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公开(公告)号:US11219680B2
公开(公告)日:2022-01-11
申请号:US16487621
申请日:2018-02-20
申请人: Merck Sharp & Dohme Corp. , John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Steptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Steptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US20200061179A1
公开(公告)日:2020-02-27
申请号:US16487621
申请日:2018-02-20
申请人: John E. MACNAIR , Michael A. WINTERS , Thomas SVAB , Sheng-Ching WANG , William J. SMITH , Cecilia GIOVARELLI , Merck Sharp & Dohme Corp.
发明人: John E. MacNair , Michael A. Winters , Thomas Svab , Sheng-Ching Wang , William J. Smith , Cecilia Giovarelli
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
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公开(公告)号:US20200054740A1
公开(公告)日:2020-02-20
申请号:US16487610
申请日:2018-02-20
IPC分类号: A61K39/385 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/36 , C07K1/107 , C07K14/315
摘要: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.
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公开(公告)号:US20210177957A1
公开(公告)日:2021-06-17
申请号:US16769874
申请日:2018-12-04
申请人: William J. SMITH , Patrick MCHUGH , Michael Albert WINTERS , Julie M. SKINNER , Jian HE , Luwy MUSEY , Chitrananda ABEYGUNAWARDANA , Yadong Adam CUI , Michael J. KOSINSKI , Merck Sharp & Dohme Corp.
发明人: William J. Smith , Patrick McHugh , Michael Albert Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
摘要: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimens that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号:US20220031837A1
公开(公告)日:2022-02-03
申请号:US17412550
申请日:2021-08-26
IPC分类号: A61K39/385 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/36 , C07K1/107 , C07K14/315
摘要: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.
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公开(公告)号:US20210379174A1
公开(公告)日:2021-12-09
申请号:US17374424
申请日:2021-07-13
发明人: William J. Smith , Patrick McHugh , Michael A. Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
IPC分类号: A61K39/09 , A61K39/385 , A61K39/145 , A61P31/04 , A61K39/116 , A61K47/02 , A61K47/10 , A61K47/22
摘要: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号:US20210330777A1
公开(公告)日:2021-10-28
申请号:US17369177
申请日:2021-07-07
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Patrick McHugh
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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公开(公告)号:US11116828B2
公开(公告)日:2021-09-14
申请号:US16208778
申请日:2018-12-04
发明人: William J. Smith , Patrick McHugh , Michael Albert Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
IPC分类号: A61K39/385 , A61K39/09 , A61K39/145 , A61P31/04 , A61K9/00 , A61K39/00
摘要: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号:US11090374B2
公开(公告)日:2021-08-17
申请号:US16487550
申请日:2018-02-20
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar , Julie M. Skinner , Emily Wen , Patrick McHugh , John Michael Williams , Catherine Lancaster
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116 , A61K39/00
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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公开(公告)号:US20210330778A1
公开(公告)日:2021-10-28
申请号:US17369230
申请日:2021-07-07
发明人: Jian He , John E. MacNair , William J. Smith , Michael A. Winters , Joseph G. Joyce , Chitrananda Abeygunawardana , Luwy Musey , Hari Pujar
IPC分类号: A61K39/09 , A61K47/64 , A61P31/04 , A61K39/116
摘要: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
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