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公开(公告)号：US09056094B2
公开(公告)日：2015-06-16
申请号：US12740899
申请日：2008-10-31
申请人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
发明人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/35 , A61K47/46 , A61K2039/55516
摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine.
摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗。
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2.发明申请DETECTION/MEASUREMENT OF MALARIA INFECTION DISEASE UTILIZING NATURAL IMMUNITY BY HEMOZOIN INDUCTION, SCREENING OF PREVENTATIVE OR THERAPEUTIC MEDICINE FOR MALARIA INFECTION DISEASE, AND REGULATION OF NATURAL IMMUNITY INDUCTION 审中-公开疟原虫感染利用自然免疫的疟疾感染疾病的检测/测定，疟疾感染疾病预防或治疗药物的筛选及自然免疫诱导的调控公开(公告)号：US20120128725A1
公开(公告)日：2012-05-24
申请号：US13312260
申请日：2011-12-06
申请人： Shizuo Akira , Ken Ishii , Cevayir Coban
发明人： Shizuo Akira , Ken Ishii , Cevayir Coban
IPC分类号： A61K31/555 , C12N5/071 , A61K38/02
CPC分类号： A61K39/015 , A01K2267/0387 , A61K2039/572 , G01N33/56905 , G01N2333/445 , G01N2333/70596 , G01N2500/10 , Y02A50/58
摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.
摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。
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公开(公告)号：US20100247568A1
公开(公告)日：2010-09-30
申请号：US12740899
申请日：2008-10-31
申请人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
发明人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/35 , A61K47/46 , A61K2039/55516
摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine
摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗
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4.发明申请公开(公告)号：US20090041808A1
公开(公告)日：2009-02-12
申请号：US11792668
申请日：2005-11-04
申请人： Shizuo Akira , Ken Ishii , Cevayir Coban
发明人： Shizuo Akira , Ken Ishii , Cevayir Coban
CPC分类号： A61K39/015 , A01K2267/0387 , A61K2039/572 , G01N33/56905 , G01N2333/445 , G01N2333/70596 , G01N2500/10 , Y02A50/58
摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.
摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。
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5.发明授权公开(公告)号：US09400279B2
公开(公告)日：2016-07-26
申请号：US13312260
申请日：2011-12-06
申请人： Shizuo Akira , Ken Ishii , Cevayir Coban
发明人： Shizuo Akira , Ken Ishii , Cevayir Coban
IPC分类号： A61K31/555 , A61K38/02 , C12N5/071 , G01N33/569
CPC分类号： A61K39/015 , A01K2267/0387 , A61K2039/572 , G01N33/56905 , G01N2333/445 , G01N2333/70596 , G01N2500/10 , Y02A50/58
摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.
摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。
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公开(公告)号：US20130034731A1
公开(公告)日：2013-02-07
申请号：US13516114
申请日：2010-12-17
申请人： Shizuo Akira , Ken Ishii , Cevayir Coban , Toshihiro Tsukui , Yoshikatsu Igari , Keiichi Ohata
发明人： Shizuo Akira , Ken Ishii , Cevayir Coban , Toshihiro Tsukui , Yoshikatsu Igari , Keiichi Ohata
CPC分类号： A61K39/39 , A61K39/015 , A61K39/35 , A61K2039/543 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , Y02A50/39 , Y02A50/407 , Y02A50/466 , Y02A50/484 , Y10T428/2982
摘要： The present invention is directed to providing a method for preparing a vaccine adjuvant composition containing β-hematin and a vaccine adjuvant composition obtained by the preparation method. The present invention is directed to a vaccine adjuvant composition containing a β-hematin crystal having an average particle size of 20 to 500 nm.
摘要翻译： 本发明涉及提供一种制备含有本发明的疫苗佐剂组合物的方法和通过该制备方法获得的疫苗佐剂组合物。 本发明涉及一种含有平均粒度为20〜500nm的白蛋白晶体的疫苗佐剂组合物。
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