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公开(公告)号:US11219680B2
公开(公告)日:2022-01-11
申请号:US16487621
申请日:2018-02-20
申请人: Merck Sharp & Dohme Corp. , John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Steptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Steptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US20200061179A1
公开(公告)日:2020-02-27
申请号:US16487621
申请日:2018-02-20
申请人: John E. MACNAIR , Michael A. WINTERS , Thomas SVAB , Sheng-Ching WANG , William J. SMITH , Cecilia GIOVARELLI , Merck Sharp & Dohme Corp.
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US20200054740A1
公开(公告)日:2020-02-20
申请号:US16487610
申请日:2018-02-20
IPC分类号: A61K39/385 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/36 , C07K1/107 , C07K14/315
摘要: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.
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