公开(公告)号：US20100276359A1

公开(公告)日：2010-11-04

申请号：US12677955

申请日：2008-09-08

申请人： Masamichi Ippommatsu ,  Chie Kurusu ,  Riichi Miyamoto ,  Sayaka Ishii ,  Kazuki Nakanishi ,  Hiroyoshi Minakuchi ,  Keiko Yano

发明人： Masamichi Ippommatsu ,  Chie Kurusu ,  Riichi Miyamoto ,  Sayaka Ishii ,  Kazuki Nakanishi ,  Hiroyoshi Minakuchi ,  Keiko Yano

IPC分类号： B01D15/22

CPC分类号： A61M1/3679 ,  B01J20/103 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/28095 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3274 ,  B01J20/328 ,  B01J2220/58

摘要： Provided is an absorption column for body fluid purification by which the saturated adsorption amount of a substance to be adsorbed can be increased or the time required for reaching the saturated adsorption can be shortened, and therefore, the column capacity can be considerably reduced and the treatment time can be considerably shortened. The adsorption column having functional groups 6 specifically binding to a substance to be adsorbed including at least low density lipoprotein, immobilized on the surface of a porous support 5. The porous support 5 has double-pore structure comprising: a skeleton 7 made of a silica gel or silica glass having a three-dimensional network structure; through-pores 8 of an average diameter measured by the mercury intrusion method of 1 μm or more but less than 4 μm and having a three-dimensional network structure, which are formed in the voids of the skeleton; and micropores 9 having an average diameter measured by the mercury intrusion method larger than the grain diameter of the substance to be adsorbed, which are dispersedly formed on the surface of the skeleton.

摘要翻译： 本发明提供一种用于体液净化的吸收塔，其中吸附物质的饱和吸附量可以增加或达到饱和吸附所需的时间可以缩短，因此可以显着降低色谱柱容量和处理 时间可以大大缩短。 该吸附塔具有特定结合待吸附物质的官能团6，该物质固定在多孔载体5的表面上，至少含有低密度脂蛋白。多孔载体5具有双孔结构，包括：由二氧化硅 具有三维网络结构的凝胶或二氧化硅玻璃; 通过水银侵入法测量的平均直径为1μm以上且小于4μm的具有三维网状结构的通孔8，其形成在骨架的空隙中; 并且具有通过水银侵入法测量的平均直径的微孔9大于分散形成在骨架表面上的待吸附物质的粒径。