公开(公告)号：US20120052047A1

公开(公告)日：2012-03-01

申请号：US12947829

申请日：2010-11-17

Applicant: Ying-Chen LU ,  Feng-Ching HSIEH ,  Cheng-Chih TSAI ,  Chih-Yang HUANG ,  Hsueh-Fang WANG ,  Chien-Yu TSENG

Inventor： Ying-Chen LU ,  Feng-Ching HSIEH ,  Cheng-Chih TSAI ,  Chih-Yang HUANG ,  Hsueh-Fang WANG ,  Chien-Yu TSENG

IPC: A61K35/74 ,  A61P9/00

CPC classification number: A61K35/747 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A61K2035/115 ,  C12N1/20 ,  C12R1/225 ,  A23V2200/3204 ,  A23V2200/326

Abstract: A use of probiotic strain GM-080 in treating cardiac inflammation and apoptosis is disclosed. The probiotic strain GM-080 such as Lactobacillus paracasei strain GM-080 (accession No. CCTCC M 204012) is utilized to produce a composition for treating cardiac inflammation and apoptosis in an effective dose.

Abstract translation: 公开了益生菌菌株GM-080在治疗心脏炎症和细胞凋亡中的应用。 利用益生菌菌株GM-080，例如副干酪乳杆菌菌株GM-080（登录号CCTCC M 204012）产生有效剂量治疗心脏炎症和细胞凋亡的组合物。

公开(公告)号：US09732323B2

公开(公告)日：2017-08-15

申请号：US13619893

申请日：2012-09-14

Applicant: Oscar Kuang-Sheng Lee ,  Yu-Fan Chen ,  Chien-Yu Tseng

Inventor： Oscar Kuang-Sheng Lee ,  Yu-Fan Chen ,  Chien-Yu Tseng

IPC: C12N5/071 ,  A61K35/407

CPC classification number: C12N5/067 ,  A61K35/407 ,  C12N2500/25 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/237 ,  C12N2501/39 ,  C12N2501/415 ,  C12N2506/45

Abstract: The present invention describes an efficient and rapid protocol to generate hepatocyte cells from human induced pluripotent stem cells (iPSCs). According to the method, the iPS cells can be differentiated into functional hepatocyte cells in a short time course (less than 15-20 days). The iPSC-derived hepatocyte cells of the invention have a similar gene expression profile to mature hepatocytes. Moreover, the iPSC-derived hepatocyte cells is proved to rescue lethal fulminant hepatic failure in a non-obese diabetic severe combined immunodeficient mouse model. The rapid and efficient differentiation protocol for generation of iPSC-derived hepatocyte cells may offer an alternative option for treatment of liver diseases.

公开(公告)号：US20130259836A1

公开(公告)日：2013-10-03

申请号：US13619893

申请日：2012-09-14

Applicant: Oscar Kuang-Sheng Lee ,  Yu-Fan Chen ,  Chien-Yu Tseng

Inventor： Oscar Kuang-Sheng Lee ,  Yu-Fan Chen ,  Chien-Yu Tseng

IPC: C12N5/071 ,  A61K35/407

CPC classification number: C12N5/067 ,  A61K35/407 ,  C12N2500/25 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/237 ,  C12N2501/39 ,  C12N2501/415 ,  C12N2506/45

Abstract: The present invention describes an efficient and rapid protocol to generate hepatocyte cells from human induced pluripotent stem cells (iPSCs). According to the method, the iPS cells can be differentiated into functional hepatocyte cells in a short time course (less than 15-20 days). The iPSC-derived hepatocyte cells of the invention have a similar gene expression profile to mature hepatocytes. Moreover, the iPSC-derived hepatocyte cells is proved to rescue lethal fulminant hepatic failure in a non-obese diabetic severe combined immunodeficient mouse model. The rapid and efficient differentiation protocol for generation of iPSC-derived hepatocyte cells may offer an alternative option for treatment of liver diseases.

Abstract translation: 本发明描述了从人诱导的多能干细胞（iPSC）产生肝细胞细胞的有效和快速的方案。 根据该方法，iPS细胞可在短时间内（少于15-20天）分化为功能性肝细胞。 本发明的iPSC衍生的肝细胞具有与成熟肝细胞相似的基因表达谱。 此外，iPSC来源的肝细胞被证明可以在非肥胖的糖尿病严重联合免疫缺陷小鼠模型中拯救致死性暴发性肝衰竭。 用于产生iPSC来源的肝细胞细胞的快速和有效的分化方案可提供用于治疗肝脏疾病的替代选择。