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    Adenine derivatives
    2.
    发明授权
    Adenine derivatives 有权
    腺嘌呤衍生物

    公开(公告)号：US08563717B2

    公开(公告)日：2013-10-22

    申请号：US13058465

    申请日：2009-08-07

    申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    IPC分类号： A61K31/522 ,  A61P29/02 ,  A61P37/08 ,  C07D473/16

    CPC分类号： C07D473/16 ,  A61K31/522 ,  C07D473/18

    摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; R2是具有以下结构的基团：n是具有1至6的整数; Het是含有一个氮原子的6元饱和杂环，其中Het与杂环的任何碳原子连接至 - （CH 2）n - 部分; R3是氢，C1-8烷基或C3-7环烷基C0-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

    Purine derivatives and their pharmaceutical uses
    3.
    发明授权
    Purine derivatives and their pharmaceutical uses 失效
    嘌呤衍生物及其药物用途

    公开(公告)号：US08575340B2

    公开(公告)日：2013-11-05

    申请号：US13578008

    申请日：2011-02-08

    申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  David A. Johnson ,  Charlotte Jane Mitchell

    发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  David A. Johnson ,  Charlotte Jane Mitchell

    IPC分类号： A61K31/52 ,  C07D473/18 ,  A61P31/00 ,  A61P35/00 ,  A61P37/08 ,  A61P29/00 ,  A61P37/04 ,  A61P11/06

    CPC分类号： C07D473/18 ,  C07D473/16

    摘要： The present invention relates to compounds of formula (I): wherein; R1 represents hydrogen or C1-3alkyl; n is an integer having a value of 1 to 5; X represents O or NH; Y represents C or N; or a pharmaceutically acceptable salt thereof, have been shown to be inducers of human interferon and may possess an improved profile with respect to known inducers of human interferon, for example enhanced potency. The compounds of the invention may therefore be useful in the treatment of various disorders, in particular the treatment of infectious diseases, cancer, allergic diseases and other inflammatory conditions, and their use as vaccine adjuvants.

    摘要翻译： 本发明涉及式（I）的化合物：其中： R1代表氢或C1-3烷基; n为1〜5的整数， X表示O或NH; Y表示C或N; 已经显示其是人类干扰素的诱导剂，并且相对于人干扰素的已知诱导剂可能具有改进的特征，例如增强的效力。 因此，本发明的化合物可用于治疗各种疾病，特别是治疗感染性疾病，癌症，过敏性疾病和其它炎性病症，以及它们作为疫苗佐剂的用途。

    PURINE DERIVATIVES AND THEIR PHARMACEUTICAL USES
    4.
    发明申请
    PURINE DERIVATIVES AND THEIR PHARMACEUTICAL USES 失效
    嘌呤衍生物及其药物用途

    公开(公告)号：US20120315291A1

    公开(公告)日：2012-12-13

    申请号：US13578008

    申请日：2011-02-08

    申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  David A. Johnson ,  Charlotte Jane Mitchell

    发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  David A. Johnson ,  Charlotte Jane Mitchell

    IPC分类号： A61K31/52 ,  A61P31/00 ,  A61P35/00 ,  A61P11/06 ,  A61P29/00 ,  A61K39/00 ,  A61P37/04 ,  C07D473/18 ,  A61P37/08

    CPC分类号： C07D473/18 ,  C07D473/16

    摘要： The present invention relates to compounds of formula (I): wherein; R1 represents hydrogen or C1-3alkyl; n is an integer having a value of 1 to 5; X represents O or NH; Y represents C or N; or a pharmaceutically acceptable salt thereof, have been shown to be inducers of human interferon and may possess an improved profile with respect to known inducers of human interferon, for example enhanced potency. The compounds of the invention may therefore be useful in the treatment of various disorders, in particular the treatment of infectious diseases, cancer, allergic diseases and other inflammatory conditions, and their use as vaccine adjuvants.

    摘要翻译： 本发明涉及式（I）的化合物：其中： R1代表氢或C1-3烷基; n为1〜5的整数， X表示O或NH; Y表示C或N; 已经显示其是人类干扰素的诱导剂，并且相对于人干扰素的已知诱导剂可能具有改进的特征，例如增强的效力。 因此，本发明的化合物可用于治疗各种疾病，特别是治疗感染性疾病，癌症，过敏性疾病和其它炎性病症，以及它们作为疫苗佐剂的用途。

    NOVEL ADENINE DERIVATIVES
    5.
    发明申请
    NOVEL ADENINE DERIVATIVES 有权
    新的腺嘌呤衍生物

    公开(公告)号：US20110144136A1

    公开(公告)日：2011-06-16

    申请号：US13058465

    申请日：2009-08-07

    申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    IPC分类号： A61K31/522 ,  C07D473/18 ,  C07D473/16 ,  A61P29/00 ,  A61P37/08

    CPC分类号： C07D473/16 ,  A61K31/522 ,  C07D473/18

    摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; R2是具有以下结构的基团：n是具有1至6的整数; Het是含有一个氮原子的6元饱和杂环，其中Het与杂环的任何碳原子连接至 - （CH 2）n - 部分; R3是氢，C1-8烷基或C3-7环烷基C0-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。