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公开(公告)号:US20100003681A1
公开(公告)日:2010-01-07
申请号:US12310114
申请日:2007-08-09
申请人: Junichi Azuma , Yasushi Fujio , Chieko Taniguchi , Tsuyoshi Fukuda , Makiko Maeda , Tomoko Kubota , Etsuko Tange , Risa Ueki
发明人: Junichi Azuma , Yasushi Fujio , Chieko Taniguchi , Tsuyoshi Fukuda , Makiko Maeda , Tomoko Kubota , Etsuko Tange , Risa Ueki
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6876 , C12Q2600/156 , G01N2800/307
摘要: Disclosed is a method for determination of a smoking trend in a subject which is useful for the assistance or therapy for smoking cessation, which comprises the steps of detecting one or more polymorphisms occurring on one or more genes selected from the genes (1) to (3) or a genome or in the neighborhood of the genes or the genome and determining the smoking trend based on the results of the detection: (1) nicotinic acetylcholine receptor β2 subunit (CHRNB2) gene; (2) serotonin transporter (SLC6A4(5HTT)) gene; and (3) nicotinic acetylcholine receptor α4 subunit (CHRNA4) gene.
摘要翻译: 公开了一种用于确定受试者的吸烟趋势的方法,其用于戒烟的辅助或治疗,其包括以下步骤:检测在一个或多个基因上发生的多态性,所述一个或多个基因选自基因(1)至( 3)或基因组或基因或基因组附近,并根据检测结果确定吸烟趋势:(1)烟碱乙酰胆碱受体β2亚基(CHRNB2)基因; (2)5-羟色胺转运蛋白(SLC6A4(5HTT))基因; 和(3)烟碱乙酰胆碱受体α4亚基(CHRNA4)基因。