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公开(公告)号：US20180236446A1
公开(公告)日：2018-08-23
申请号：US15898097
申请日：2018-02-15
Applicant: Cambsolv Limited
Inventor： Hugh Malkin , Nicholas James Hastings , Graham Scott Gutsell , Ian Morgan George
CPC classification number: B01L3/502715 , B01L2200/026 , B01L2200/028 , B01L2200/0605 , B01L2200/0631 , B01L2200/16 , B01L2300/049 , B01L2300/0627 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2400/049 , B01L2400/0622 , B01L2400/0644 , G01N35/0099 , G01N2035/00158 , G01N2035/0425
Abstract: Described is a modular microfluidic device (MMD) for producing an analytic composition from a biological fluid sample, said device comprising a reagent module (RM) comprising a reagent reservoir containing a reagent and an eluent reservoir containing an eluent, said reagent and eluent reservoirs being coupled to one or more RM microchannels; and a sample preparation module (SPM) comprising a SPM microchannel adapted to couple with the RM microchannel whereby fluid continuity between SPM and RM microchannels is produced on coupling, and: (i) a sample inlet for receiving said biological fluid sample; (ii) an outlet for delivering said analyte composition; (iii) a sensor component; (iv) a mixing chamber; (v) a metering chamber; (vi) an eluent chamber; (vii) a valve; and (viii) a solid phase extraction element (SPE); wherein said metering chamber is of fixed volume and shape and substantially ellipsoidal, the metering chamber having an inlet and an outlet, said inlet and/or outlet being in fluid communication with one or more microchannel(s) of the MMD.
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公开(公告)号：US20170216841A1
公开(公告)日：2017-08-03
申请号：US15427791
申请日：2017-02-08
Applicant: Cambsolv Limited
Inventor： Hugh Malkin , Nicholas James Hastings , Graham Scott Gutsell , Ian Morgan George
CPC classification number: G01N1/38 , B01L3/5027 , B01L2200/028 , B01L2200/0631 , B01L2200/146 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N1/405
Abstract: Described is a modular microfluidic device (MMD) for producing an analyte composition from a biological fluid sample, said device comprising: (a) a reagent module (RM) comprising a reagent reservoir containing a reagent and an eluent reservoir containing an eluent, said reagent and eluent reservoirs being coupled to one or more RM microchannels; and (b) a sample preparation module (SPM) comprising a SPM microchannel adapted to couple with the RM microchannel whereby fluid continuity between SPM and RM microchannels is produced on coupling, and: (i) a sample inlet for receiving said biological fluid sample; (ii) an outlet for delivering said analyte composition; (iii) a mixing chamber; (v) a metering chamber; (vi) an eluent chamber; (vii) a valve; (viii) a solid phase extraction element (SPE); and (ix) an aspirator in fluid communication with the sample inlet of the SPM for withdrawing an aliquot of said biological fluid when contained in a sample vessel, said aspirator being operably coupled to a pneumatic fluid level sensor.
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公开(公告)号：US20170348688A9
公开(公告)日：2017-12-07
申请号：US15427791
申请日：2017-02-08
Applicant: Cambsolv Limited
Inventor： Hugh Malkin , Nicholas James Hastings , Graham Scott Gutsell , Ian Morgan George
CPC classification number: G01N1/38 , B01L3/5027 , B01L2200/028 , B01L2200/0631 , B01L2200/146 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N1/405
Abstract: Described is a modular microfluidic device (MMD) for producing an analyte composition from a biological fluid sample, said device comprising: (a) a reagent module (RM) comprising a reagent reservoir containing a reagent and an eluent reservoir containing an eluent, said reagent and eluent reservoirs being coupled to one or more RM microchannels; and (b) a sample preparation module (SPM) comprising a SPM microchannel adapted to couple with the RM microchannel whereby fluid continuity between SPM and RM microchannels is produced on coupling, and: (i) a sample inlet for receiving said biological fluid sample; (ii) an outlet for delivering said analyte composition; (iii) a mixing chamber; (v) a metering chamber; (vi) an eluent chamber; (vii) a valve; (viii) a solid phase extraction element (SPE); and (ix) an aspirator in fluid communication with the sample inlet of the SPM for withdrawing an aliquot of said biological fluid when contained in a sample vessel, said aspirator being operably coupled to a pneumatic fluid level sensor.
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