（糖苷配基）基团糖基连接的2-脱氧-2-氨基-β-D-吡喃葡萄糖（葡糖胺）的化合物。 本发明还提供了在存在或不存在抗原的情况下使用本发明化合物诱导免疫应答的方法。 此外，本发明还提供了用或不含抗原用本发明化合物治疗疾病的方法。

公开(公告)号：US07103482B2

公开(公告)日：2006-09-05

申请号：US10710836

申请日：2004-08-05

申请人： M. Brandon Steele ,  Jeffrey Alan Hawthorne ,  Chunho Kim ,  David C. Sowell

发明人： M. Brandon Steele ,  Jeffrey Alan Hawthorne ,  Chunho Kim ,  David C. Sowell

IPC分类号： G01B5/28 ,  H01L21/00 ,  B08B6/00

CPC分类号： G01N27/002 ,  G01N2033/0095

摘要： A method and system for identifying a defect or contamination on a surface of a material. The method and system involves providing a material, such as a semiconductor wafer, using a non-vibrating contact potential difference sensor to scan the wafer, generate contact potential difference data and processing that data to identify a pattern characteristic of the defect or contamination.

摘要翻译： 用于识别材料表面上的缺陷或污染的方法和系统。 该方法和系统包括使用非振动接触电位差传感器来提供诸如半导体晶片的材料来扫描晶片，产生接触电位差数据并处理该数据以识别缺陷或污染的图案特征。

公开(公告)号：US20050107600A1

公开(公告)日：2005-05-19

申请号：US10897194

申请日：2004-07-21

申请人： David Johnson ,  Craig Johnson ,  Helene Bazin-Lee ,  C. Sowell

发明人： David Johnson ,  Craig Johnson ,  Helene Bazin-Lee ,  C. Sowell

IPC分类号： C07H5/04 ,  C12P19/04

CPC分类号： C07H5/04 ,  C07H5/02 ,  C07H11/04 ,  C07H13/04 ,  C07H15/04

摘要： This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

摘要翻译： 本发明涉及生产烷基氨基葡糖苷磷酸酯化合物的方法，以及二糖化合物的制备方法，包括各种新型中间体和中间体方法。 一方面，通过O-甲硅烷基糖苷与二卤代甲基烷基醚的反应制备糖基卤化物。

公开(公告)号：US5533107A

公开(公告)日：1996-07-02

申请号：US204677

申请日：1994-03-01

申请人： Janine M. Irwin ,  James M. Seymour ,  Iris Y. Chen ,  James M. Davis ,  David C. Sowell ,  Nailesh B. Desai ,  Julia B. Torbert

发明人： Janine M. Irwin ,  James M. Seymour ,  Iris Y. Chen ,  James M. Davis ,  David C. Sowell ,  Nailesh B. Desai ,  Julia B. Torbert

IPC分类号： H04M3/523 ,  H04Q3/66 ,  H04M3/42 ,  H04M15/00

CPC分类号： H04Q3/66 ,  H04M2207/12 ,  H04M3/5237

摘要： The present invention is a method that enables a business with multiple locations within a LATA to use a single number for its service. All callers dial the same number to reach the subscriber's business, and a network routes the calls to the most appropriate subscriber location based on the geographic location of the caller, time of day, day of week, and/or percent distribution among subscriber locations. The geographic location of the caller is determined using the calling party number (NPA-NXX-XXXX) and either mapping this number to a wire center (using the NPA-NXX) or to a block group (using the entire NPA-NXX-XXXX). An advantage of Area Number Calling is the granularity of block group routing. Block groups are defined by the Census Bureau and typically encompass a much smaller geographic area than a wire center. Block groups are defined by the Census Bureau for the entire United States. Block groups tend to encompass four to twelve blocks, and they honor natural boundaries, like rivers. This gives an ANC subscriber a greater degree of flexibility in defining which geographic areas should be routed to which subscriber locations. The present invention also provides a method of reducing the amount of geographic data that is transmitted to or stored on a database associated with the routing equipment by routing as a unit intersecting regions of multiple subscriber data tables.

摘要翻译： 本发明是一种能够在LATA内具有多个位置的业务对其服务使用单个数字的方法。 所有呼叫者拨打相同的号码以接收订户的业务，并且网络基于呼叫者的地理位置，时间，星期几和/或用户位置之间的百分比分布，将呼叫路由到最合适的用户位置。 使用主叫方号码（NPA-NXX-XXXX）确定呼叫者的地理位置，并将该号码映射到有线中心（使用NPA-NXX）或块组（使用整个NPA-NXX-XXXX ）。 区号调用的优点是块组路由的粒度。 块组由人口普查局定义，通常包含比电线中心小得多的地理区域。 统计组由美国人口普查局确定。 块组往往包含四至十二个块，它们符合自然界，如河流。 这使得ANC订户在定义哪些地理区域应被路由到哪个订户位置时具有更大的灵活性。 本发明还提供了一种通过路由作为与多个用户数据表的区域相交的单元来减少发送到或存储在与路由设备相关联的数据库上的地理数据量的方法。

公开(公告)号：USD992911S1

公开(公告)日：2023-07-25

申请号：US29845283

申请日：2022-07-06

申请人： Lei C. Sowell

设计人： Lei C. Sowell

摘要： FIG. 1 is a left side, front perspective view of a child car seat with a quick release mechanism, showing my new design;
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a right-side elevation view thereof;
FIG. 5 is a left side elevation view thereof;
FIG. 6 is a top plan view thereof;
FIG. 7 is a bottom plan view thereof; and,
FIG. 8 is a left side, front perspective view showing the child car seat with a quick release mechanism in an operative positioning in releasing the safety straps thereon.

公开(公告)号：US07308367B2

公开(公告)日：2007-12-11

申请号：US10771628

申请日：2004-02-03

申请人： M. Brandon Steele ,  Jeffrey Alan Hawthorne ,  Chunho Kim ,  David C. Sowell

发明人： M. Brandon Steele ,  Jeffrey Alan Hawthorne ,  Chunho Kim ,  David C. Sowell

IPC分类号： G01B5/28

CPC分类号： G01N27/002 ,  G01N2033/0095

摘要： A method and system for identifying a defect or contamination on a surface of a material. The method and system involves providing a material, such as a semiconductor wafer, using a non-vibrating contact potential difference sensor to scan the wafer, generate contact potential difference data and processing that data to identify a pattern characteristic of the defect or contamination.

摘要翻译： 用于识别材料表面上的缺陷或污染的方法和系统。 该方法和系统包括使用非振动接触电位差传感器来提供诸如半导体晶片的材料来扫描晶片，产生接触电位差数据并处理该数据以识别缺陷或污染的图案特征。

公开(公告)号：US20050261317A1

公开(公告)日：2005-11-24

申请号：US11110204

申请日：2005-04-20

申请人： Chanchal Sadhu ,  Ken Dick ,  Jennifer Treiberg ,  C. Sowell ,  Edward Kesicki ,  Amy Oliver

发明人： Chanchal Sadhu ,  Ken Dick ,  Jennifer Treiberg ,  C. Sowell ,  Edward Kesicki ,  Amy Oliver

IPC分类号： A61K31/517 ,  A61K31/52 ,  A61P3/10 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P25/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D403/12 ,  C07D473/00 ,  C07D473/16 ,  C07D473/24 ,  C07D473/30 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40 ,  C07D487/04

CPC分类号： A61K31/506 ,  C07D403/12 ,  C07D473/00 ,  C07D473/16 ,  C07D473/24 ,  C07D473/30 ,  C07D473/32 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40 ,  C07D487/04 ,  C12N9/1205 ,  C12N9/99 ,  C12Y207/01137

摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K5, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.

摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kdelta）活性的方法，以及治疗PI3Kdelta在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3K5的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kdelta活性的化合物，包括选择性抑制PI3Kdelta活性的化合物。 还提供了使用PI3Kdelta抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了使用PI3Kdelta抑制化合物在体外和体内抑制PI3Kdelta介导的过程的方法。