公开(公告)号：US20100129432A1

公开(公告)日：2010-05-27

申请号：US12277772

申请日：2008-11-25

Applicant: Chin-Tin Chen ,  Tsuimin Tsai ,  Hsiung-Fei Chien ,  Tse-Hsien Wang

Inventor： Chin-Tin Chen ,  Tsuimin Tsai ,  Hsiung-Fei Chien ,  Tse-Hsien Wang

IPC: A61K9/127 ,  A01N43/04 ,  A01P1/00

CPC classification number: A01N25/00 ,  A01N43/16 ,  A61K9/1075 ,  A61K9/127 ,  A61K31/136 ,  A61K31/365 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/555 ,  A61K31/722 ,  A61K41/0019 ,  A61K41/0057 ,  A61K41/0071 ,  A61K45/06 ,  A01N43/36 ,  A01N43/84 ,  A01N43/90 ,  A01N2300/00 ,  A61K2300/00

Abstract: The invention is directed to a microorganism-killing combination comprising a photosensitizer in an amount effective to kill microorganisms in a photodynamic process and a chitosan in an amount effective to enhance the microorganism-killing effect of the photosensitizer in the photodynamic process. The invention also provides the methods of administering the synergistic bacteria-killing combination to kill bacteria or treat infection.

Abstract translation: 本发明涉及一种微生物灭杀组合，其包含有效杀死光动力学过程中的微生物的量的光敏剂和一种有效提高光敏剂在光动力学过程中光敏剂的微生物杀灭作用的量的壳聚糖。 本发明还提供了施用协同杀菌组合以杀死细菌或治疗感染的方法。

公开(公告)号：US20070231375A1

公开(公告)日：2007-10-04

申请号：US11589198

申请日：2006-10-30

Applicant: Tsuimin Tsai ,  Chin-Tin Chen ,  Ruey-Long Hong ,  Hong-Da Wu

Inventor： Tsuimin Tsai ,  Chin-Tin Chen ,  Ruey-Long Hong ,  Hong-Da Wu

IPC: A61K9/127 ,  A61K31/555 ,  A61K31/409 ,  A61N5/06

CPC classification number: A61K9/1271 ,  A61K31/409 ,  A61K31/555 ,  A61K41/0071

Abstract: The present invention relates to a liposome combination, which wrapped hydrophilic drugs in water layer and wrapped hydrophobic drugs in lipid bilayer; hydrophobic drugs are photosensitizers. Using light with appropriate wavelength to activate the photosensitizer in the hydrophobic layer can result in the production of singlet oxygen and the free radical, and cause the oxidizing and breaking of the carbon chain of the phospholipid, and influences the stability of the liposome and the releases of the drug. The singlet oxygen and the free radical will attack the cancer cells at the same time as a result of combining the photodynamic- and chemo-effects.

Abstract translation: 本发明涉及脂质体组合，其在水层中包裹亲水性药物并在脂质双层中包裹疏水性药物; 疏水性药物是光敏剂。 使用具有适当波长的光激活疏水层中的光敏剂可导致单线态氧和自由基的产生，并引起磷脂的碳链的氧化和断裂，并影响脂质体的稳定性和释放 的药物。 由于结合光动力学和化学效应，单线态氧和自由基将同时侵袭癌细胞。

公开(公告)号：US20050189498A1

公开(公告)日：2005-09-01

申请号：US10639035

申请日：2003-08-12

Applicant: Adrian Wing Fai Lo ,  Hong-Shi Cao ,  Jung-Tsung Hsu ,  Ming-I Lee ,  Chin-Tin Chen ,  Chih-Wei Ho

Inventor： Adrian Wing Fai Lo ,  Hong-Shi Cao ,  Jung-Tsung Hsu ,  Ming-I Lee ,  Chin-Tin Chen ,  Chih-Wei Ho

IPC: A61N5/01 ,  A61N5/06 ,  G21G5/00 ,  G21K5/04

CPC classification number: G21K5/04

Abstract: An irradiation apparatus for a photodynamic treatment. The irradiation apparatus includes a main body, a high power light emitting element, an optical lens assembly and an optical fiber. The high power light emitting element is disposed on the main body to output light. The optical lens assembly is adjacent to the high power light emitting element and disposed on the main body to receive the light from the high power light emitting element. The optical fiber has an input end and an output end. The input end is coupled to the optical lens assembly to receive and transmit the light from the optical lens assembly.

Abstract translation: 一种用于光动力学治疗的照射装置。 照射装置包括主体，大功率发光元件，光学透镜组件和光纤。 大功率发光元件设置在主体上以输出光。 光学透镜组件与大功率发光元件相邻并且设置在主体上以接收来自高功率发光元件的光。 光纤具有输入端和输出端。 输入端耦合到光学透镜组件以接收和透射来自光学透镜组件的光。

公开(公告)号：US09649323B2

公开(公告)日：2017-05-16

申请号：US13474998

申请日：2012-05-18

Applicant: Chin-Tin Chen ,  Tsuimin Tsai

Inventor： Chin-Tin Chen ,  Tsuimin Tsai

IPC: A61K9/127 ,  A61K31/704 ,  A61K33/24 ,  A61K41/00 ,  A61K9/00

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K9/1271 ,  A61K33/24 ,  A61K41/0071

Abstract: The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.

公开(公告)号：US20120323163A1

公开(公告)日：2012-12-20

申请号：US13474998

申请日：2012-05-18

Applicant: Chin-Tin Chen ,  Tsuimin Tsai

Inventor： Chin-Tin Chen ,  Tsuimin Tsai

IPC: A61K9/127 ,  A61M37/00 ,  A61P35/00 ,  A61K31/704 ,  A61K33/24

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K9/1271 ,  A61K33/24 ,  A61K41/0071

Abstract: The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.

Abstract translation: 本发明提供了一种用于治疗受试者需要这种治疗的靶的方法，其包括（a）向受试者施用含有光敏剂和药物的脂质体，（b）在适当的时间至少一次照射靶标， 。 特别地，照射进行至少两次。

公开(公告)号：US20100310660A1

公开(公告)日：2010-12-09

申请号：US12480469

申请日：2009-06-08

Applicant: Tsuimin Tsai ,  Chin-Tin Chen ,  Jen-Chang Yang ,  Yu-Tsai Yang

Inventor： Tsuimin Tsai ,  Chin-Tin Chen ,  Jen-Chang Yang ,  Yu-Tsai Yang

IPC: A61K9/14 ,  A61K38/16 ,  A61K38/02 ,  A61K31/407 ,  A61P11/00

CPC classification number: A61K9/0075 ,  A61K9/1075 ,  A61K9/1623 ,  A61K9/1641 ,  A61K31/407

Abstract: The invention provides a dry powder microparticle for pulmonary delivery, which comprises at least one nanoparticle in the form of liposome or micelle wherein the nanopaparticle encapsulates one or more therapeutic agent therein, and a diluent layer surrounding the nanaparticles.

Abstract translation: 本发明提供了一种用于肺部递送的干粉微粒，其包含至少一种脂质体或胶束形式的纳米颗粒，其中纳米颗粒包封其中的一种或多种治疗剂，以及包围纳米颗粒的稀释剂层。