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公开(公告)号:US20200061179A1
公开(公告)日:2020-02-27
申请号:US16487621
申请日:2018-02-20
申请人: John E. MACNAIR , Michael A. WINTERS , Thomas SVAB , Sheng-Ching WANG , William J. SMITH , Cecilia GIOVARELLI , Merck Sharp & Dohme Corp.
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US11219680B2
公开(公告)日:2022-01-11
申请号:US16487621
申请日:2018-02-20
申请人: Merck Sharp & Dohme Corp. , John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Steptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Steptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US11090374B2
公开(公告)日:2021-08-17
申请号:US16487550
申请日:2018-02-20
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Emily Wen , Patrick McHugh , John Michael Williams , Catherine Lancaster
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116 , A61K39/00
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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4.
公开(公告)号:US20200222550A1
公开(公告)日:2020-07-16
申请号:US16482337
申请日:2018-01-30
IPC分类号: A61K47/64 , A61K39/09 , G01N33/569 , A61K47/36
摘要: The present invention provides a method of producing a polysaccharide-protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.
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公开(公告)号:US20210330777A1
公开(公告)日:2021-10-28
申请号:US17369177
申请日:2021-07-07
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Patrick McHugh
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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公开(公告)号:US20220088210A1
公开(公告)日:2022-03-24
申请号:US17544239
申请日:2021-12-07
IPC分类号: A61K47/64 , A61K39/09 , A61K47/36 , G01N33/569
摘要: The present invention provides a method of producing a polysaccharide-protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.
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公开(公告)号:US20210330778A1
公开(公告)日:2021-10-28
申请号:US17369230
申请日:2021-07-07
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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8.
公开(公告)号:US20200054733A1
公开(公告)日:2020-02-20
申请号:US16487550
申请日:2018-02-20
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Emily Wen , Patrick McHugh , John Michael Williams , Catherine Lancaster
IPC分类号: A61K39/09 , A61K39/116 , A61P31/04 , A61K47/64
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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