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公开(公告)号：US08101186B2
公开(公告)日：2012-01-24
申请号：US11676148
申请日：2007-02-16
CPC分类号： C07K14/70539 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/70535 , G01N2333/70535
摘要： The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
摘要翻译： 本发明涉及结合人FcRn并抑制IgG的Fc部分与FcRn的结合的肽，从而调节血清IgG水平。 所公开的组合物和方法可用于例如治疗自身免疫性疾病和炎症性疾病。 本发明还涉及制备本发明的肽的方法和制备方法。
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公开(公告)号：US09012603B2
公开(公告)日：2015-04-21
申请号：US12641844
申请日：2009-12-18
IPC分类号： C07K14/705 , A61K38/00 , C07K14/74 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/735
CPC分类号： C07K14/70539 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/70535 , G01N2333/70535
摘要： The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
摘要翻译： 本发明涉及结合人FcRn并抑制IgG的Fc部分与FcRn的结合的肽，从而调节血清IgG水平。 所公开的组合物和方法可用于例如治疗自身免疫性疾病和炎症性疾病。 本发明还涉及制备本发明的肽的方法和制备方法。
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公开(公告)号：US20110059889A1
公开(公告)日：2011-03-10
申请号：US12641844
申请日：2009-12-18
IPC分类号： A61K38/12 , C07K7/64 , C07K14/00 , C07K14/79 , C07K7/52 , C07K14/76 , C07K19/00 , A61K38/16 , A61P35/00 , A61P3/10 , A61P17/06 , A61P1/04 , A61P29/00 , C07K1/22 , A61P37/06 , G01N33/53
CPC分类号： C07K14/70539 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/70535 , G01N2333/70535
摘要： The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
摘要翻译： 本发明涉及结合人FcRn并抑制IgG的Fc部分与FcRn的结合的肽，从而调节血清IgG水平。 所公开的组合物和方法可用于例如治疗自身免疫性疾病和炎症性疾病。 本发明还涉及制备本发明的肽的方法和制备方法。
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