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公开(公告)号：US08821958B2
公开(公告)日：2014-09-02
申请号：US13600125
申请日：2012-08-30
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。
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公开(公告)号：US20110245904A1
公开(公告)日：2011-10-06
申请号：US12752757
申请日：2010-04-01
CPC分类号： A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61F2250/0068 , B33Y80/00 , Y10T29/49826
摘要： A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.
摘要翻译： 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。
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公开(公告)号：US08562670B2
公开(公告)日：2013-10-22
申请号：US12752757
申请日：2010-04-01
CPC分类号： A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61F2250/0068 , B33Y80/00 , Y10T29/49826
摘要： A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.
摘要翻译： 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。
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公开(公告)号：US20120328769A1
公开(公告)日：2012-12-27
申请号：US13600038
申请日：2012-08-30
IPC分类号： B05D3/10
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
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公开(公告)号：US20120321778A1
公开(公告)日：2012-12-20
申请号：US13600125
申请日：2012-08-30
IPC分类号： B05D7/00
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。
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公开(公告)号：US08883244B2
公开(公告)日：2014-11-11
申请号：US13600038
申请日：2012-08-30
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。
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公开(公告)号：US08298607B2
公开(公告)日：2012-10-30
申请号：US12464602
申请日：2009-05-12
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。
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公开(公告)号：US20090285974A1
公开(公告)日：2009-11-19
申请号：US12464602
申请日：2009-05-12
IPC分类号： B05D3/00
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。
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