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    NOVEL ADJUVANT
    1.
    发明申请
    NOVEL ADJUVANT 有权
    新加坡

    公开(公告)号：US20100247568A1

    公开(公告)日：2010-09-30

    申请号：US12740899

    申请日：2008-10-31

    申请人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

    发明人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

    IPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/02 ,  A61K39/35

    CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K39/35 ,  A61K47/46 ,  A61K2039/55516

    摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine

    摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗

    Detection/Measurement Of Malaria Infection Disease Utilizing Natural Immunity By Hemozoin Induction, Screening Of Preventative Or Therapeutic Medicine For Malaria Infection Disease, And Regulation Of Natural Immunity Induction
    2.
    发明申请
    Detection/Measurement Of Malaria Infection Disease Utilizing Natural Immunity By Hemozoin Induction, Screening Of Preventative Or Therapeutic Medicine For Malaria Infection Disease, And Regulation Of Natural Immunity Induction 审中-公开
    疟疾感染疾病的检测/测量利用血液诱导的自然免疫，筛查预防或治疗疟疾感染疾病和自然免疫诱导的调节

    公开(公告)号：US20090041808A1

    公开(公告)日：2009-02-12

    申请号：US11792668

    申请日：2005-11-04

    申请人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    发明人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    IPC分类号： A61K39/00 ,  G01N33/00 ,  C12Q1/02 ,  A61P31/00 ,  A61K31/295 ,  G01N33/53

    CPC分类号： A61K39/015 ,  A01K2267/0387 ,  A61K2039/572 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2333/70596 ,  G01N2500/10 ,  Y02A50/58

    摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.

    摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。

    DETECTION/MEASUREMENT OF MALARIA INFECTION DISEASE UTILIZING NATURAL IMMUNITY BY HEMOZOIN INDUCTION, SCREENING OF PREVENTATIVE OR THERAPEUTIC MEDICINE FOR MALARIA INFECTION DISEASE, AND REGULATION OF NATURAL IMMUNITY INDUCTION
    3.
    发明申请
    DETECTION/MEASUREMENT OF MALARIA INFECTION DISEASE UTILIZING NATURAL IMMUNITY BY HEMOZOIN INDUCTION, SCREENING OF PREVENTATIVE OR THERAPEUTIC MEDICINE FOR MALARIA INFECTION DISEASE, AND REGULATION OF NATURAL IMMUNITY INDUCTION 审中-公开
    疟原虫感染利用自然免疫的疟疾感染疾病的检测/测定，疟疾感染疾病预防或治疗药物的筛选及自然免疫诱导的调控

    公开(公告)号：US20120128725A1

    公开(公告)日：2012-05-24

    申请号：US13312260

    申请日：2011-12-06

    申请人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    发明人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    IPC分类号： A61K31/555 ,  C12N5/071 ,  A61K38/02

    CPC分类号： A61K39/015 ,  A01K2267/0387 ,  A61K2039/572 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2333/70596 ,  G01N2500/10 ,  Y02A50/58

    摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.

    摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。

    Adjuvant
    4.
    发明授权
    Adjuvant 有权
    佐剂

    公开(公告)号：US09056094B2

    公开(公告)日：2015-06-16

    申请号：US12740899

    申请日：2008-10-31

    申请人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

    发明人： Toshihiro Tsukui ,  Ken Ishii ,  Shizuo Akira ,  Cevayir Coban

    IPC分类号： A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61K47/46 ,  A61K39/35

    CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K39/35 ,  A61K47/46 ,  A61K2039/55516

    摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine.

    摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗。

    Detection/measurement of malaria infection disease utilizing natural immunity by hemozoin induction, screening of preventative or therapeutic medicine for malaria infection disease, and regulation of natural immunity induction
    5.
    发明授权
    Detection/measurement of malaria infection disease utilizing natural immunity by hemozoin induction, screening of preventative or therapeutic medicine for malaria infection disease, and regulation of natural immunity induction 有权
    通过血红素诱导自然免疫的疟疾感染疾病的检测/测量，疟疾感染疾病的预防或治疗药物的筛选和天然免疫诱导的调节

    公开(公告)号：US09400279B2

    公开(公告)日：2016-07-26

    申请号：US13312260

    申请日：2011-12-06

    申请人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    发明人： Shizuo Akira ,  Ken Ishii ,  Cevayir Coban

    IPC分类号： A61K31/555 ,  A61K38/02 ,  C12N5/071 ,  G01N33/569

    CPC分类号： A61K39/015 ,  A01K2267/0387 ,  A61K2039/572 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2333/70596 ,  G01N2500/10 ,  Y02A50/58

    摘要： The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.

    摘要翻译： 本发明是提供一种利用血红素（HZ）的诱导检测和测量疟疾感染的方法; 使用检测和测量方法筛选疟疾感染疫苗的方法和用于疟疾感染的预防或治疗剂; 以及使用HZ，合成HZ或其衍生物作为佐剂或免疫刺激剂来调节诱导天然免疫的方法。 通过检测和测量HZ诱导的TLR9介导的和MyD88依赖性先天免疫活性来检测和测量疟疾感染。 疟疾感染的检测和测量可用于诊断疟疾感染。 用于检测和测量的方法也用于筛选疟疾感染的疫苗和用于疟疾感染的预防或治疗剂。 此外，HZ，合成HZ或其衍生物用作佐剂或免疫刺激剂以调节HZ诱导的先天免疫诱导。

    Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
    9.
    发明授权
    Immunostimulatory oligonucleotides and use thereof in pharmaceuticals 有权
    免疫刺激性寡核苷酸及其在药物中的应用

    公开(公告)号：US08592566B2

    公开(公告)日：2013-11-26

    申请号：US12301746

    申请日：2007-05-31

    申请人： Tomokatsu Iwamura ,  Hideki Narumi ,  Hajime Masumoto ,  Akihito Kaneda ,  Akiko Soneda ,  Shizuo Akira

    发明人： Tomokatsu Iwamura ,  Hideki Narumi ,  Hajime Masumoto ,  Akihito Kaneda ,  Akiko Soneda ,  Shizuo Akira

    IPC分类号： A61K31/711 ,  A61K31/7125 ,  A61K39/29 ,  A61K39/35

    CPC分类号： A61K31/711 ,  A61K2039/55561

    摘要： A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an application thereof are provided. That is, the present invention provides the immunostimulatory oligonucleotide composed of a base sequence represented by a formula: 5′-(G)MPXCGYQ(G)N-3′ (SEQ ID NO: 118) (X and Y are mutually independent and represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive G residues, and a length of X+Y is 6 to 20 nucleotides; XCGY contains a palindrome sequence having a length of at least 8 nucleotides and has a length of 8 to 22 nucleotides; P and Q are mutually independent and represent one nucleotide other than G; M represents an integer of 6 to 10 and N represents an integer of 0 to 3) wherein a full length thereof is 16 to 37 nucleotides (except for an oligonucleotide composed of a base sequence represented by SEQ ID NO:5), the pharmaceutical application thereof.

    摘要翻译： 提供了IFN诱导活性增强并且减少炎性细胞因子诱导活性的新型免疫刺激性寡核苷酸，并且提供了含有该诱导活性的药物及其应用。 也就是说，本发明提供了由以下通式表示的碱基序列组成的免疫刺激性寡核苷酸：5' - （G）MPXCGYQ（G）N-3'（SEQ ID NO：118）（X和Y相互独立， 长度为0〜10个核苷酸且不含4个以上连续G残基的任意序列，X + Y的长度为6〜20个核苷酸; XCGY含有长度至少为8个核苷酸的回文序列， 长度为8〜22个核苷酸; P和Q相互独立，表示除G以外的一个核苷酸; M表示6〜10的整数，N表示0〜3的整数），其全长为16〜37 核苷酸（除了由SEQ ID NO：5表示的碱基序列组成的寡核苷酸），其药学应用。

    Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide
    10.
    发明授权
    Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide 有权
    非人动物模型对支原体起始脂蛋白/脂肽无反应

    公开(公告)号：US07371921B2

    公开(公告)日：2008-05-13

    申请号：US10343388

    申请日：2001-07-31

    申请人： Shizuo Akira ,  Osamu Takeuchi

    发明人： Shizuo Akira ,  Osamu Takeuchi

    IPC分类号： A01K67/027 ,  G01N33/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/06 ,  C12N5/16 ,  C12N5/10

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0337 ,  C07K14/705 ,  G01N33/5088

    摘要： An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a response to a mycoplasma-derived lipoprotein with the use of the non-human animal model. A non-human animal model whose function of a gene that encodes a protein such as TLR6 that specifically recognizes a mycoplasma-derived lipoprotein is deficient on its chromosome, for example, a TLR6 knockout mouse, is generated. With the use of the non-human animal model unresponsive to a mycoplasma-derived lipoprotein or an immune cell such as a macrophage derived from the non-human animal model, a subject material and a mycoplasma-derived lipoprotein, a response to a mycoplasma-derived lipoprotein in the non-human animal model or the immune cell is measured/evaluated, and then an inhibitor or a promoter for a response to that is screened.

    摘要翻译： 本发明的目的是提供对支原体来源的脂蛋白/脂肽无反应的非人动物模型，以及使用非支链淀粉衍生的脂蛋白筛选抑制剂或启动子以对支原体来源的脂蛋白的应答的方法 - 人类动物模型。 产生非人动物模型，其功能是编码诸如特异性识别支原体来源的脂蛋白的TLR6等蛋白质的基因在其染色体上是缺陷的，例如TLR6敲除小鼠。 使用对支原体来源的脂蛋白或免疫细胞如源自非人动物模型的巨噬细胞无反应的非人动物模型，主题材料和支原体来源的脂蛋白，对支原体的应答， 测量/评价非人动物模型或免疫细胞中的衍生脂蛋白，然后筛选抑制剂或对其的应答的启动子。