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公开(公告)号:US06548651B1
公开(公告)日:2003-04-15
申请号:US09689155
申请日:2000-10-12
申请人: Peter E. Nielsen , Liam Good , Henrik Frydenlund Hansen , Frederik Beck , Leila Malik , Carsten Schou , Margit Wissenbach , Birgit Kjaeldgaard Giwercman
发明人: Peter E. Nielsen , Liam Good , Henrik Frydenlund Hansen , Frederik Beck , Leila Malik , Carsten Schou , Margit Wissenbach , Birgit Kjaeldgaard Giwercman
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , A61K47/62 , A61L2/0082 , C12N2310/152 , C12N2310/3181 , C12N2310/323 , C12N2310/3233 , C12N2310/33 , C12N2310/3513
摘要: The present invention relates to novel drugs which may be used in combating infectious micro-organisms, particularly bacteria. More specifically, the invention relates to peptide nucleic acid (PNA) sequences that are modified by conjugating cationic peptides to the PNA moiety in order to obtain novel PNA molecules that exhibit enhanced anti-infective properties.
摘要翻译: 本发明涉及可用于对抗感染性微生物,特别是细菌的新型药物。 更具体地,本发明涉及通过将阳离子肽与PNA部分缀合而修饰的肽核酸(PNA)序列,以获得表现出增强的抗感染性质的新型PNA分子。