FILIP1L nucleic acid fragments
    5.
    发明授权
    FILIP1L nucleic acid fragments 有权
    FILIP1L核酸片段

    公开(公告)号:US09279009B2

    公开(公告)日:2016-03-08

    申请号:US13952192

    申请日:2013-07-26

    摘要: A purified DOC1 polypeptide comprising a fragment of SEQ ID NO:1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.

    摘要翻译: 提供了包含SEQ ID NO:1的片段的纯化DOC1多肽,其中DOC1多肽不是全长DOC1多肽序列。 提供了抑制受试者血管生成的方法,包括向受试者施用编码DOC1多肽的核酸,由此受试者中的细胞产生DOC1多肽,从而抑制血管发生。 提供抑制受试者中肿瘤生长的方法,包括向受试者施用编码DOC1多肽的核酸,由此受试者中的细胞产生DOC1多肽,从而抑制肿瘤生长。

    Filipil compositions and methods for treating cancer
    8.
    发明授权
    Filipil compositions and methods for treating cancer 有权
    菲利皮组合物和治疗癌症的方法

    公开(公告)号:US08501912B2

    公开(公告)日:2013-08-06

    申请号:US12745279

    申请日:2008-12-08

    IPC分类号: A61K38/00 A61P35/00 C07K14/00

    摘要: A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.

    摘要翻译: 提供了包含SEQ ID NO:1的片段的纯化DOC1多肽,其中DOC1多肽不是全长DOC1多肽序列。 提供了抑制受试者血管生成的方法,包括向受试者施用编码DOC1多肽的核酸,由此受试者中的细胞产生DOC1多肽,从而抑制血管发生。 提供抑制受试者中肿瘤生长的方法,包括向受试者施用编码DOC1多肽的核酸,由此受试者中的细胞产生DOC1多肽,从而抑制肿瘤生长。

    Endothelial monocyte activating polypeptide II: a mediator which activates host response
    9.
    发明授权
    Endothelial monocyte activating polypeptide II: a mediator which activates host response 失效
    内皮单核细胞激活多肽II:激活宿主反应的介质

    公开(公告)号:US06734168B2

    公开(公告)日:2004-05-11

    申请号:US09851026

    申请日:2001-05-07

    IPC分类号: A61K3800

    CPC分类号: C07K16/24 A61K38/00 C07K14/52

    摘要: The present invention provides for a purified endothelial monocyte activating polypeptide II, wherein the polypeptide has an apparent molecular weight of about 20,000 Daltons. The present invention also provides for an effector cell activating protein comprising a polypeptide having an amino acid sequence wherein at least four amino acid residues are the same as RIGRTVT and are in the same relative positions. The invention also provides for a DNA which encodes the effector cell activating protein. The invention also provides for methods of inducing inflammation in a subject and methods of treating tumors in a subject. The invention also provides for a pharmaceutical composition which comprises the endothelial monocyte activating polypeptide II and a carrier.

    摘要翻译: 本发明提供纯化的内皮单核细胞活化多肽II,其中所述多肽具有约20,000道尔顿的表观分子量。 本发明还提供了一种效应细胞活化蛋白,其包含具有氨基酸序列的多肽,其中至少四个氨基酸残基与RIGRTVT相同并且处于相同的相对位置。 本发明还提供编码效应细胞活化蛋白的DNA。 本发明还提供了在受试者中诱导炎症的方法和治疗受试者肿瘤的方法。 本发明还提供了包含内皮单核细胞活化多肽II和载体的药物组合物。