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公开(公告)号:US12301140B2
公开(公告)日:2025-05-13
申请号:US18137874
申请日:2023-04-21
Inventor: Matthias Preindl
Abstract: Disclosed are implementations, including a method that includes obtaining measurement samples relating to electrical operation of an electric motor drive providing power to an electric motor, deriving, based on the samples, instantaneous estimates for parameters characterizing speed and/or position of the motor according to an optimization process based on a cost function defined for the samples, and applying a filtering operation to the instantaneous estimates to generate filtered values of the motor's speed and/or position. The filtering operation includes computing the filtered values using the derived instantaneous estimates in response to a determination that a computed convexity of the cost function is greater than or equal to a convexity threshold value, and/or applying a least-squares filtering operation to the derived instantaneous estimates and using at least one set of previous estimates derived according to the optimization process applied to previous measurement samples.
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公开(公告)号:US12285464B2
公开(公告)日:2025-04-29
申请号:US16094111
申请日:2017-04-18
Applicant: The Trustees of Columbia University in the City of New York , The Brigham and Women's Hospital, Inc.
Inventor: Ira Tabas , Xiaobo Wang , Omid Farokhzad , Xiaoding Xu
IPC: C12N15/113 , A61K9/1271 , A61K9/50 , A61K31/4178 , A61K31/4439 , A61K31/7105 , A61K31/713 , A61K38/17 , A61K47/69 , A61K48/00 , A61P1/16 , G01N33/50 , G01N33/68 , A61K45/06
Abstract: The present invention relates to methods and compositions for specifically modulating the Hippo pathway transcription factor TAZ (WWTR1), as a therapeutic target for inhibiting or preventing liver conditions including the progression of steatosis-to-NASH in a patient.
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公开(公告)号:US20250127826A1
公开(公告)日:2025-04-24
申请号:US18936495
申请日:2024-11-04
Inventor: Tal DANINO , Candice GURBATRI
IPC: A61K35/741 , A61K35/00 , A61P35/00 , C07K14/535 , C07K16/28 , C12N15/70 , G01N33/53 , G01N33/574
Abstract: Orally-deliverable programmable bacteria cells that colonize colorectal tumors and produce diagnostic and therapeutic molecules, as well as related compositions and methods.
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公开(公告)号:US12280115B2
公开(公告)日:2025-04-22
申请号:US18630263
申请日:2024-04-09
Applicant: The Trustees of Columbia University in the City of New York , William Marsh Rice University
Inventor: Gerard Karsenty , Julian Berger , Han Xiao
Abstract: Cytokine-bisphosphonate conjugates and methods of use thereof in muscle functions.
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公开(公告)号:US12278722B2
公开(公告)日:2025-04-15
申请号:US18383797
申请日:2023-10-25
Inventor: Vivek Mangal , Peter R. Kinget
IPC: H04L27/06 , H03K19/0185 , H03K19/17788 , H04L27/26
Abstract: Circuit for wake-up receivers are provide. In some embodiments, the wake-up receivers include self-mixers that receive a gate bias voltage. Some of the self-mixers are single ended and some are differential. In some embodiments, the wake-up receivers include a matching network that is connected to the input of the self-mixer. In some embodiments, the wake-up receivers include a low frequency path connected to the output of the self-mixer. In some embodiments, the wake-up receivers include a high frequency path connected to the output of the self-mixer. In some embodiments, the wake-up receivers are configured to receive an encoded bit stream. In some embodiments, the wake-up receivers are configured to wake-up another receiver.
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公开(公告)号:US12265650B2
公开(公告)日:2025-04-01
申请号:US17749115
申请日:2022-05-19
Inventor: Jason Nieh , Alexander Edward Van't Hof, III
Abstract: Mechanisms for protecting an application from an untrusted operating system (OS) are provided, the methods including: determining that a virtual address for a page of memory allocated by the untrusted OS for the application belongs to a valid mapping; determining that the page of memory is not already in use; and in response to determining that the virtual address for the page of memory belongs to a valid mapping and determining that the page of memory is not already in use, mapping the page of memory to an enclaved container for the application. Some mechanisms further include unmapping the page of memory from the untrusted OS. In some mechanism, determining that the virtual address for the page of memory belongs to a valid mapping is based on a list of valid mappings for the application.
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公开(公告)号:US20250105294A1
公开(公告)日:2025-03-27
申请号:US18777255
申请日:2024-07-18
Inventor: Colin Nuckolls , Fay W. Ng , Kelsey Harrison , Qian Cheng , Wenrui Lei , Zexin Jin , Haoyu Jiang , Qifeng Jiang
IPC: H01M4/60 , H01M4/02 , H01M4/38 , H01M10/0569
Abstract: A cathode active material having a polymer with helical perylene diimide (hPDI) subunits with the side-chains of the helical perylene diimide (hPDI) subunits removed and a method of manufacturing the cathode active material are provided. A rechargeable battery cell with the polymer as a cathode material, a magnesium metal anode, and an ether-based electrolyte.
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公开(公告)号:US20250090690A1
公开(公告)日:2025-03-20
申请号:US18946509
申请日:2024-11-13
Inventor: Yi-Ting Tsai , Salvatore M. Caruso , Bruna Lopes da Costa , Stephen H. Tsang , Peter M.J. Quinn
Abstract: The present disclosure provides systems, methods, and compositions for prime-editing modification of c.828 splice site mutations in the peripherin-2 gene. Particularly the present disclosure provides systems, methods, and compositions for correcting one or more disease-causing splice site mutations selected from: c.828+3A>T, c.828+1G>A, c.828+2T>C, c.828+1G>T, and combinations thereof.
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公开(公告)号:US20250087365A1
公开(公告)日:2025-03-13
申请号:US18814823
申请日:2024-08-26
Inventor: Sarah Collins ROSSETTI , Kenrick CATO , Christopher KNAPLUND
Abstract: Disclosed are implementations, including a method for medical/clinical monitoring that includes obtaining clinical and physiological measurement data for a patient, and contextual information associated with the patient and representative of location and time at which the clinical and physiological measurement data were obtained, and obtaining clinician behavior data for the clinicians while treating the patient. The method further includes determining intermittently, using an ensemble learning process, based on the measurement data and the contextual information, one of a plurality of medical state prediction models best suited for a current clinical situation associated with the patient. The method additionally includes determining, by the determined medical state prediction model, based on the measurement data and the clinician behavior data, prediction output data representing a medical and/or clinical state trajectory for the patient, and providing notification output data representative of the medical and/or clinical state trajectory for the patient.
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公开(公告)号:US20250082752A1
公开(公告)日:2025-03-13
申请号:US18893711
申请日:2024-09-23
Inventor: Jordan Scott ORANGE , Luis Alberto PEDROZA , Michael LAM , Yu LI , Frédérique VAN DEN HAAK
IPC: A61K39/00 , C12N5/0783 , C12N9/22 , C12N15/11 , C12N15/90
Abstract: Disrupting convergence of lytic granules produced by cytotoxic lymphocytes allows non-directional degranulation, which improves and broadens killing efficiency of the cytotoxic cells in pathogenic environments such as when used for cancer therapy. Accordingly, methods of inducing multidirectional degranulation by cytotoxic effector cells in a tumor microenvironment, methods of treating a tumor, and related therapeutic composition are described.
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