公开(公告)号：US6051238A

公开(公告)日：2000-04-18

申请号：US993493

申请日：1997-12-18

Applicant: David B. Volkin ,  Carl J. Burke ,  Su-Pi Sheu

Inventor： David B. Volkin ,  Carl J. Burke ,  Su-Pi Sheu

IPC: A61K20060101 ,  A61K9/00 ,  A61K9/19 ,  A61K39/13 ,  A61K39/165 ,  A61K39/20 ,  A61K39/25 ,  A61K39/29 ,  A61K47/26 ,  A61K47/42 ,  A61P31/12 ,  A61K39/12 ,  C07H3/04 ,  C12N7/04

CPC classification number: A61K39/13 ,  A61K39/0015 ,  A61K39/12 ,  A61K39/165 ,  A61K39/20 ,  A61K2039/5254 ,  A61K2039/70 ,  A61K47/26 ,  A61K47/42 ,  A61K9/19

Abstract: Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.

Abstract translation: 公开了具有增强的热稳定性的疫苗稳定剂，疫苗制剂和冻干疫苗。 疫苗制剂包含增加量的6-碳多元醇（例如山梨糖醇），增加量的二糖（例如蔗糖）和用于将pH调节至约6.0至约7.0的生理活性缓冲液的量。

公开(公告)号：US06403098B1

公开(公告)日：2002-06-11

申请号：US09366616

申请日：1999-08-03

Applicant: Carl J. Burke ,  David B. Volkin

Inventor： Carl J. Burke ,  David B. Volkin

IPC: A61K3915

CPC classification number: A61K39/15 ,  A61K39/12 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/542 ,  C12N2720/12334

Abstract: The present invention provides novel liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate for oral administration of rotavirus vaccines. The formulations also include compounds to stabilize of the vaccine compositions against loss of potency.

Abstract translation: 本发明提供了抗轮状病毒感染疫苗的新型液体和冻干制剂及其制备方法。 制剂包括适合于轮状病毒疫苗口服给药的缓冲剂。 制剂还包括稳定疫苗组合物以抵抗效力丧失的化合物。

公开(公告)号：US5932223A

公开(公告)日：1999-08-03

申请号：US938260

申请日：1997-09-26

Applicant: Carl J. Burke ,  David B. Volkin

Inventor： Carl J. Burke ,  David B. Volkin

IPC: A61K39/15 ,  A61P31/12 ,  A01N63/00

CPC classification number: A61K39/15 ,  A61K39/12 ,  A61K2039/542 ,  C12N2720/12334

Abstract: The present invention provides novel liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate for oral administration of rotavirus vaccines. The formulations also include compounds to stabilize of the vaccine compositions against loss of potency.

公开(公告)号：US06616931B1

公开(公告)日：2003-09-09

申请号：US09631807

申请日：2000-08-03

Applicant: Carl J. Burke ,  David B. Volkin

Inventor： Carl J. Burke ,  David B. Volkin

IPC: A61K3915

CPC classification number: A61K39/15 ,  A61K39/12 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/542 ,  C12N2720/12334

Abstract: The present invention provides liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate for oral administration of rotavirus vaccines. The formulations also include compounds to stabilize of the vaccine compositions against loss of potency.

Abstract translation: 本发明提供了针对轮状病毒感染的疫苗的液体和冻干制剂及其制备方法。 制剂包括适合于轮状病毒疫苗口服给药的缓冲剂。 制剂还包括稳定疫苗组合物以抵抗效力丧失的化合物。

公开(公告)号：US06290967B1

公开(公告)日：2001-09-18

申请号：US09089743

申请日：1998-06-03

Applicant: David B. Volkin ,  Su-Pi Sheu ,  Carl J. Burke

Inventor： David B. Volkin ,  Su-Pi Sheu ,  Carl J. Burke

IPC: A61K3912

CPC classification number: A61K39/165 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/0015 ,  A61K39/12 ,  A61K39/13 ,  A61K39/20 ,  A61K39/25 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/5254 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2770/36234 ,  Y02A50/466

Abstract: Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.

Abstract translation: 公开了具有增强的热稳定性的疫苗稳定剂，疫苗制剂和冻干疫苗。 疫苗制剂包含增加量的6-碳多元醇（例如山梨糖醇），增加量的二糖（例如蔗糖）和用于将pH调节至约6.0至约7.0的生理活性缓冲液的量。