公开(公告)号：US20070242755A1

公开(公告)日：2007-10-18

申请号：US11584913

申请日：2006-10-23

申请人： Carlos Ochoa

发明人： Carlos Ochoa

IPC分类号： H04B14/04

CPC分类号： H04N7/17309 ,  H04H20/76 ,  H04H20/79 ,  H04N7/106 ,  H04N7/14 ,  H04N21/2143 ,  H04N21/234318 ,  H04N21/4307 ,  H04N21/4383 ,  H04N21/6118 ,  H04N21/814 ,  H04N21/8146

摘要： The present invention relates generally to an apparatus for bi-directional communications of voice, data, and alarms, and simultaneous transmission of video signals over a single cable such as coax. In more particular, it applies to a communications system that utilizes coax-type cabling to offer computer related in-room guest services such as on-television screen display of their bills, etc. The instant invention utilizes a digital communications protocol, preferably PCM, to fit a plurality of general purpose communications channels within conventional broadcast television frequencies. These communication channels might variously be used to carry telephone voice data, thereby obviating the need for a separate phone network, or, more generally, they might be used to transport any sort of digital data (e.g., room billing information, outgoing faxes, etc.) The instant invention also provides a means for directing broadcast video information to specific rooms within the structure. Finally, the instant invention also accommodates the remote generation of signals/alarms and their detection and processing in a central facility.

摘要翻译： 本发明一般涉及用于语音，数据和报警的双向通信的装置，以及通过诸如同轴电缆的单个电缆同时传输视频信号。 更具体地，它适用于利用同轴电缆布线来提供计算机相关室内客机服务的通信系统，例如其电话屏幕显示他们的票据等。本发明利用数字通信协议，优选PCM， 以适应常规广播电视频率内的多个通用通信信道。 这些通信信道可以不同地用于携带电话语音数据，从而避免需要单独的电话网络，或者更一般地，它们可以用于传输任何类型的数字数据（例如，房间计费信息，发送传真等） 。）本发明还提供了一种用于将广播视频信息引导到结构内的特定房间的装置。 最后，本发明还适用于在中央设施中远程产生信号/报警及其检测和处理。

公开(公告)号：US5725855A

公开(公告)日：1998-03-10

申请号：US215767

申请日：1994-03-22

申请人： Augusto Carlos Ochoa ,  Mark L. Saxton ,  Dan L. Longo

发明人： Augusto Carlos Ochoa ,  Mark L. Saxton ,  Dan L. Longo

IPC分类号： C12P21/08 ,  A61K9/127 ,  A61K35/12 ,  A61K35/14 ,  A61K35/17 ,  A61K35/26 ,  A61K38/00 ,  A61K38/20 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N5/00 ,  C12N5/04 ,  C12N5/0783 ,  A61K35/28

CPC分类号： C12N5/0636 ,  A61K31/675 ,  A61K35/17 ,  A61K35/26 ,  A61K38/2013 ,  C07K16/2809 ,  C12N5/0087 ,  A61K2039/5158 ,  A61K9/127 ,  C12N2501/125 ,  C12N2501/23 ,  C12N2501/515

摘要： The present invention provides a method for enhancing the immunotherapeutic activity, e.g., antitumor activity, of immune cells by depleting immune cells of a cell subset that down-regulates the immune response, such as either CD4.sup.+ or CD8.sup.+ lymphocytes. The remaining depleted immune cell population or the separated immune cell subsets then are cultured in the presence of an antibody to a lymphocyte surface receptor, preferably an anti-CD3 monoclonal antibody (MoAb), optionally in the presence of a relatively minor amount of interleukin-2 (IL-2). These stimulated cells then are optionally additionally cultured in the presence of IL-2 without an antibody to a lymphocyte surface receptor. The present invention also provides a method of treating a mammal having tumors or immunizing a mammal against tumors by administering the stimulated depleted immune cell population or a stimulated immune cell subset to a mammal, advantageously together with an immunosuppressant, and with liposomal IL-2. The invention further provides a method of transferring the immunity of mammals that are treated or immunized in accordance with the invention by extracting splenocytes from these mammals and administering these splenocytes to a second mammal.

摘要翻译： 本发明提供了通过消耗下调免疫应答的细胞亚群（例如CD4 +或CD8 +淋巴细胞）的免疫细胞来增强免疫细胞的免疫治疗活性（例如抗肿瘤活性）的方法。 然后，在抗体对淋巴细胞表面受体（优选抗CD3单克隆抗体（MoAb））的存在下，任选地在相对少量的白细胞介素-1的存在下培养剩余的耗尽的免疫细胞群体或分离的免疫细胞亚群。 2（IL-2）。 然后任选地在IL-2存在下额外培养这些刺激的细胞，而不需要针对淋巴细胞表面受体的抗体。 本发明还提供了一种治疗具有肿瘤的哺乳动物或免疫哺乳动物免受肿瘤的方法，所述哺乳动物有利地与免疫抑制剂一起向哺乳动物施用刺激的耗竭的免疫细胞群体或刺激的免疫细胞亚群，以及与脂质体IL-2。 本发明还提供了通过从这些哺乳动物中提取脾细胞并将这些脾细胞施用于第二哺乳动物来转移根据本发明治疗或免疫的哺乳动物的免疫力的方法。

公开(公告)号：US20060011900A1

公开(公告)日：2006-01-19

申请号：US11180381

申请日：2005-07-13

申请人： Carlos Ochoa

发明人： Carlos Ochoa

IPC分类号： A01K3/00

CPC分类号： E01F15/0423 ,  E01F15/0438 ,  E01F15/143 ,  E01F15/146 ,  Y10T403/11

摘要： Consistent and reliable releasing of a guardrail during a vehicle impact is enabled by a releasable fastener for safety structures along a highway. The release of secured components such as guardrail is controlled, and precise positional cooperation is provided between securing members and the guardrail. Forces may be attenuated to further optimize response.

公开(公告)号：US4450381A

公开(公告)日：1984-05-22

申请号：US365667

申请日：1982-04-05

申请人： George B. Kendrick ,  George L. Duggan ,  Carlos Ochoa

发明人： George B. Kendrick ,  George L. Duggan ,  Carlos Ochoa

IPC分类号： H01K1/54 ,  H01K1/04

CPC分类号： H01K1/54

摘要： A tungsten-halogen incandescent lamp has a hermetically sealed light-transmitting envelope with a fill of inert gas and halogen, a tungsten filament and a preferential tungsten deposition site of palladium material within the envelope.

摘要翻译： 钨卤素白炽灯具有气密密封的透光外壳，其中填充有惰性气体和卤素，钨丝和钯材料的优先钨沉积位置。

公开(公告)号：US20080083914A1

公开(公告)日：2008-04-10

申请号：US11998577

申请日：2007-11-30

申请人： Carlos Ochoa

发明人： Carlos Ochoa

IPC分类号： A01K3/00

CPC分类号： E01F15/0423 ,  E01F15/0438 ,  E01F15/143 ,  E01F15/146

摘要： A guardrail system for installation along a highway includes a plurality of spaced elongate support posts and a guardrail mounted on the plurality of support post by securing members. The system includes one of a releasing member and an edge portion of an opening in the guardrail or the support post for releasing the guardrail from the support post in response to a selected magnitude of release load. The magnitude of the release load is in the range of ⅖ to 1⅖ times a load magnitude that yields the support post when the post is unsecured to the guardrail.

摘要翻译： 用于沿高速公路安装的护栏系统包括多个间隔开的细长支撑柱和通过固定构件安装在多个支撑柱上的护栏。 该系统包括释放构件和护栏或支撑柱中的开口的边缘部分中的一个，用于响应于所选择的释放载荷的大小从支撑柱释放护栏。 释放载荷的大小在载荷大小的2/5至12/5倍的范围内，当载荷不受护护时，产生支撑柱。

公开(公告)号：US5641677A

公开(公告)日：1997-06-24

申请号：US288428

申请日：1994-08-10

申请人： Augusto Carlos Ochoa ,  Robin Lee Geller ,  Fritz H. Bach

发明人： Augusto Carlos Ochoa ,  Robin Lee Geller ,  Fritz H. Bach

IPC分类号： A61K9/127 ,  A61K35/12 ,  A61K35/14 ,  A61K35/17 ,  A61K38/20 ,  A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  C12N5/00 ,  C12N5/02 ,  C12N5/0783 ,  C12N5/06

CPC分类号： C12N5/0087 ,  A61K35/17 ,  C07K16/2809 ,  C12N5/0636 ,  A61K2039/5158 ,  A61K9/127 ,  C12N2501/125 ,  C12N2501/23 ,  C12N2501/515

摘要： The present invention provides a method for enhancing the immunotherapeutic activity, e.g., cytotoxicity, of immune cells by depleting immune cells of a cell subset that down-regulates the immune response, such as either CD4.sup.+ or CD8.sup.+ lymphocytes. The remaining depleted immune cells are then cultured in the presence of interleukin-2 (IL-2) and an antibody to a lymphocyte surface receptor, preferably an anti-CD3 monoclonal antibody (MoAb). The present invention also provides a method of enhancing the immunotherapeutic activity, e.g., cytotoxicity, of immune cells by culturing immune cells in the presence of IL-2 and an antibody to a lymphocyte surface receptor, preferably an anti-CD3 MoAb; separating a cell subset capable of developing immunotherapeutic activity, e.g., cytotoxicity, from the cultured immune cells, e.g., either CD4.sup.+ or CD8.sup.+ lymphocytes; and then subculturing the separated lymphocytes in the presence of IL-2.

摘要翻译： 本发明提供了通过消耗下调免疫应答的细胞亚群（例如CD4 +或CD8 +淋巴细胞）的免疫细胞来增强免疫细胞的免疫治疗活性（例如细胞毒性）的方法。 然后在白细胞介素-2（IL-2）和抗淋巴细胞表面受体的抗体（优选抗CD3单克隆抗体（MoAb））的存在下培养剩余的耗尽的免疫细胞。 本发明还提供了通过在IL-2和针对淋巴细胞表面受体，优选抗CD3 MoAb的抗体的存在下培养免疫细胞来增强免疫细胞的免疫治疗活性，例如细胞毒性的方法; 从培养的免疫细胞例如CD4 +或CD8 +淋巴细胞分离能够发展免疫治疗活性（例如细胞毒性）的细胞亚群; 然后在存在IL-2的情况下传代培养分离的淋巴细胞。