公开(公告)号：US11219680B2

公开(公告)日：2022-01-11

申请号：US16487621

申请日：2018-02-20

Applicant: Merck Sharp & Dohme Corp. ,  John E. MacNair ,  Michael A. Winters ,  Thomas Svab ,  Sheng-Ching Wang ,  William J. Smith ,  Cecilia Giovarelli

Inventor： John E. MacNair ,  Michael A. Winters ,  Thomas Svab ,  Sheng-Ching Wang ,  William J. Smith ,  Cecilia Giovarelli

IPC: A61K39/09 ,  A61K47/64 ,  C07K14/34 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Steptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Steptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.

公开(公告)号：US20200061179A1

公开(公告)日：2020-02-27

申请号：US16487621

申请日：2018-02-20

Applicant: John E. MACNAIR ,  Michael A. WINTERS ,  Thomas SVAB ,  Sheng-Ching WANG ,  William J. SMITH ,  Cecilia GIOVARELLI ,  Merck Sharp & Dohme Corp.

Inventor： John E. MacNair ,  Michael A. Winters ,  Thomas Svab ,  Sheng-Ching Wang ,  William J. Smith ,  Cecilia Giovarelli

IPC: A61K39/09 ,  A61K47/64 ,  C07K14/34

Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.