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1.发明授权公开(公告)号：US07901881B2
公开(公告)日：2011-03-08
申请号：US11547995
申请日：2005-04-11
CPC分类号： G01N33/57407 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , C12Q1/6809 , C12Q2545/101
摘要： The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
摘要翻译： 本发明涉及在甲状腺良性病变和恶性甲状腺病变中差异表达的基因用于诊断和分期甲状腺癌的用途。
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2.发明申请公开(公告)号：US20080145841A1
公开(公告)日：2008-06-19
申请号：US11547995
申请日：2005-04-11
CPC分类号： G01N33/57407 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , C12Q1/6809 , C12Q2545/101
摘要： The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
摘要翻译： 本发明涉及在甲状腺良性病变和恶性甲状腺病变中差异表达的基因用于诊断和分期甲状腺癌的用途。
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公开(公告)号：US20110177971A1
公开(公告)日：2011-07-21
申请号：US13024845
申请日：2011-02-10
CPC分类号： G01N33/57407 , C12Q1/6837 , C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , C12Q1/6809 , C12Q2545/101
摘要： The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
摘要翻译： 本发明涉及在甲状腺良性病变和恶性甲状腺病变中差异表达的基因用于诊断和分期甲状腺癌的用途。
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公开(公告)号：US07273699B2
公开(公告)日：2007-09-25
申请号：US10206561
申请日：2002-07-25
申请人： Robert H. Lipsky , Chiara Mazzanti , David Goldman
发明人： Robert H. Lipsky , Chiara Mazzanti , David Goldman
CPC分类号： C12Q1/6827 , C12Q2527/107 , C12Q2527/113
摘要： Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.
摘要翻译： 通过检测多个核酸的融合谱之间或之间的差异来检测序列变异，例如多态性。 通过在一段时间内在温度变化期间观察核酸来产生熔融曲线。 如果将核酸稀释成用于分析的溶液，则溶液之间或之间的核酸浓度可以基本上相同。 融合谱和序列变异可用于鉴定野生型核酸序列的变化，如单核苷酸多态性（SNP），小插入或缺失或小反转。
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